| ROUND | R1 | R2 | R3 | QF | SF | F | ||||
| l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | |||
| Season archive |
| Tuesday, 16 March 2021 | |||||
| r1l1 |  Tolima | 3-0 | Cali | ||
| 9 | Miranda | ||||
| 12(p) | Mosquera | ||||
| 67 | Campaz | ||||
| r1l1 |  Antofagasta | 0-1 | Huachipato | ||
| 90(p) | Sepúlveda | ||||
| r1l1 |  12 de Octubre | 0-0 | Nacional | ||
| r1l1 |  Macará | 2-2 | Emelec | ||
| 27 | Orlando | 20 | Barceló | ||
| 89 | Santacruz | 34 | Zapata | ||
| Wednesday, 17 March 2021 | |||||
| r1l1 |  Guabirá | 4-1 | Nacional Potosí | ||
| 37 | Hurtado | 26(p) | Gularte | ||
| 74 | Hoyos | ||||
| 76 | Peredo | ||||
| 90 | Vogliotti | ||||
| r1l1 | Jorge Wilstermann | 2-1 | Atlético Palmaflor | ||
| 8 | Villarroel | 76 | Saldias | ||
| 38 | Osorio | ||||
| r1l1 |  Aragua | 0-1 | Mineros | ||
| 81 | Alcócer | ||||
| r1l1 |  UTC | 0-1 | Sport Huancayo | ||
| 74 | Balta | ||||
| Thursday, 18 March 2021 | |||||
| r1l1 | Aucas | 2-1 | Guayaquil City | ||
| 38(p) | Fydriszewski | 27 | Parrales | ||
| 90 | Fydriszewski | ||||
| r1l1 | Cobresal | 0-0 | Palestino | ||
| r1l1 | La Equidad | 1-2 | Deportivo Pasto | ||
| 10 | Fuentes | 36(og) | García | ||
| 66 | Medina | ||||
| r1l1 | Carlos A.Mannucci | 1-2 | FBC Melgar | ||
| 90 | Fernández | 11 | Bordacahar | ||
| 40 | Bordacahar | ||||
| r1l1 | Metropolitanos | 2-0 | Puerto Cabello | ||
| 39 | Larotonda | ||||
| 56 | Flores | ||||
| r1l1 | Guaireña | 1-2 | River Plate | ||
| 52 | González | 61 | Zeballos | ||
| 90 | Otazú | ||||
| Tuesday, 6 April 2021 | |||||
| r1l1 |  Cerro Largo | 2-2 | Peñarol | ||
| 72(p) | Estol | 21 | Formiliano | ||
| 90 | Borges | 50 | Terans | ||
| Wednesday, 7 April 2021 | |||||
| r1l1 | Torque | 0-0 | Fénix | ||
| 2 | +2 | Francisco FYDRISZEWSKI (Aucas, 1p) |
| +2 | Cristian BORDACAHAR (FBC Melgar) |
