Results| Tuesday, 26 August 2025 |
| r3l1 | Junior | 2-0 | Atlético FC |
|
| r3l1 | Pereira | 4-3 | Real Cundinamarca |
|
| Wednesday, 27 August 2025 |
| r3l1 | Nacional | 4-0 | Quindio |
|
| r3l1 | Bucaramanga | 1-0 | América |
|
| r3l1 | Fortaleza | 0-0 | Medellín |
|
| Thursday, 28 August 2025 |
| r3l1 | Deportivo Pasto | 1-2 | Once Caldas |
|
| r3l1 | Alianza | 1-1 | Santa Fé |
|
| Tuesday, 2 September 2025 |
| r3l2 | Real Cundinamarca | 2-1 | Pereira | 5-5, p3-4 |
| r3l2 | Atlético FC | 2-0 | Junior | 2-2, p1-4 |
| Wednesday, 3 September 2025 |
| r3l1 | Envigado | P-P | Millonarios |
|
| r3l2 | América | 2-0 | Bucaramanga | 2-1 |
| r3l2 | Medellín | 2-1 | Fortaleza | 2-1 |
| r3l2 | Quindio | 2-2 | Nacional | 2-6 |
| Tuesday, 9 September 2025 |
| r3l2 | Santa Fé | 4-1 | Alianza | 5-2 |
| Tuesday, 16 September 2025 |
| r3l2 | Millonarios | 0-0 | Envigado | 0-0p?-? |
| Wednesday, 1 October 2025 |
| r3l2 | Once Caldas | 4-0 | Deportivo Pasto | 6-1 |
Copa Colombia
