Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 292 | 820 | 2.80 | 142 | 48.63% | 96 | 32.88% | 54 | 18.49% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Toronto FC | 29 | 13 | 8 | 8 | 44 | 32 | +12 | 47 | XWLW | 13 | 7 | 4 | 2 | 23 | 12 | 16 | 6 | 4 | 6 | 21 | 20 | ||
| 2 | New York Red Bulls | 30 | 12 | 9 | 9 | 52 | 40 | +12 | 45 | XXWW | 14 | 10 | 2 | 2 | 29 | 13 | 16 | 2 | 7 | 7 | 23 | 27 | ||
| 3 | Philadelphia Union | 30 | 11 | 8 | 11 | 49 | 47 | +2 | 41 | LXLW | 15 | 8 | 4 | 3 | 30 | 20 | 15 | 3 | 4 | 8 | 19 | 27 | ||
| 4 | Montréal Impact | 29 | 9 | 11 | 9 | 43 | 46 | -3 | 38 | LXLW | 15 | 6 | 4 | 5 | 26 | 26 | 14 | 3 | 7 | 4 | 17 | 20 | ||
| 5 | 1 | New England Revolution | 30 | 9 | 9 | 12 | 37 | 49 | -12 | 36 | WWWL | 15 | 7 | 4 | 4 | 20 | 18 | 15 | 2 | 5 | 8 | 17 | 31 | |
| 6 | 1 | D.C. United | 29 | 7 | 13 | 9 | 39 | 40 | -1 | 34 | XXLW | 14 | 6 | 4 | 4 | 25 | 16 | 15 | 1 | 9 | 5 | 14 | 24 | |
| 7 | 2 | Orlando City | 29 | 7 | 13 | 9 | 48 | 53 | -5 | 34 | LLWW | 15 | 5 | 7 | 3 | 27 | 25 | 14 | 2 | 6 | 6 | 21 | 28 | |
| 8 | 1 | Columbus Crew | 28 | 6 | 11 | 11 | 40 | 46 | -6 | 29 | WLLW | 15 | 4 | 8 | 3 | 26 | 25 | 13 | 2 | 3 | 8 | 14 | 21 | |
| 9 | 1 | Chicago Fire | 28 | 6 | 9 | 13 | 35 | 44 | -9 | 27 | XLWL | 15 | 5 | 7 | 3 | 22 | 18 | 13 | 1 | 2 | 10 | 13 | 26 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | FC Dallas | 30 | 15 | 7 | 8 | 47 | 39 | +8 | 52 | XLWW | 15 | 10 | 4 | 1 | 30 | 11 | 15 | 5 | 3 | 7 | 17 | 28 | ||
| 2 | LA Galaxy | 30 | 11 | 15 | 4 | 51 | 34 | +17 | 48 | XWXW | 15 | 8 | 7 | 0 | 30 | 14 | 15 | 3 | 8 | 4 | 21 | 20 | ||
| 3 | Colorado Rapids | 28 | 12 | 11 | 5 | 29 | 24 | +5 | 47 | OWLL | 14 | 9 | 5 | 0 | 16 | 5 | 14 | 3 | 6 | 5 | 13 | 19 | ||
| 4 | Real Salt Lake | 30 | 12 | 8 | 10 | 42 | 42 | +0 | 44 | LLXW | 15 | 8 | 6 | 1 | 22 | 14 | 15 | 4 | 2 | 9 | 20 | 28 | ||
| 5 | 1 | Portland Timbers | 30 | 11 | 8 | 11 | 45 | 45 | +0 | 41 | WWLW | 16 | 11 | 2 | 3 | 34 | 21 | 14 | 0 | 6 | 8 | 11 | 24 | |
| 6 | 1 | Sporting Kansas City | 30 | 11 | 7 | 12 | 37 | 37 | +0 | 40 | XXLW | 16 | 9 | 3 | 4 | 28 | 19 | 14 | 2 | 4 | 8 | 9 | 18 | |
| 7 | 2 | Seattle Sounders | 28 | 10 | 5 | 13 | 34 | 37 | -3 | 35 | WXLX | 14 | 8 | 1 | 5 | 19 | 11 | 14 | 2 | 4 | 8 | 15 | 26 | |
| 8 | 1 | Vancouver Whitecaps | 30 | 9 | 7 | 14 | 37 | 46 | -9 | 34 | LWLO | 14 | 5 | 5 | 4 | 20 | 16 | 16 | 4 | 2 | 10 | 17 | 30 | |
| 9 | 1 | San Jose Earthquakes | 28 | 7 | 13 | 8 | 27 | 30 | -3 | 34 | OXLO | 14 | 6 | 6 | 2 | 15 | 9 | 14 | 1 | 7 | 6 | 12 | 21 | |
| 10 | Houston Dynamo | 28 | 6 | 11 | 11 | 33 | 37 | -4 | 29 | WXLX | 13 | 4 | 7 | 2 | 18 | 14 | 15 | 2 | 4 | 9 | 15 | 23 | ||
| 20 | +2 | Bradley WRIGHT-PHILLIPS (New York Red Bulls) |
| 17 | David VILLA (New York City, 4p) | |
| 16 | Sebastian GIOVINCO (Toronto FC, 3p) | |
| 15 | +1 | Fanendo ADI (Portland Timbers, 1p) |
| 14 | +1 | Dominic DWYER (Sporting Kansas City) |
| Ignacio PIATTI (Montréal Impact, 2p) | ||
| +1 | Cyle LARIN (Orlando City) | |
| GIOVANI dos Santos (LA Galaxy, 1p) | ||
| 13 | +2 | Ola KAMARA (Columbus Crew, 1p) |
| 12 | Frank LAMPARD (New York City, 1p) | |
| +1 | Diego VALERI (Portland Timbers, 3p) | |
| 11 | +1 | Chris PONTIUS (Philadelphia Union) |
| 10 | +1 | Kei KAMARA (New England Revolution, 1p) |
| Chris WONDOLOWSKI (San Jose Earthquakes, 2p) | ||
| +1 | Jordan MORRIS (Seattle Sounders) | |
| Kevin MOLINO (Orlando City, 1p) | ||
| +1 | Didier DROGBA (Montréal Impact, 2p) | |
| 9 | Roland ALBERG (Philadelphia Union, 4p) | |
| +1 | Michael BARRIOS (FC Dallas) | |
| Yura MOVSISYAN (Real Salt Lake, 2p) | ||
| Joao PLATA (Real Salt Lake, 2p) |
| Friday, 16 September 2016 | |||||
| Chicago Fire | 2-2 | D.C. United | |||
| 22 | Cociș | 19 | Vincent | ||
| 29 | Accam | 90 | Boswell | ||
| Saturday, 17 September 2016 | |||||
| Colorado Rapids | 0-0 | San Jose Earthquakes | |||
| Montréal Impact | 1-3 | New England Revolution | |||
| 50(p) | Drogba | 1 | Kamara | ||
| 27 | Rowe | ||||
| 59 | Rowe | ||||
| Portland Timbers | 2-1 | Philadelphia Union | |||
| 46 | Valeri | 47 | Pontius | ||
| 53 | Adi | ||||
| Seattle Sounders | 1-0 | Vancouver Whitecaps | |||
| 81 | Morris | ||||
| Real Salt Lake | 0-1 | Houston Dynamo | |||
| 36 | Alex Lima | ||||
| Orlando City | 1-4 | Columbus Crew | |||
| 79 | Larin | 6 | Finlay | ||
| 22(og) | Hines | ||||
| 44 | Kamara | ||||
| 90 | Kamara | ||||
| New York City | 2-2 | FC Dallas | |||
| 8 | McNamara | 20 | Urruti | ||
| 78 | Shelton | 52 | Barrios | ||
| Sunday, 18 September 2016 | |||||
| Sporting Kansas City | 2-2 | LA Galaxy | |||
| 50 | Peterson | 7 | Gordon | ||
| 69 | Dwyer | 76 | Donovan | ||
| Toronto FC | 3-3 | New York Red Bulls | |||
| 41 | Bradley | 12(og) | Beitashour | ||
| 68 | Altidore | 31 | Wright-Phillips | ||
| 86 | Altidore | 48 | Wright-Phillips | ||
