Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 193 | 455 | 2.35 | 98 | 50.78% | 48 | 24.87% | 47 | 24.35% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Columbus Crew | 25 | 13 | 5 | 7 | 33 | 27 | +6 | 44 | LLWO | 13 | 9 | 1 | 3 | 19 | 11 | 12 | 4 | 4 | 4 | 14 | 16 | ||
| 2 | New York Red Bulls | 25 | 12 | 5 | 8 | 32 | 27 | +5 | 41 | XWLW | 12 | 8 | 1 | 3 | 15 | 9 | 13 | 4 | 4 | 5 | 17 | 18 | ||
| 3 | Toronto FC | 25 | 8 | 7 | 10 | 24 | 28 | -4 | 31 | WLOL | 13 | 6 | 5 | 2 | 15 | 10 | 12 | 2 | 2 | 8 | 9 | 18 | ||
| 4 | Kansas City Wizards | 22 | 7 | 6 | 9 | 22 | 24 | -2 | 27 | XWWL | 11 | 5 | 3 | 3 | 15 | 10 | 11 | 2 | 3 | 6 | 7 | 14 | ||
| 5 | Chicago Fire | 23 | 6 | 8 | 9 | 28 | 31 | -3 | 26 | LLOX | 11 | 3 | 6 | 2 | 12 | 10 | 12 | 3 | 2 | 7 | 16 | 21 | ||
| 6 | Philadelphia Union | 24 | 6 | 6 | 12 | 27 | 39 | -12 | 24 | LWXW | 11 | 4 | 5 | 2 | 16 | 13 | 13 | 2 | 1 | 10 | 11 | 26 | ||
| 7 | New England Revolution | 24 | 7 | 3 | 14 | 24 | 41 | -17 | 24 | LLWL | 12 | 6 | 2 | 4 | 17 | 14 | 12 | 1 | 1 | 10 | 7 | 27 | ||
| 8 | D.C. United | 25 | 5 | 3 | 17 | 17 | 39 | -22 | 18 | LWLL | 12 | 3 | 1 | 8 | 9 | 17 | 13 | 2 | 2 | 9 | 8 | 22 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | LA Galaxy | 25 | 15 | 5 | 5 | 38 | 19 | +19 | 50 | WWXL | 12 | 8 | 2 | 2 | 24 | 13 | 13 | 7 | 3 | 3 | 14 | 6 | ||
| 2 | Real Salt Lake | 25 | 13 | 8 | 4 | 38 | 16 | +22 | 47 | WOWO | 13 | 10 | 3 | 0 | 28 | 6 | 12 | 3 | 5 | 4 | 10 | 10 | ||
| 3 | FC Dallas | 24 | 10 | 12 | 2 | 31 | 19 | +12 | 42 | XOWO | 12 | 7 | 4 | 1 | 18 | 9 | 12 | 3 | 8 | 1 | 13 | 10 | ||
| 4 | Colorado Rapids | 24 | 10 | 7 | 7 | 32 | 24 | +8 | 37 | WLWW | 12 | 7 | 4 | 1 | 20 | 7 | 12 | 3 | 3 | 6 | 12 | 17 | ||
| 5 | San Jose Earthquakes | 23 | 10 | 6 | 7 | 25 | 23 | +2 | 36 | WOWL | 12 | 6 | 3 | 3 | 14 | 10 | 11 | 4 | 3 | 4 | 11 | 13 | ||
| 6 | Seattle Sounders | 25 | 10 | 6 | 9 | 30 | 29 | +1 | 36 | WOLW | 13 | 6 | 3 | 4 | 16 | 13 | 12 | 4 | 3 | 5 | 14 | 16 | ||
| 7 | Chivas USA | 23 | 7 | 4 | 12 | 25 | 29 | -4 | 25 | WLWL | 11 | 5 | 2 | 4 | 14 | 11 | 12 | 2 | 2 | 8 | 11 | 18 | ||
| 8 | Houston Dynamo | 24 | 6 | 5 | 13 | 29 | 40 | -11 | 23 | LLLW | 13 | 5 | 3 | 5 | 22 | 18 | 11 | 1 | 2 | 8 | 7 | 22 | ||
| 14 | Edson BUDDLE (LA Galaxy) | |
| 12 | Juan Pablo ÁNGEL (New York Red Bulls, 2p) | |
| 11 | +2 | Dwayne DE ROSARIO (Toronto FC, 2p) |
| Sébastien LE TOUX (Philadelphia Union, 2p) | ||
| 10 | +1 | Omar CUMMINGS (Colorado Rapids) |
| Fredy MONTERO (Seattle Sounders) | ||
| +1 | Conor CASEY (Colorado Rapids, 3p) | |
| 9 | +1 | Álvaro SABORIO (Real Salt Lake, 1p) |
| +1 | Chris WONDOLOWSKI (San Jose Earthquakes, 1p) | |
| Justin BRAUN (Chivas USA) | ||
| 8 | Kei KAMARA (Kansas City Wizards) | |
| Steve ZAKUANI (Seattle Sounders) | ||
| Jeff CUNNINGHAM (FC Dallas, 2p) | ||
| 7 | +2 | Landon DONOVAN (LA Galaxy, 3p) |
| Danny MWANGA (Philadelphia Union) | ||
| Guillermo BARROS SCHELOTTO (Columbus Crew, 3p) | ||
| +1 | Brian CHING (Houston Dynamo) | |
| Marco PAPPA (Chicago Fire) | ||
| 6 | Marko PEROVIĆ (New England Revolution) | |
| Edgar ESPÍNDOLA (Real Salt Lake) | ||
| Chad BARRETT (Toronto FC) | ||
| David FERREIRA (FC Dallas, 3p) | ||
| Javier MORALES (Real Salt Lake) |
| Wednesday, 15 September 2010 | |||||
| San Jose Earthquakes | 1-0 | Philadelphia Union | |||
| 69 | Wondolowski | ||||
| Thursday, 16 September 2010 | |||||
| FC Dallas | 2-2 | New York Red Bulls | |||
| 24 | Rodríguez | 45 | Ballouchy | ||
| 68 | Alexander | 82(og) | Benítez | ||
| Saturday, 18 September 2010 | |||||
| Houston Dynamo | 1-2 | Toronto FC | |||
| 18 | Ching | 60 | De Rosario | ||
| 90 | De Rosario | ||||
| Colorado Rapids | 3-0 | New England Revolution | |||
| 5 | Cummings | ||||
| 35 | Casey | ||||
| 83 | Thompson | ||||
| Columbus Crew | 0-4 | Seattle Sounders | |||
| 4 | Nkufo | ||||
| 39 | Nkufo | ||||
| 42(p) | Sturgis | ||||
| 75 | Nkufo | ||||
| LA Galaxy | 2-1 | D.C. United | |||
| 81 | Donovan | 60 | Najar | ||
| 86 | Donovan | ||||
| Real Salt Lake | 1-0 | Chicago Fire | |||
| 45(p) | Saborio | ||||
