| ROUND | R1 | QF | SF | F | ||||
| l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | |
| Season archive |
| Tuesday, 15 February 2022 | |||||
| r1l1 |  Santos Laguna | 1-0 | CF Montréal | ||
| 88 | Ocejo | ||||
| r1l1 |  Santos | 0-2 | New York City | ||
| 5(p) | Castellanos | ||||
| 30 | Castellanos | ||||
| r1l1 |  Cavaly AS | 0-3 | New England Revolution | ||
| Score awarded as 0-3. | |||||
| Wednesday, 16 February 2022 | |||||
| r1l1 | Saprissa | 2-2 | UNAM | ||
| 45(p) | Bolaños | 28 | Corozo | ||
| 75 | Bolaños | 71 | Dinenno | ||
| r1l1 |  Guastatoya | 0-2 | León | ||
| 24 | Fernández | ||||
| 34 | Hernández | ||||
| r1l1 |  Forge | 0-1 | Cruz Azul | ||
| 30 | Otero | ||||
| Thursday, 17 February 2022 | |||||
| r1l1 |  Motagua | 0-0 | Seattle Sounders | ||
| r1l1 | Comunicaciones | 1-0 | Colorado Rapids | ||
| 89 | Espino | ||||
| 2 | +2 | Valentín CASTELLANOS (New York City, 1p) |
| +2 | Cristian BOLAÑOS (Saprissa, 1p) | |
| 1 | +1 | Karel ESPINO (Comunicaciones) |
| +1 | Omar FERNÁNDEZ (León) | |
| +1 | Juan DINENNO (UNAM) | |
| +1 | Jesús OCEJO (Santos Laguna) | |
| +1 | Rómulo OTERO (Cruz Azul) | |
| +1 | Washington COROZO (UNAM) | |
| +1 | Elías HERNÁNDEZ (León) |
