| ROUND | R1 | R2 | R3 | QF | SF | F | ||||||
| l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | |
| Season archive |
| Tuesday, 13 February 2018 | ||||||
| r1l1 |  Sportivo Luqueño | 2-0 | Deportivo Cuenca | |||
| r1l1 |  Zamora | 0-2 | Colón | |||
| r1l1 |  UTC | 2-0 | Rampla Juniors | |||
| Thursday, 15 February 2018 | ||||||
| r1l1 |  Unión Española | 0-0 | Sport Huancayo | |||
| r1l1 | Defensa y Justicia | 0-1 | América | |||
| r1l1 | Nacional | 0-0 | Mineros | |||
| Tuesday, 20 February 2018 | ||||||
| r1l1 | Barcelona | 0-0 | General Díaz | |||
| r1l1 | Sport Rosario | 0-0 | Cerro | |||
| Wednesday, 21 February 2018 | ||||||
| r1l1 | Lanús | 4-2 | Sporting Cristal | |||
| Thursday, 22 February 2018 | ||||||
| r1l1 | El Nacional | 3-2 | San José | |||
| r1l1 | Everton | 1-2 | Caracas | |||
| Tuesday, 6 March 2018 | ||||||
| r1l2 | Colón | 1-0 | Zamora | 3-0 | ||
| r1l2 | Caracas | 0-1 | Everton | 2-2 | ||
| r1l2 | San José | 1-1 | El Nacional | 3-4 | ||
| Wednesday, 7 March 2018 | ||||||
| r1l2 | Sporting Cristal | 2-1 | Lanús | 4-5 | ||
| r1l2 | Deportivo Cuenca | 2-0 | Sportivo Luqueño | 2-2, p6-5 | ||
| r1l2 | Cerro | 2-0 | Sport Rosario | 2-0 | ||
| r1l2 | General Díaz | 2-1 | Barcelona | 2-1 | ||
| Thursday, 8 March 2018 | ||||||
| r1l2 | América | 0-3 | Defensa y Justicia | 1-3 | ||
| r1l2 | Rampla Juniors | 4-0 | UTC | 4-2 | ||
| r1l2 | Mineros | 0-0 | Nacional | 0-0, p3-1 | ||
| r1l2 | Sport Huancayo | 3-0 | Unión Española | 3-0 | ||
| Tuesday, 10 April 2018 | ||||||
| r1l1 | Cali | 3-0 | Danubio | |||
| r1l1 | LDU Quito | 2-1 | Guabirá | |||
| r1l1 | Jaguares | 2-1 | Boston River | |||
| Wednesday, 11 April 2018 | ||||||
| r1l1 |  Fluminense | 3-0 | Nacional Potosí | |||
| r1l1 | San Lorenzo | 1-0 | Atlético-MG | |||
| r1l1 | Blooming | 1-0 | Bahia | |||
| Thursday, 12 April 2018 | ||||||
| r1l1 | Rosario Central | 0-0 | São Paulo | |||
| r1l1 | Athlético-PR | 3-0 | Newell's Old Boys | |||
| r1l1 | Sol de América | 2-0 | Medellín | |||
| r1l1 | Audax Italiano | 1-2 | Botafogo | |||
| Wednesday, 18 April 2018 | ||||||
| r1l1 | Estudiantes | 1-1 | Temuco | |||
| Tuesday, 8 May 2018 | ||||||
| r1l2 | Atlético-MG | 0-0 | San Lorenzo | 0-1 | ||
| r1l2 | Guabirá | 3-2 | LDU Quito | 4-4 | ||
| r1l2 | Danubio | 3-2 | Cali | 3-5 | ||
| Wednesday, 9 May 2018 | ||||||
| r1l2 | São Paulo | 1-0 | Rosario Central | 1-0 | ||
| r1l2 | Botafogo | 1-1 | Audax Italiano | 3-2 | ||
| r1l2 | Temuco | 2-0 | Estudiantes | 3-1 | ||
| Thursday, 10 May 2018 | ||||||
| r1l2 | Newell's Old Boys | 2-1 | Athlético-PR | 2-4 | ||
| r1l2 | Medellín | 3-1 | Sol de América | 3-3 | ||
| r1l2 | Boston River | 3-0 | Jaguares | 4-2 | ||
| r1l2 | Nacional Potosí | 2-0 | Fluminense | 2-3 | ||
| Wednesday, 23 May 2018 | ||||||
| r1l2 | Bahia | 4-0 | Blooming | 4-1 | ||
| 3 | +3 | Emanuel HERRERA (Sporting Cristal, 2p) |
| 2 | +2 | Pablo ZEBALLOS (Sol de América) |
| +2 | Pablo ROJAS (Jaguares, 1p) | |
| +2 | Nicolás BENEDETTI (Cali) | |
| +2 | Hernán BARCOS (LDU Quito) | |
| +2 | Diego SCOTTI (Boston River) | |
| +2 | ZÉ RAFAEL (Bahia) | |
| +2 | LUÍS LEAL Anjos (Newell's Old Boys) | |
| +2 | Didier DELGADO (Cali) | |
| +2 | Carlos SAUCEDO (San José) | |
| +2 | NIKÃO (Athlético-PR) | |
| +2 | Harold REINA (Nacional Potosí, 1p) |
