Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 330 | 923 | 2.79 | 162 | 49.09% | 105 | 31.82% | 63 | 19.09% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New York Red Bulls | 33 | 15 | 9 | 9 | 59 | 44 | +15 | 54 | WWWX | 17 | 13 | 2 | 2 | 36 | 17 | 16 | 2 | 7 | 7 | 23 | 27 | ||
| 2 | Toronto FC | 33 | 13 | 11 | 9 | 48 | 37 | +11 | 50 | XLOX | 16 | 7 | 6 | 3 | 25 | 15 | 17 | 6 | 5 | 6 | 23 | 22 | ||
| 3 | D.C. United | 33 | 11 | 13 | 9 | 51 | 43 | +8 | 46 | WWWW | 17 | 9 | 4 | 4 | 35 | 18 | 16 | 2 | 9 | 5 | 16 | 25 | ||
| 4 | 1 | Montréal Impact | 33 | 11 | 12 | 10 | 49 | 50 | -1 | 45 | XWWL | 17 | 7 | 5 | 5 | 31 | 29 | 16 | 4 | 7 | 5 | 18 | 21 | |
| 5 | 1 | Philadelphia Union | 33 | 11 | 9 | 13 | 52 | 53 | -1 | 42 | LLXL | 16 | 8 | 4 | 4 | 30 | 22 | 17 | 3 | 5 | 9 | 22 | 31 | |
| 6 | New England Revolution | 33 | 10 | 9 | 14 | 41 | 54 | -13 | 39 | LWLW | 16 | 8 | 4 | 4 | 23 | 19 | 17 | 2 | 5 | 10 | 18 | 35 | ||
| 7 | 1 | Orlando City | 33 | 8 | 14 | 11 | 51 | 58 | -7 | 38 | WLOL | 16 | 5 | 7 | 4 | 27 | 26 | 17 | 3 | 7 | 7 | 24 | 32 | |
| 8 | 1 | Columbus Crew | 33 | 8 | 12 | 13 | 49 | 54 | -5 | 36 | LXWL | 17 | 6 | 8 | 3 | 31 | 25 | 16 | 2 | 4 | 10 | 18 | 29 | |
| 9 | Chicago Fire | 33 | 7 | 10 | 16 | 40 | 55 | -15 | 31 | WXLL | 17 | 6 | 8 | 3 | 26 | 21 | 16 | 1 | 2 | 13 | 14 | 34 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | FC Dallas | 33 | 17 | 8 | 8 | 50 | 40 | +10 | 59 | WWOX | 17 | 12 | 4 | 1 | 33 | 12 | 16 | 5 | 4 | 7 | 17 | 28 | ||
| 2 | Colorado Rapids | 33 | 15 | 12 | 6 | 38 | 31 | +7 | 57 | LWWW | 16 | 11 | 5 | 0 | 19 | 6 | 17 | 4 | 7 | 6 | 19 | 25 | ||
| 3 | LA Galaxy | 33 | 12 | 15 | 6 | 54 | 39 | +15 | 51 | WLLX | 16 | 8 | 7 | 1 | 32 | 18 | 17 | 4 | 8 | 5 | 22 | 21 | ||
| 4 | Real Salt Lake | 33 | 12 | 10 | 11 | 43 | 44 | -1 | 46 | OLOL | 17 | 8 | 8 | 1 | 22 | 14 | 16 | 4 | 2 | 10 | 21 | 30 | ||
| 5 | 1 | Seattle Sounders | 33 | 13 | 6 | 14 | 42 | 42 | +0 | 45 | LOWW | 16 | 9 | 2 | 5 | 20 | 11 | 17 | 4 | 4 | 9 | 22 | 31 | |
| 6 | 1 | Sporting Kansas City | 33 | 12 | 8 | 13 | 40 | 41 | -1 | 44 | OLWX | 16 | 9 | 3 | 4 | 28 | 19 | 17 | 3 | 5 | 9 | 12 | 22 | |
| 7 | Portland Timbers | 33 | 12 | 8 | 13 | 47 | 49 | -2 | 44 | WLLW | 17 | 12 | 2 | 3 | 35 | 21 | 16 | 0 | 6 | 10 | 12 | 28 | ||
| 8 | San Jose Earthquakes | 33 | 8 | 14 | 11 | 32 | 38 | -6 | 38 | OLWL | 17 | 7 | 7 | 3 | 18 | 12 | 16 | 1 | 7 | 8 | 14 | 26 | ||
| 9 | Vancouver Whitecaps | 33 | 9 | 9 | 15 | 41 | 51 | -10 | 36 | OLXL | 16 | 5 | 6 | 5 | 24 | 21 | 17 | 4 | 3 | 10 | 17 | 30 | ||
| 10 | Houston Dynamo | 33 | 7 | 12 | 14 | 38 | 44 | -6 | 33 | LOLL | 17 | 5 | 7 | 5 | 23 | 21 | 16 | 2 | 5 | 9 | 15 | 23 | ||
| 23 | +2 | Bradley WRIGHT-PHILLIPS (New York Red Bulls) |
| 22 | +1 | David VILLA (New York City, 5p) |
| 17 | +2 | Ignacio PIATTI (Montréal Impact, 3p) |
| 16 | +1 | Fanendo ADI (Portland Timbers, 2p) |
| Dominic DWYER (Sporting Kansas City) | ||
| Sebastian GIOVINCO (Toronto FC, 3p) | ||
| 15 | Ola KAMARA (Columbus Crew, 2p) | |
| 14 | Cyle LARIN (Orlando City) | |
| GIOVANI dos Santos (LA Galaxy, 1p) | ||
| 13 | Diego VALERI (Portland Timbers, 3p) | |
| 12 | Chris PONTIUS (Philadelphia Union) | |
| +1 | Chris WONDOLOWSKI (San Jose Earthquakes, 3p) | |
| Frank LAMPARD (New York City, 1p) | ||
| Jordan MORRIS (Seattle Sounders) | ||
| 11 | Kei KAMARA (New England Revolution, 1p) | |
| 10 | Robbie KEANE (LA Galaxy, 3p) | |
| Kevin MOLINO (Orlando City, 1p) | ||
| +1 | Jozy ALTIDORE (Toronto FC) | |
| Didier DROGBA (Montréal Impact, 2p) | ||
| 9 | +1 | Maximiliano URRUTI (FC Dallas) |
| Lamar NEAGLE (D.C. United, 2p) | ||
| Roland ALBERG (Philadelphia Union, 4p) | ||
| Michael BARRIOS (FC Dallas) | ||
| Yura MOVSISYAN (Real Salt Lake, 2p) | ||
| +1 | David ACCAM (Chicago Fire, 2p) | |
| Joao PLATA (Real Salt Lake, 2p) |
| Sunday, 2 October 2016 | |||||
| Vancouver Whitecaps | 1-2 | Seattle Sounders | |||
| 25(p) | Morales | 39 | Alonso | ||
| 81(p) | Evans | ||||
| Orlando City | 0-1 | Montréal Impact | |||
| 56 | Oduro | ||||
| Saturday, 8 October 2016 | |||||
| Houston Dynamo | 2-3 | Colorado Rapids | |||
| 45 | Manotas | 12 | Badji | ||
| 81 | Manotas | 54 | Badji | ||
| 79 | Gashi | ||||
| Wednesday, 12 October 2016 | |||||
| Seattle Sounders | 0-0 | Houston Dynamo | |||
| Thursday, 13 October 2016 | |||||
| Colorado Rapids | 2-1 | San Jose Earthquakes | |||
| 38 | Doyle | 57(p) | Wondolowski | ||
| 73(p) | Doyle | ||||
| Chicago Fire | 2-2 | Columbus Crew | |||
| 53(og) | Parkhurst | 13 | Jahn | ||
| 57 | De Leeuw | 80 | Jahn | ||
| Sunday, 16 October 2016 | |||||
| D.C. United | 3-1 | New York City | |||
| 27 | Mullins | 72(p) | Villa | ||
| 31 | Boswell | ||||
| 45 | Vincent | ||||
| FC Dallas | 2-1 | Seattle Sounders | |||
| 79 | Urruti | 41 | Lodeiro | ||
| 89 | Ruiz | ||||
| Houston Dynamo | 0-1 | LA Galaxy | |||
| 72 | Gordon | ||||
| New York Red Bulls | 3-2 | Columbus Crew | |||
| 53 | Grella | 73 | Jahn | ||
| 58 | Wright-Phillips | 83 | Afful | ||
| 70 | Wright-Phillips | ||||
| Chicago Fire | 2-1 | New England Revolution | |||
| 9 | De Leeuw | 43 | Fagúndez | ||
| 80 | Accam | ||||
| Montréal Impact | 2-2 | Toronto FC | |||
| 19 | Piatti | 51 | Altidore | ||
| 55(p) | Piatti | 86 | Ricketts | ||
| Portland Timbers | 1-0 | Colorado Rapids | |||
| 35(p) | Adi | ||||
| Real Salt Lake | 0-0 | Sporting Kansas City | |||
| San Jose Earthquakes | 0-0 | Vancouver Whitecaps | |||
| Philadelphia Union | 0-2 | Orlando City | |||
| 59 | Rivas | ||||
| 90 | Júlio Baptista | ||||
