Primera A| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | Apertura | 1 |
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | Finalización |
| Season archive |
| Apertura | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
 | 1 |  | Millonarios | 20 | 13 | 3 | 4 | 23 | 11 | +12 | 42 | WOWW | 10 | 8 | 1 | 1 | 11 | 4 | 10 | 5 | 2 | 3 | 12 | 7 |
| 2 | | Tolima | 20 | 12 | 4 | 4 | 29 | 14 | +15 | 40 | XOWW | 10 | 6 | 1 | 3 | 16 | 10 | 10 | 6 | 3 | 1 | 13 | 4 |
| 3 | | Nacional | 20 | 10 | 6 | 4 | 26 | 15 | +11 | 36 | LXOO | 10 | 6 | 3 | 1 | 14 | 5 | 10 | 4 | 3 | 3 | 12 | 10 |
| 4 | | Medellín | 20 | 10 | 4 | 6 | 25 | 19 | +6 | 34 | WLOW | 10 | 8 | 2 | 0 | 16 | 2 | 10 | 2 | 2 | 6 | 9 | 17 |
| 5 | | Envigado | 20 | 8 | 7 | 5 | 22 | 21 | +1 | 31 | XWLW | 10 | 6 | 3 | 1 | 12 | 6 | 10 | 2 | 4 | 4 | 10 | 15 |
| 6 | | Junior | 20 | 9 | 3 | 8 | 28 | 22 | +6 | 30 | LLWX | 10 | 8 | 1 | 1 | 22 | 9 | 10 | 1 | 2 | 7 | 6 | 13 |
| 7 | | La Equidad | 20 | 7 | 9 | 4 | 21 | 16 | +5 | 30 | WXXW | 10 | 4 | 4 | 2 | 9 | 6 | 10 | 3 | 5 | 2 | 12 | 10 |
 | 8 | | Alianza Petrolera | 20 | 7 | 8 | 5 | 22 | 20 | +2 | 29 | LWWL | 10 | 5 | 4 | 1 | 15 | 10 | 10 | 2 | 4 | 4 | 7 | 10 |
| 9 | | Bucaramanga | 20 | 8 | 5 | 7 | 25 | 25 | +0 | 29 | WXXL | 10 | 5 | 2 | 3 | 14 | 11 | 10 | 3 | 3 | 4 | 11 | 14 | |
| 10 | | Santa Fé | 20 | 7 | 6 | 7 | 29 | 26 | +3 | 27 | XXWL | 10 | 6 | 1 | 3 | 16 | 9 | 10 | 1 | 5 | 4 | 13 | 17 | |
| 11 | | Jaguares | 20 | 8 | 3 | 9 | 26 | 29 | -3 | 27 | WWLX | 10 | 7 | 1 | 2 | 17 | 9 | 10 | 1 | 2 | 7 | 9 | 20 | |
| 12 | | Once Caldas | 20 | 6 | 8 | 6 | 18 | 18 | +0 | 26 | XLLO | 10 | 4 | 4 | 2 | 12 | 8 | 10 | 2 | 4 | 4 | 6 | 10 | |
| 13 | | Rionegro | 20 | 7 | 4 | 9 | 17 | 26 | -9 | 25 | XLWW | 10 | 5 | 4 | 1 | 12 | 7 | 10 | 2 | 0 | 8 | 5 | 19 | |
| 14 | | Pereira | 20 | 6 | 5 | 9 | 21 | 26 | -5 | 23 | LXWL | 10 | 4 | 2 | 4 | 10 | 12 | 10 | 2 | 3 | 5 | 11 | 14 | |
| 15 | | América | 20 | 6 | 5 | 9 | 20 | 25 | -5 | 23 | WLLX | 10 | 5 | 3 | 2 | 15 | 10 | 10 | 1 | 2 | 7 | 5 | 15 | |
| 16 | | Deportivo Pasto | 20 | 5 | 7 | 8 | 16 | 20 | -4 | 22 | LWLO | 10 | 2 | 5 | 3 | 12 | 12 | 10 | 3 | 2 | 5 | 4 | 8 | |
| 17 | | Patriotas | 20 | 5 | 6 | 9 | 19 | 23 | -4 | 21 | WXLO | 10 | 3 | 3 | 4 | 11 | 10 | 10 | 2 | 3 | 5 | 8 | 13 | |
| 18 | | Cortuluá | 20 | 5 | 5 | 10 | 21 | 27 | -6 | 20 | XWLL | 10 | 4 | 3 | 3 | 10 | 10 | 10 | 1 | 2 | 7 | 11 | 17 | |
| 19 | | Cali | 20 | 4 | 6 | 10 | 14 | 24 | -10 | 18 | LXWL | 10 | 2 | 4 | 4 | 9 | 12 | 10 | 2 | 2 | 6 | 5 | 12 | |
| 20 | | Unión Magdalena | 20 | 2 | 6 | 12 | 9 | 24 | -15 | 12 | LXLX | 10 | 2 | 4 | 4 | 6 | 10 | 10 | 0 | 2 | 8 | 3 | 14 | |
| Cuadrangulares | ||||||
| Wednesday, 1 June 2022 | ||||||
| Group A | ||||||
| 2 | Nacional | - | Millonarios | |||
| Group B | ||||||
| 2 | Tolima | - | Medellín | |||
| Group A | ||||||
| 2 | Bucaramanga | - | Junior | |||
| Group B | ||||||
| 2 | La Equidad | - | Envigado | |||
