| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 153 | 437 | 2.85 | 64 | 41.83% | 42 | 27.45% | 47 | 30.72% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Columbus Crew | 12 | 8 | 3 | 1 | 20 | 4 | +16 | 27 | WXWW | 6 | 6 | 0 | 0 | 12 | 0 | 6 | 2 | 3 | 1 | 8 | 4 | ||
| 2 | 2 | Orlando City | 12 | 6 | 4 | 2 | 23 | 14 | +9 | 22 | WWXX | 6 | 4 | 2 | 0 | 12 | 5 | 6 | 2 | 2 | 2 | 11 | 9 | |
| 3 | Toronto FC | 12 | 6 | 4 | 2 | 20 | 14 | +6 | 22 | XWLL | 6 | 3 | 2 | 1 | 7 | 3 | 6 | 3 | 2 | 1 | 13 | 11 | ||
| 4 | 2 | Philadelphia Union | 11 | 6 | 3 | 2 | 17 | 10 | +7 | 21 | WWLW | 5 | 4 | 1 | 0 | 10 | 4 | 6 | 2 | 2 | 2 | 7 | 6 | |
| 5 | 1 | New York City | 12 | 5 | 2 | 5 | 10 | 9 | +1 | 17 | OWOW | 5 | 3 | 0 | 2 | 7 | 6 | 7 | 2 | 2 | 3 | 3 | 3 | |
| 6 | 1 | Montréal Impact | 11 | 5 | 1 | 5 | 17 | 16 | +1 | 16 | LWLW | 7 | 3 | 0 | 4 | 9 | 9 | 4 | 2 | 1 | 1 | 8 | 7 | |
| 7 | 1 | New England Revolution | 12 | 3 | 6 | 3 | 10 | 11 | -1 | 15 | OLWL | 5 | 0 | 4 | 1 | 2 | 4 | 7 | 3 | 2 | 2 | 8 | 7 | |
| 8 | 1 | New York Red Bulls | 12 | 4 | 2 | 6 | 9 | 14 | -5 | 14 | LWLL | 5 | 2 | 0 | 3 | 4 | 7 | 7 | 2 | 2 | 3 | 5 | 7 | |
| 9 | Nashville | 11 | 3 | 3 | 5 | 9 | 13 | -4 | 12 | LWOX | 4 | 2 | 1 | 1 | 7 | 5 | 7 | 1 | 2 | 4 | 2 | 8 | ||
| 10 | 3 | FC Cincinnati | 12 | 3 | 3 | 6 | 8 | 17 | -9 | 12 | WLLO | 5 | 1 | 3 | 1 | 2 | 4 | 7 | 2 | 0 | 5 | 6 | 13 | |
| 11 | 3 | Inter Miami | 12 | 3 | 2 | 7 | 11 | 15 | -4 | 11 | WLWO | 4 | 2 | 1 | 1 | 5 | 4 | 8 | 1 | 1 | 6 | 6 | 11 | |
| 12 | 2 | Atlanta United | 12 | 3 | 2 | 7 | 12 | 17 | -5 | 11 | LLLX | 8 | 2 | 1 | 5 | 6 | 9 | 4 | 1 | 1 | 2 | 6 | 8 | |
| 13 | 2 | D.C. United | 12 | 2 | 5 | 5 | 11 | 17 | -6 | 11 | XLOW | 7 | 1 | 3 | 3 | 7 | 10 | 5 | 1 | 2 | 2 | 4 | 7 | |
| 14 | 2 | Chicago Fire | 12 | 2 | 3 | 7 | 12 | 22 | -10 | 9 | LXLO | 6 | 2 | 1 | 3 | 8 | 9 | 6 | 0 | 2 | 4 | 4 | 13 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Seattle Sounders | 11 | 6 | 3 | 2 | 26 | 10 | +16 | 21 | WWLX | 8 | 5 | 2 | 1 | 20 | 6 | 3 | 1 | 1 | 1 | 6 | 4 | |
| 2 | 1 | Sporting Kansas City | 12 | 6 | 2 | 4 | 23 | 18 | +5 | 20 | LWLX | 7 | 3 | 1 | 3 | 14 | 13 | 5 | 3 | 1 | 1 | 9 | 5 | |
| 3 | 6 | FC Dallas | 11 | 5 | 4 | 2 | 19 | 12 | +7 | 19 | WWWL | 7 | 4 | 2 | 1 | 13 | 6 | 4 | 1 | 2 | 1 | 6 | 6 | |
| 4 | 1 | Minnesota United | 12 | 5 | 3 | 4 | 23 | 19 | +4 | 18 | XLWW | 3 | 2 | 0 | 1 | 8 | 4 | 9 | 3 | 3 | 3 | 15 | 15 | |
| 5 | 1 | Portland Timbers | 12 | 5 | 3 | 4 | 25 | 24 | +1 | 18 | WXLW | 6 | 2 | 1 | 3 | 10 | 14 | 6 | 3 | 2 | 1 | 15 | 10 | |
| 6 | 4 | Colorado Rapids | 12 | 4 | 4 | 4 | 20 | 20 | +0 | 16 | WLWX | 5 | 1 | 3 | 1 | 7 | 9 | 7 | 3 | 1 | 3 | 13 | 11 | |
| 7 | 5 | Vancouver Whitecaps | 12 | 5 | 0 | 7 | 17 | 24 | -7 | 15 | WWLW | 5 | 2 | 0 | 3 | 12 | 14 | 7 | 3 | 0 | 4 | 5 | 10 | |
| 8 | 3 | LA Galaxy | 11 | 4 | 3 | 4 | 16 | 17 | -1 | 15 | LOWW | 6 | 2 | 1 | 3 | 8 | 8 | 5 | 2 | 2 | 1 | 8 | 9 | |
| 9 | 5 | Los Angeles | 12 | 4 | 3 | 5 | 25 | 27 | -2 | 15 | LWLL | 8 | 4 | 3 | 1 | 24 | 15 | 4 | 0 | 0 | 4 | 1 | 12 | |
| 10 | 3 | Houston Dynamo | 12 | 3 | 6 | 3 | 20 | 19 | +1 | 15 | XLXW | 5 | 2 | 3 | 0 | 8 | 4 | 7 | 1 | 3 | 3 | 12 | 15 | |
| 11 | 3 | Real Salt Lake | 12 | 3 | 5 | 4 | 17 | 21 | -4 | 14 | LLWL | 8 | 2 | 3 | 3 | 9 | 12 | 4 | 1 | 2 | 1 | 8 | 9 | |
| 12 | 1 | San Jose Earthquakes | 12 | 2 | 5 | 5 | 17 | 33 | -16 | 11 | LXOL | 6 | 0 | 4 | 2 | 7 | 15 | 6 | 2 | 1 | 3 | 10 | 18 | |
| 10 | Diego ROSSI (Los Angeles, 1p) | |
| 9 | +1 | Gyasi ZARDES (Columbus Crew) |
| 8 | +1 | Raúl RUIDÍAZ (Seattle Sounders, 1p) |
| 7 | +1 | Chris MUELLER (Orlando City) |
| 6 | Cristian PAVÓN (LA Galaxy, 3p) | |
| Jordan MORRIS (Seattle Sounders) | ||
| +1 | Kevin MOLINO (Minnesota United, 1p) | |
| +2 | Diego VALERI (Portland Timbers, 2p) | |
| +1 | Ayo AKINOLA (Toronto FC) | |
| 5 | +1 | Jeremy EBOBISSE (Portland Timbers) |
| +3 | Franco JARA (FC Dallas) | |
| +2 | Johnny RUSSELL (Sporting Kansas City) | |
| +1 | Rommel QUIOTO (Montréal Impact) | |
| Bradley WRIGHT-PHILLIPS (Los Angeles) | ||
| +1 | Darwin QUINTERO (Houston Dynamo) | |
| Kacper PRZYBYŁKO (Philadelphia Union) | ||
| Damir KREILACH (Real Salt Lake) |
| Wednesday, 16 September 2020 | |||||
| San Jose Earthquakes | 1-1 | Portland Timbers | |||
| 76 | Qazaishvili | 33 | Chará | ||
| Vancouver Whitecaps | 3-1 | Montréal Impact | |||
| 41(p) | Montero | 70 | Quioto | ||
| 44 | Dájome | ||||
| 78 | Montero | ||||
| FC Dallas | 4-1 | Colorado Rapids | |||
| 41 | Mosquera | 63 | André Bava | ||
| 49 | Jara | ||||
| 57 | Mosquera | ||||
| 78 | Mosquera | ||||
| Friday, 18 September 2020 | |||||
| Seattle Sounders | 3-0 | Los Angeles | |||
| 29(p) | Lodeiro | ||||
| 33(p) | Lodeiro | ||||
| 82 | Ruidíaz | ||||
| Saturday, 19 September 2020 | |||||
| New England Revolution | 0-0 | New York City | |||
| New York Red Bulls | 0-1 | FC Cincinnati | |||
| 85 | Medunjanin | ||||
| LA Galaxy | 0-2 | Colorado Rapids | |||
| 40 | Bassett | ||||
| 78 | Lewis | ||||
| Atlanta United | 1-2 | Inter Miami | |||
| 5 | Gallagher | 2 | Agudelo | ||
| 11 | Shea | ||||
| Real Salt Lake | 1-2 | Vancouver Whitecaps | |||
| 81 | Meram | 53 | Milinković | ||
| 84 | Cavallini | ||||
| San Jose Earthquakes | 1-6 | Portland Timbers | |||
| 44 | Fierro | 25(p) | Valeri | ||
| 27 | Ebobisse | ||||
| 57 | Valeri | ||||
| 70 | Chará | ||||
| 85 | Cascante | ||||
| 87 | Niezgoda | ||||
| Columbus Crew | 2-0 | Nashville | |||
| 50 | Pedro Santos | ||||
| 90 | Zardes | ||||
| D.C. United | 2-2 | Toronto FC | |||
| 5 | Kamara | 17 | Pozuelo | ||
| 88 | Yow | 60 | Akinola | ||
| Houston Dynamo | 2-2 | Minnesota United | |||
| 58 | Quintero | 11 | Molino | ||
| 69 | Figueroa | 45 | Lod | ||
| Sporting Kansas City | 2-3 | FC Dallas | |||
| 53 | Russell | 42 | Jara | ||
| 83 | Russell | 48 | Jara | ||
| 86 | Hollingshead | ||||
| Orlando City | 4-1 | Chicago Fire | |||
| 11 | Mueller | 48(p) | Berić | ||
| 24 | Nani | ||||
| 78 | Júnior Urso | ||||
| 90 | Michel | ||||