Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 204 | 493 | 2.41 | 100 | 49.02% | 51 | 25.00% | 53 | 25.98% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Columbus Crew | 26 | 13 | 6 | 7 | 35 | 29 | +6 | 45 | XLLW | 13 | 9 | 1 | 3 | 19 | 11 | 13 | 4 | 5 | 4 | 16 | 18 | ||
| 2 | New York Red Bulls | 26 | 13 | 5 | 8 | 34 | 27 | +7 | 44 | WXWL | 12 | 8 | 1 | 3 | 15 | 9 | 14 | 5 | 4 | 5 | 19 | 18 | ||
| 3 | 1 | Kansas City Wizards | 25 | 9 | 6 | 10 | 29 | 30 | -1 | 33 | LWWX | 13 | 6 | 3 | 4 | 20 | 16 | 12 | 3 | 3 | 6 | 9 | 14 | |
| 4 | 1 | Toronto FC | 26 | 8 | 7 | 11 | 26 | 31 | -5 | 31 | LWLO | 14 | 6 | 5 | 3 | 17 | 13 | 12 | 2 | 2 | 8 | 9 | 18 | |
| 5 | 1 | Philadelphia Union | 25 | 7 | 6 | 12 | 30 | 39 | -9 | 27 | WLWX | 12 | 5 | 5 | 2 | 19 | 13 | 13 | 2 | 1 | 10 | 11 | 26 | |
| 6 | 1 | Chicago Fire | 24 | 6 | 8 | 10 | 28 | 32 | -4 | 26 | LLLO | 12 | 3 | 6 | 3 | 12 | 11 | 12 | 3 | 2 | 7 | 16 | 21 | |
| 7 | New England Revolution | 26 | 7 | 5 | 14 | 28 | 45 | -17 | 26 | XXLL | 13 | 6 | 3 | 4 | 19 | 16 | 13 | 1 | 2 | 10 | 9 | 29 | ||
| 8 | D.C. United | 26 | 5 | 3 | 18 | 18 | 42 | -24 | 18 | LLWL | 13 | 3 | 1 | 9 | 10 | 20 | 13 | 2 | 2 | 9 | 8 | 22 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | LA Galaxy | 26 | 15 | 5 | 6 | 38 | 21 | +17 | 50 | LWWX | 13 | 8 | 2 | 3 | 24 | 15 | 13 | 7 | 3 | 3 | 14 | 6 | ||
| 2 | Real Salt Lake | 26 | 13 | 9 | 4 | 39 | 17 | +22 | 48 | XWOW | 14 | 10 | 4 | 0 | 29 | 7 | 12 | 3 | 5 | 4 | 10 | 10 | ||
| 3 | FC Dallas | 26 | 11 | 13 | 2 | 36 | 22 | +14 | 46 | WXXO | 13 | 7 | 5 | 1 | 20 | 11 | 13 | 4 | 8 | 1 | 16 | 11 | ||
| 4 | 1 | San Jose Earthquakes | 24 | 11 | 6 | 7 | 28 | 25 | +3 | 39 | WWOW | 12 | 6 | 3 | 3 | 14 | 10 | 12 | 5 | 3 | 4 | 14 | 15 | |
| 5 | 1 | Seattle Sounders | 26 | 11 | 6 | 9 | 31 | 29 | +2 | 39 | WWOL | 13 | 6 | 3 | 4 | 16 | 13 | 13 | 5 | 3 | 5 | 15 | 16 | |
| 6 | 2 | Colorado Rapids | 25 | 10 | 8 | 7 | 33 | 25 | +8 | 38 | XWLW | 12 | 7 | 4 | 1 | 20 | 7 | 13 | 3 | 4 | 6 | 13 | 18 | |
| 7 | 1 | Houston Dynamo | 26 | 7 | 5 | 14 | 35 | 45 | -10 | 26 | WLLL | 13 | 5 | 3 | 5 | 22 | 18 | 13 | 2 | 2 | 9 | 13 | 27 | |
| 8 | 1 | Chivas USA | 25 | 7 | 4 | 14 | 25 | 34 | -9 | 25 | LLWL | 12 | 5 | 2 | 5 | 14 | 13 | 13 | 2 | 2 | 9 | 11 | 21 | |
| 14 | Edson BUDDLE (LA Galaxy) | |
| 13 | +1 | Juan Pablo ÁNGEL (New York Red Bulls, 3p) |
| 12 | +3 | Chris WONDOLOWSKI (San Jose Earthquakes, 2p) |
| +1 | Dwayne DE ROSARIO (Toronto FC, 2p) | |
| +1 | Sébastien LE TOUX (Philadelphia Union, 2p) | |
| 11 | +1 | Conor CASEY (Colorado Rapids, 3p) |
| 10 | +2 | Kei KAMARA (Kansas City Wizards) |
| Omar CUMMINGS (Colorado Rapids) | ||
| Fredy MONTERO (Seattle Sounders) | ||
| +2 | Jeff CUNNINGHAM (FC Dallas, 2p) | |
| 9 | Álvaro SABORIO (Real Salt Lake, 1p) | |
| Justin BRAUN (Chivas USA) | ||
| 8 | +1 | Guillermo BARROS SCHELOTTO (Columbus Crew, 4p) |
| Steve ZAKUANI (Seattle Sounders) | ||
| 7 | Landon DONOVAN (LA Galaxy, 3p) | |
| Danny MWANGA (Philadelphia Union) | ||
| +1 | David FERREIRA (FC Dallas, 4p) | |
| Brian CHING (Houston Dynamo) | ||
| Marco PAPPA (Chicago Fire) | ||
| 6 | Marko PEROVIĆ (New England Revolution) | |
| Edgar ESPÍNDOLA (Real Salt Lake) | ||
| Chad BARRETT (Toronto FC) | ||
| Javier MORALES (Real Salt Lake) |
| Sunday, 19 September 2010 | |||||
| Chivas USA | 0-2 | Kansas City Wizards | |||
| 70 | Kamara | ||||
| 83 | Bunbury | ||||
| Wednesday, 22 September 2010 | |||||
| FC Dallas | 2-2 | New England Revolution | |||
| 80(p) | Ferreira | 5 | Joseph | ||
| 90 | Cunningham | 66 | Stolica | ||
| Kansas City Wizards | 4-3 | Houston Dynamo | |||
| 35 | Kamara | 13 | Weaver | ||
| 60 | Bunbury | 34 | Oduro | ||
| 72(og) | Serioux | 37 | Serioux | ||
| 90 | Wolff | ||||
| Friday, 24 September 2010 | |||||
| LA Galaxy | 0-2 | New York Red Bulls | |||
| 36 | Richards | ||||
| 60(p) | Ángel | ||||
| Saturday, 25 September 2010 | |||||
| D.C. United | 1-3 | Houston Dynamo | |||
| 29 | Najar | 66(og) | McTavish | ||
| 70 | Cameron | ||||
| 90 | Oduro | ||||
| New England Revolution | 2-2 | Columbus Crew | |||
| 2 | Phelan | 62(og) | Gibbs | ||
| 56 | Joseph | 80(p) | Barros Schelotto | ||
| Kansas City Wizards | 1-3 | FC Dallas | |||
| 57 | Smith | 4 | Chávez | ||
| 12 | Rodríguez | ||||
| 82 | Cunningham | ||||
| Chicago Fire | 0-1 | Seattle Sounders | |||
| 88 | Nkufo | ||||
| Real Salt Lake | 1-1 | Colorado Rapids | |||
| 90 | Borchers | 36 | Casey | ||
| Toronto FC | 2-3 | San Jose Earthquakes | |||
| 66 | De Rosario | 3(p) | Wondolowski | ||
| 79 | Maicon Carioca | 53 | Wondolowski | ||
| 67 | Wondolowski | ||||
| Philadelphia Union | 3-0 | Chivas USA | |||
| 25 | Moreno | ||||
| 45 | Okugo | ||||
| 69 | Le Toux | ||||
