Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 213 | 516 | 2.42 | 104 | 48.83% | 53 | 24.88% | 56 | 26.29% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | New York Red Bulls | 27 | 14 | 5 | 8 | 35 | 27 | +8 | 47 | WWXW | 13 | 9 | 1 | 3 | 16 | 9 | 14 | 5 | 4 | 5 | 19 | 18 | |
| 2 | 1 | Columbus Crew | 27 | 13 | 7 | 7 | 35 | 29 | +6 | 46 | OXLL | 14 | 9 | 2 | 3 | 19 | 11 | 13 | 4 | 5 | 4 | 16 | 18 | |
| 3 | Kansas City Wizards | 26 | 9 | 6 | 11 | 29 | 31 | -2 | 33 | LLWW | 13 | 6 | 3 | 4 | 20 | 16 | 13 | 3 | 3 | 7 | 9 | 15 | ||
| 4 | Toronto FC | 27 | 8 | 7 | 12 | 28 | 34 | -6 | 31 | LLWL | 14 | 6 | 5 | 3 | 17 | 13 | 13 | 2 | 2 | 9 | 11 | 21 | ||
| 5 | 1 | Chicago Fire | 26 | 7 | 8 | 11 | 31 | 35 | -4 | 29 | LWLL | 12 | 3 | 6 | 3 | 12 | 11 | 14 | 4 | 2 | 8 | 19 | 24 | |
| 6 | 1 | Philadelphia Union | 27 | 7 | 7 | 13 | 32 | 44 | -12 | 28 | XLWL | 13 | 5 | 6 | 2 | 20 | 14 | 14 | 2 | 1 | 11 | 12 | 30 | |
| 7 | New England Revolution | 27 | 7 | 5 | 15 | 29 | 47 | -18 | 26 | LXXL | 14 | 6 | 3 | 5 | 20 | 18 | 13 | 1 | 2 | 10 | 9 | 29 | ||
| 8 | D.C. United | 27 | 6 | 3 | 18 | 19 | 42 | -23 | 21 | WLLW | 13 | 3 | 1 | 9 | 10 | 20 | 14 | 3 | 2 | 9 | 9 | 22 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Real Salt Lake | 27 | 14 | 9 | 4 | 41 | 18 | +23 | 51 | WXWO | 14 | 10 | 4 | 0 | 29 | 7 | 13 | 4 | 5 | 4 | 12 | 11 | |
| 2 | 1 | LA Galaxy | 26 | 15 | 5 | 6 | 38 | 21 | +17 | 50 | LWWX | 13 | 8 | 2 | 3 | 24 | 15 | 13 | 7 | 3 | 3 | 14 | 6 | |
| 3 | FC Dallas | 27 | 12 | 13 | 2 | 39 | 22 | +17 | 49 | WWXX | 14 | 8 | 5 | 1 | 23 | 11 | 13 | 4 | 8 | 1 | 16 | 11 | ||
| 4 | 1 | Seattle Sounders | 27 | 12 | 6 | 9 | 34 | 31 | +3 | 42 | WWWO | 14 | 7 | 3 | 4 | 19 | 15 | 13 | 5 | 3 | 5 | 15 | 16 | |
| 5 | 1 | Colorado Rapids | 27 | 11 | 8 | 8 | 37 | 27 | +10 | 41 | LWXW | 14 | 8 | 4 | 2 | 24 | 9 | 13 | 3 | 4 | 6 | 13 | 18 | |
| 6 | 2 | San Jose Earthquakes | 26 | 11 | 7 | 8 | 28 | 28 | +0 | 40 | OLWW | 13 | 6 | 3 | 4 | 14 | 13 | 13 | 5 | 4 | 4 | 14 | 15 | |
| 7 | Houston Dynamo | 27 | 7 | 6 | 14 | 36 | 46 | -10 | 27 | XWLL | 13 | 5 | 3 | 5 | 22 | 18 | 14 | 2 | 3 | 9 | 14 | 28 | ||
| 8 | Chivas USA | 25 | 7 | 4 | 14 | 25 | 34 | -9 | 25 | LLWL | 12 | 5 | 2 | 5 | 14 | 13 | 13 | 2 | 2 | 9 | 11 | 21 | ||
| 14 | Edson BUDDLE (LA Galaxy) | |
| 13 | +1 | Dwayne DE ROSARIO (Toronto FC, 2p) |
| +1 | Sébastien LE TOUX (Philadelphia Union, 2p) | |
| Juan Pablo ÁNGEL (New York Red Bulls, 3p) | ||
| 12 | Chris WONDOLOWSKI (San Jose Earthquakes, 2p) | |
| +2 | Omar CUMMINGS (Colorado Rapids) | |
| 11 | +1 | Jeff CUNNINGHAM (FC Dallas, 3p) |
| Conor CASEY (Colorado Rapids, 3p) | ||
| 10 | Kei KAMARA (Kansas City Wizards) | |
| +1 | Álvaro SABORIO (Real Salt Lake, 1p) | |
| Fredy MONTERO (Seattle Sounders) | ||
| 9 | Justin BRAUN (Chivas USA) | |
| +1 | Steve ZAKUANI (Seattle Sounders) | |
| 8 | Guillermo BARROS SCHELOTTO (Columbus Crew, 4p) | |
| 7 | Landon DONOVAN (LA Galaxy, 3p) | |
| Danny MWANGA (Philadelphia Union) | ||
| +1 | Chad BARRETT (Toronto FC) | |
| David FERREIRA (FC Dallas, 4p) | ||
| Brian CHING (Houston Dynamo) | ||
| Marco PAPPA (Chicago Fire) | ||
| 6 | Marko PEROVIĆ (New England Revolution) | |
| Edgar ESPÍNDOLA (Real Salt Lake) | ||
| Javier MORALES (Real Salt Lake) |
| Wednesday, 29 September 2010 | |||||
| Colorado Rapids | 4-1 | Philadelphia Union | |||
| 8 | Cummings | 90 | McInerney | ||
| 15 | Cummings | ||||
| 68 | Thompson | ||||
| 86 | Amarikwa | ||||
| San Jose Earthquakes | 0-3 | Chicago Fire | |||
| 39 | Kinney | ||||
| 72 | Ljungberg | ||||
| 90 | Nyarko | ||||
| Saturday, 2 October 2010 | |||||
| FC Dallas | 3-0 | Chicago Fire | |||
| 19 | Rodríguez | ||||
| 46 | Chávez | ||||
| 67(p) | Cunningham | ||||
| Colorado Rapids | 0-1 | D.C. United | |||
| 45 | Allsopp | ||||
| New York Red Bulls | 1-0 | Kansas City Wizards | |||
| 6 | Richards | ||||
| Columbus Crew | 0-0 | San Jose Earthquakes | |||
| New England Revolution | 1-2 | Real Salt Lake | |||
| 82 | Mansally | 68 | Borchers | ||
| 84 | Saborio | ||||
| Seattle Sounders | 3-2 | Toronto FC | |||
| 21 | Zakuani | 16 | De Rosario | ||
| 26 | Nkufo | 88 | Barrett | ||
| 59 | Nyassi | ||||
| Philadelphia Union | 1-1 | Houston Dynamo | |||
| 40 | Le Toux | 12 | Hainault | ||
