| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
| 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| Season archive |
| Saturday, 19 September 2020 | |||||
| North Carolina | - | Charlotte Independence | |||
| San Antonio | - | OKC Energy | |||
| Phoenix Rising | - | San Diego Loyal | |||
| Sacramento Republic | - | Tacoma Defiance | |||
| Louisville City | - | Memphis 901 | |||
| Saint Louis | - | Sporting Kansas City-2 | |||
| RGV Toros | - | FC Tulsa | |||
| El Paso Locomotive | - | Real Monarchs | |||
| New Mexico United | - | Colorado Springs | |||
| Loudoun United | - | Pittsburgh Riverhounds | |||
| Sunday, 20 September 2020 | |||||
| Charleston Battery | - | Miami FC | |||
| Portland Timbers-2 | - | Reno 1868 | |||
| Hartford Athletic | - | Philadelphia Union-2 | |||
| Tuesday, 22 September 2020 | |||||
| Austin Bold | - | Sporting Kansas City-2 | |||
| Wednesday, 23 September 2020 | |||||
| Indy Eleven | - | Saint Louis | |||
| LA Galaxy-2 | - | San Diego Loyal | |||
| Charlotte Independence | - | Miami FC | |||
| Philadelphia Union-2 | - | Hartford Athletic | |||
| Atlanta United-2 | - | New York-2 | |||
| Memphis 901 | - | North Carolina | |||
| New Mexico United | - | RGV Toros | |||