Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 282 | 788 | 2.79 | 140 | 49.65% | 91 | 32.27% | 51 | 18.09% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Toronto FC | 28 | 13 | 7 | 8 | 41 | 29 | +12 | 46 | WLWW | 12 | 7 | 3 | 2 | 20 | 9 | 16 | 6 | 4 | 6 | 21 | 20 | |
| 2 | 1 | New York Red Bulls | 29 | 12 | 8 | 9 | 49 | 37 | +12 | 44 | XWWX | 14 | 10 | 2 | 2 | 29 | 13 | 15 | 2 | 6 | 7 | 20 | 24 | |
| 3 | Philadelphia Union | 29 | 11 | 8 | 10 | 48 | 45 | +3 | 41 | XLWW | 15 | 8 | 4 | 3 | 30 | 20 | 14 | 3 | 4 | 7 | 18 | 25 | ||
| 4 | Montréal Impact | 28 | 9 | 11 | 8 | 42 | 43 | -1 | 38 | XLWX | 14 | 6 | 4 | 4 | 25 | 23 | 14 | 3 | 7 | 4 | 17 | 20 | ||
| 5 | Orlando City | 28 | 7 | 13 | 8 | 47 | 49 | -2 | 34 | LWWL | 14 | 5 | 7 | 2 | 26 | 21 | 14 | 2 | 6 | 6 | 21 | 28 | ||
| 6 | 1 | New England Revolution | 29 | 8 | 9 | 12 | 34 | 48 | -14 | 33 | WWLO | 15 | 7 | 4 | 4 | 20 | 18 | 14 | 1 | 5 | 8 | 14 | 30 | |
| 7 | 1 | D.C. United | 28 | 7 | 12 | 9 | 37 | 38 | -1 | 33 | XLWX | 14 | 6 | 4 | 4 | 25 | 16 | 14 | 1 | 8 | 5 | 12 | 22 | |
| 8 | Chicago Fire | 27 | 6 | 8 | 13 | 33 | 42 | -9 | 26 | LWLX | 14 | 5 | 6 | 3 | 20 | 16 | 13 | 1 | 2 | 10 | 13 | 26 | ||
| 9 | Columbus Crew | 27 | 5 | 11 | 11 | 36 | 45 | -9 | 26 | LLWL | 15 | 4 | 8 | 3 | 26 | 25 | 12 | 1 | 3 | 8 | 10 | 20 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | FC Dallas | 29 | 15 | 6 | 8 | 45 | 37 | +8 | 51 | LWWL | 15 | 10 | 4 | 1 | 30 | 11 | 14 | 5 | 2 | 7 | 15 | 26 | ||
| 2 | 1 | LA Galaxy | 29 | 11 | 14 | 4 | 49 | 32 | +17 | 47 | WXWO | 15 | 8 | 7 | 0 | 30 | 14 | 14 | 3 | 7 | 4 | 19 | 18 | |
| 3 | 1 | Colorado Rapids | 27 | 12 | 10 | 5 | 29 | 24 | +5 | 46 | WLLO | 13 | 9 | 4 | 0 | 16 | 5 | 14 | 3 | 6 | 5 | 13 | 19 | |
| 4 | 2 | Real Salt Lake | 29 | 12 | 8 | 9 | 42 | 41 | +1 | 44 | LXWW | 14 | 8 | 6 | 0 | 22 | 13 | 15 | 4 | 2 | 9 | 20 | 28 | |
| 5 | Sporting Kansas City | 29 | 11 | 6 | 12 | 35 | 35 | +0 | 39 | XLWX | 15 | 9 | 2 | 4 | 26 | 17 | 14 | 2 | 4 | 8 | 9 | 18 | ||
| 6 | Portland Timbers | 29 | 10 | 8 | 11 | 43 | 44 | -1 | 38 | WLWL | 15 | 10 | 2 | 3 | 32 | 20 | 14 | 0 | 6 | 8 | 11 | 24 | ||
| 7 | 2 | Vancouver Whitecaps | 29 | 9 | 7 | 13 | 37 | 45 | -8 | 34 | WLOL | 14 | 5 | 5 | 4 | 20 | 16 | 15 | 4 | 2 | 9 | 17 | 29 | |
| 8 | 1 | San Jose Earthquakes | 27 | 7 | 12 | 8 | 27 | 30 | -3 | 33 | XLOL | 14 | 6 | 6 | 2 | 15 | 9 | 13 | 1 | 6 | 6 | 12 | 21 | |
| 9 | 1 | Seattle Sounders | 27 | 9 | 5 | 13 | 33 | 37 | -4 | 32 | XLXW | 13 | 7 | 1 | 5 | 18 | 11 | 14 | 2 | 4 | 8 | 15 | 26 | |
| 10 | Houston Dynamo | 27 | 5 | 11 | 11 | 32 | 37 | -5 | 26 | XLXW | 13 | 4 | 7 | 2 | 18 | 14 | 14 | 1 | 4 | 9 | 14 | 23 | ||
| 18 | +1 | Bradley WRIGHT-PHILLIPS (New York Red Bulls) |
| 17 | David VILLA (New York City, 4p) | |
| 16 | Sebastian GIOVINCO (Toronto FC, 3p) | |
| 14 | +1 | Fanendo ADI (Portland Timbers, 1p) |
| Ignacio PIATTI (Montréal Impact, 2p) | ||
| +2 | GIOVANI dos Santos (LA Galaxy, 1p) | |
| 13 | +1 | Dominic DWYER (Sporting Kansas City) |
| Cyle LARIN (Orlando City) | ||
| 12 | +1 | Frank LAMPARD (New York City, 1p) |
| 11 | +1 | Ola KAMARA (Columbus Crew, 1p) |
| Diego VALERI (Portland Timbers, 3p) | ||
| 10 | Chris PONTIUS (Philadelphia Union) | |
| +1 | Chris WONDOLOWSKI (San Jose Earthquakes, 2p) | |
| +1 | Kevin MOLINO (Orlando City, 1p) | |
| 9 | Kei KAMARA (New England Revolution, 1p) | |
| Jordan MORRIS (Seattle Sounders) | ||
| Roland ALBERG (Philadelphia Union, 4p) | ||
| Yura MOVSISYAN (Real Salt Lake, 2p) | ||
| Didier DROGBA (Montréal Impact, 1p) | ||
| Joao PLATA (Real Salt Lake, 2p) | ||
| 8 | Clint DEMPSEY (Seattle Sounders, 2p) | |
| +1 | Robbie KEANE (LA Galaxy, 2p) | |
| Michael BARRIOS (FC Dallas) | ||
| KAKÁ (Orlando City, 4p) |
| Friday, 9 September 2016 | |||||
| Sporting Kansas City | 3-3 | Houston Dynamo | |||
| 14 | Peterson | 30 | Manotas | ||
| 26 | Espinoza | 59 | Alex Lima | ||
| 81 | Dwyer | 90 | Raúl Rodríguez | ||
| Saturday, 10 September 2016 | |||||
| FC Dallas | 0-1 | Colorado Rapids | |||
| 52 | Badji | ||||
| Columbus Crew | 1-3 | Vancouver Whitecaps | |||
| 11 | Kamara | 13(og) | Sauro | ||
| 74 | Jacobson | ||||
| 82 | Hurtado | ||||
| New England Revolution | 3-1 | New York City | |||
| 21 | Agudelo | 49 | Lampard | ||
| 42 | Nguyen | ||||
| 58 | Fagúndez | ||||
| Chicago Fire | 1-2 | Toronto FC | |||
| 58 | De Leeuw | 33 | Altidore | ||
| 52 | Osorio | ||||
| Portland Timbers | 1-0 | Real Salt Lake | |||
| 12 | Adi | ||||
| San Jose Earthquakes | 1-1 | Seattle Sounders | |||
| 20 | Wondolowski | 80 | Lodeiro | ||
| Philadelphia Union | 1-1 | Montréal Impact | |||
| 45 | Barnetta | 88 | Mancosu | ||
| Sunday, 11 September 2016 | |||||
| New York Red Bulls | 2-2 | D.C. United | |||
| 35 | Veron | 89 | Birnbaum | ||
| 54 | Wright-Phillips | 90 | Neagle | ||
| LA Galaxy | 4-2 | Orlando City | |||
| 35 | Giovani | 20 | Molino | ||
| 38 | Gordon | 90 | Shea | ||
| 45(p) | Giovani | ||||
| 70 | Keane | ||||
