| ROUND | R1 | R2 | |
| l1 | l2 | ||
| Season archive |
| Group A | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Lanús | 5 | 2 | 2 | 1 | 6 | 4 | +2 | 8 | LXWW | ||
| 2 | Barcelona | 5 | 2 | 2 | 1 | 9 | 8 | +1 | 8 | XXWL | ||
| 3 | Wanderers | 5 | 2 | 1 | 2 | 6 | 7 | -1 | 7 | WWLX | ||
| 4 | Metropolitanos | 5 | 0 | 3 | 2 | 3 | 5 | -2 | 3 | XLLX | ||
| Thursday, 7 April 2022 | |||||
| g |  Barcelona | 4-2 | Wanderers | ||
| 9 | Mastriani | 14 | Rivero | ||
| 11 | Mastriani | 62 | Méndez | ||
| 35 | Carcelén | ||||
| 54 | Diaz | ||||
| g |  Metropolitanos | 0-0 | Lanús | ||
| Thursday, 14 April 2022 | |||||
| g | Lanús | 3-1 | Barcelona | ||
| 31 | Cabral | 77 | Rodríguez | ||
| 74 | Sand | ||||
| 82 | Bernabei | ||||
| g | Wanderers | 1-1 | Metropolitanos | ||
| 45 | Méndez | 43(p) | Flores | ||
| Thursday, 28 April 2022 | |||||
| g | Wanderers | 0-1 | Lanús | ||
| 79 | Sand | ||||
| g | Barcelona | 1-0 | Metropolitanos | ||
| 33 | Molina | ||||
| Wednesday, 4 May 2022 | |||||
| g | Barcelona | 1-1 | Lanús | ||
| 41(og) | Sand | 53 | Sand | ||
| g | Metropolitanos | 0-1 | Wanderers | ||
| 45 | Méndez | ||||
| Thursday, 19 May 2022 | |||||
| g | Lanús | 1-2 | Wanderers | ||
| 84 | Bernabei | 87 | Méndez | ||
| 90 | Bravo | ||||
| g | Metropolitanos | 2-2 | Barcelona | ||
| 35 | Gómez | 45(p) | Diaz | ||
| 78 | Antón | 52 | Garcés | ||
| Wednesday, 25 May 2022 | |||||
| g | Lanús | - | Metropolitanos | ||
| g | Wanderers | - | Barcelona | ||
| Group B | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Racing Club | 5 | 4 | 0 | 1 | 7 | 4 | +3 | 12 | WWLW | ||
| 2 | FBC Melgar | 5 | 3 | 0 | 2 | 7 | 5 | +2 | 9 | LWWW | ||
| 3 | Cuiabá | 5 | 2 | 0 | 3 | 6 | 7 | -1 | 6 | WLLL | ||
| 4 | River Plate | 5 | 1 | 0 | 4 | 4 | 8 | -4 | 3 | LLWL | ||
| Thursday, 7 April 2022 | |||||
| g | River Plate | 0-1 | Racing Club | ||
| 90 | Miranda | ||||
| g |  Cuiabá | 2-0 | FBC Melgar | ||
| 78 | Élton | ||||
| 90 | Élton | ||||
| Wednesday, 13 April 2022 | |||||
| g | Racing Club | 2-0 | Cuiabá | ||
| 27 | Correa | ||||
| 65(og) | João Carlos | ||||
| g | FBC Melgar | 2-0 | River Plate | ||
| 3 | Cuesta | ||||
| 78 | Cuesta | ||||
| Wednesday, 27 April 2022 | |||||
| g | FBC Melgar | 3-1 | Racing Club | ||
| 21 | Iberíco | 86 | Correa | ||
| 52 | Iberíco | ||||
| 73 | Cuesta | ||||
| g | Cuiabá | 1-2 | River Plate | ||
| 48 | Marquinhos | 15 | Salaberry | ||
| 45 | López | ||||
| Tuesday, 3 May 2022 | |||||
| g | River Plate | 1-2 | FBC Melgar | ||
| 90 | Lavega | 22 | Cuesta | ||
| 90 | Archimbaud | ||||
| g | Cuiabá | 1-2 | Racing Club | ||
| 29 | Marllon | 47 | Moreno | ||
| 59 | Copetti | ||||
| Wednesday, 18 May 2022 | |||||
| g | Racing Club | 1-0 | FBC Melgar | ||
| 44 | Chancalay | ||||
| g | River Plate | 1-2 | Cuiabá | ||
| 90 | Clär | 43 | André Luis | ||
| 90 | André Luis | ||||
| Thursday, 26 May 2022 | |||||
| g | Racing Club | - | River Plate | ||
| g | FBC Melgar | - | Cuiabá | ||
| Group C | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Santos | 5 | 3 | 1 | 1 | 6 | 4 | +2 | 10 | WWXW | ||
| 2 | Unión La Calera | 5 | 2 | 2 | 1 | 3 | 2 | +1 | 8 | LWXW | ||
| 3 | Universidad Católica | 5 | 1 | 2 | 2 | 5 | 5 | +0 | 5 | XLWL | ||
| 4 | Banfield | 5 | 1 | 1 | 3 | 2 | 5 | -3 | 4 | XLLL | ||
| Tuesday, 5 April 2022 | |||||
| g | Banfield | 1-0 | Santos | ||
| 44 | Urzi | ||||
| g | Universidad Católica | 0-0 | Unión La Calera | ||
| Wednesday, 13 April 2022 | |||||
| g | Santos | 3-2 | Universidad Católica | ||
| 15 | Julio | 26 | Borja | ||
| 78(p) | Léo Baptistão | 42 | Minda | ||
| 85 | Angulo | ||||
| Thursday, 14 April 2022 | |||||
| g | Unión La Calera | 1-0 | Banfield | ||
| 10 | Sáez | ||||
| Wednesday, 27 April 2022 | |||||
| g | Universidad Católica | 2-0 | Banfield | ||
| 51 | Díaz | ||||
| 54 | Borja | ||||
| Thursday, 28 April 2022 | |||||
| g | Unión La Calera | 1-1 | Santos | ||
| 26 | Valencia | 10 | Angulo | ||
| Thursday, 5 May 2022 | |||||
| g | Banfield | 0-1 | Unión La Calera | ||
| 76 | Sáez | ||||
| g | Universidad Católica | 0-1 | Santos | ||
| 90 | Rwan | ||||
| Tuesday, 17 May 2022 | |||||
| g | Banfield | 1-1 | Universidad Católica | ||
| 82 | Dátolo | 90 | Díaz | ||
| Wednesday, 18 May 2022 | |||||
| g | Santos | 1-0 | Unión La Calera | ||
| 90 | Lucas Barbosa | ||||
| Tuesday, 24 May 2022 | |||||
| g | Santos | - | Banfield | ||
| g | Unión La Calera | - | Universidad Católica | ||
| Group D | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | São Paulo | 5 | 4 | 1 | 0 | 11 | 3 | +8 | 13 | WOWW | ||
| 2 | Everton | 5 | 2 | 2 | 1 | 5 | 4 | +1 | 8 | WOWL | ||
| 3 | Ayacucho FC | 5 | 1 | 1 | 3 | 5 | 7 | -2 | 4 | LOLW | ||
| 4 | Jorge Wilstermann | 5 | 0 | 2 | 3 | 2 | 9 | -7 | 2 | LOLL | ||
| Tuesday, 5 April 2022 | |||||
| g | Everton | 1-1 | Jorge Wilstermann | ||
| 47 | Di Yorio | 23(p) | Osorio | ||
| Thursday, 7 April 2022 | |||||
| g | Ayacucho FC | 2-3 | São Paulo | ||
| 7 | Barrios | 3 | Arboleda | ||
| 20 | Techera | 23 | Miranda | ||
| 88(p) | Luciano | ||||
| Wednesday, 13 April 2022 | |||||
| g | Jorge Wilstermann | 0-2 | Ayacucho FC | ||
| 9 | Duclós | ||||
| 78 | Techera | ||||
| Thursday, 14 April 2022 | |||||
| g | São Paulo | 2-0 | Everton | ||
| 31 | Arboleda | ||||
| 87 | Talles Toledo | ||||
| Tuesday, 26 April 2022 | |||||
| g | Everton | 2-1 | Ayacucho FC | ||
| 55 | Echeverría | 61(p) | Techera | ||
| 71 | Echeverría | ||||
| Thursday, 28 April 2022 | |||||
| g | Jorge Wilstermann | 1-3 | São Paulo | ||
| 31(p) | Osorio | 23 | Igor Gomes | ||
| 64(p) | Reinaldo | ||||
| 85 | Marquinhos | ||||
| Thursday, 5 May 2022 | |||||
| g | Everton | 0-0 | São Paulo | ||
| g | Ayacucho FC | 0-0 | Jorge Wilstermann | ||
| Wednesday, 18 May 2022 | |||||
| g | Ayacucho FC | 0-2 | Everton | ||
| 58 | Di Yorio | ||||
| 66 | Campos | ||||
| Thursday, 19 May 2022 | |||||
| g | São Paulo | 3-0 | Jorge Wilstermann | ||
| 6 | Rodrigo Nestor | ||||
| 17 | Rodrigo Nestor | ||||
| 47 | Patrick | ||||
| Wednesday, 25 May 2022 | |||||
| g | São Paulo | - | Ayacucho FC | ||
| g | Jorge Wilstermann | - | Everton | ||
| Group E | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Internacional | 5 | 2 | 3 | 0 | 7 | 4 | +3 | 9 | WXWX | ||
| 2 | Guaireña | 5 | 2 | 3 | 0 | 9 | 7 | +2 | 9 | WXWX | ||
| 3 | 9 de Octubre | 5 | 1 | 1 | 3 | 8 | 10 | -2 | 4 | LWLL | ||
| 4 | Medellín | 5 | 1 | 1 | 3 | 7 | 10 | -3 | 4 | LLLW | ||
| Wednesday, 6 April 2022 | |||||
| g | 9 de Octubre | 2-2 | Internacional | ||
| 58 | Da Luz | 25 | Maurício | ||
| 75 | Da Luz | 26 | Wesley | ||
| Thursday, 7 April 2022 | |||||
| g |  Guaireña | 3-3 | Medellín | ||
| 6 | Otazú | 33 | Pons | ||
| 56 | Ayala | 38 | Arregui | ||
| 65(og) | Arboleda | 90 | Cuesta | ||
| Thursday, 14 April 2022 | |||||
| g | Medellín | 2-1 | 9 de Octubre | ||
| 9 | Hernández | 5 | Lucas | ||
| 90 | Castrillón | ||||
| g | Internacional | 1-1 | Guaireña | ||
| 78(og) | Paniagua | 41 | Otazú | ||
| Tuesday, 26 April 2022 | |||||
| g | Medellín | 0-1 | Internacional | ||
| 54 | Alexandre Alemão | ||||
| Wednesday, 27 April 2022 | |||||
| g | Guaireña | 1-0 | 9 de Octubre | ||
| 90(p) | Godoy | ||||
| Tuesday, 3 May 2022 | |||||
| g | 9 de Octubre | 3-2 | Medellín | ||
| 32 | Stephens | 36 | López | ||
| 57 | Becerra | 65 | Camargo | ||
| 69(p) | Stephens | ||||
| Thursday, 5 May 2022 | |||||
| g | Guaireña | 1-1 | Internacional | ||
| 33(p) | Otazú | 52 | Wamberto | ||
| Tuesday, 17 May 2022 | |||||
| g | Internacional | 2-0 | Medellín | ||
| 19 | Edenílson | ||||
| 57 | Edenílson | ||||
| g | 9 de Octubre | 2-3 | Guaireña | ||
| 7 | Da Luz | 52(p) | Otazú | ||
| 75 | Stephens | 62 | Otazú | ||
| 90 | Maciel | ||||
| Tuesday, 24 May 2022 | |||||
| g | Medellín | - | Guaireña | ||
| g | Internacional | - | 9 de Octubre | ||
| Group F | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Atlético-GO | 5 | 4 | 0 | 1 | 10 | 4 | +6 | 12 | WWLW | ||
| 2 | LDU Quito | 5 | 3 | 1 | 1 | 10 | 8 | +2 | 10 | XWWW | ||
| 3 | Defensa y Justicia | 5 | 1 | 1 | 3 | 8 | 9 | -1 | 4 | XLLL | ||
| 4 | Antofagasta | 5 | 1 | 0 | 4 | 4 | 11 | -7 | 3 | LLWL | ||
| Tuesday, 5 April 2022 | |||||
| g | Atlético-GO | 4-0 | LDU Quito | ||
| 62 | Jorginho | ||||
| 77 | Shaylon | ||||
| 87 | Hayner | ||||
| 90 | Rickson | ||||
| Wednesday, 6 April 2022 | |||||
| g | Antofagasta | 1-3 | Defensa y Justicia | ||
| 83 | Collao | 10 | Bou | ||
| 29 | Tripichio | ||||
| 57 | Merentiel | ||||
| Tuesday, 12 April 2022 | |||||
| g | LDU Quito | 4-0 | Antofagasta | ||
| 47 | Angulo | ||||
| 51(og) | Cornejo | ||||
| 77 | Molina | ||||
| 90 | Arce | ||||
| g | Defensa y Justicia | 0-1 | Atlético-GO | ||
| 9 | Rato | ||||
| Wednesday, 27 April 2022 | |||||
| g | Antofagasta | 2-1 | Atlético-GO | ||
| 87(p) | Flores | 45 | Rodrigues | ||
| 89 | López | ||||
| Thursday, 28 April 2022 | |||||
| g | Defensa y Justicia | 1-2 | LDU Quito | ||
| 82 | Albertengo | 55 | Alvarado | ||
| 87 | Alvarado | ||||
| Wednesday, 4 May 2022 | |||||
| g | Antofagasta | 1-2 | LDU Quito | ||
| 18 | López | 52 | Angulo | ||
| 67 | López | ||||
| g | Atlético-GO | 3-2 | Defensa y Justicia | ||
| 18(p) | Marlon Freitas | 65 | Fontana | ||
| 47 | Shaylon | 86 | Albertengo | ||
| 55(og) | Unsain | ||||
| Tuesday, 17 May 2022 | |||||
| g | Atlético-GO | 1-0 | Antofagasta | ||
| 12 | Jorginho | ||||
| Wednesday, 18 May 2022 | |||||
| g | LDU Quito | 2-2 | Defensa y Justicia | ||
| 5 | Quintero | 29 | Albertengo | ||
| 71 | Angulo | 45 | Albertengo | ||
| Tuesday, 24 May 2022 | |||||
| g | LDU Quito | - | Atlético-GO | ||
| g | Defensa y Justicia | - | Antofagasta | ||
| Group G | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Ceará | 5 | 5 | 0 | 0 | 15 | 1 | +14 | 15 | WWWW | ||
| 2 | Independiente | 5 | 4 | 0 | 1 | 13 | 2 | +11 | 12 | WWWW | ||
| 3 | Deportivo La Guaira | 5 | 0 | 1 | 4 | 1 | 12 | -11 | 1 | LLLL | ||
| 4 | General Caballero | 5 | 0 | 1 | 4 | 1 | 15 | -14 | 1 | LLLL | ||
| Tuesday, 5 April 2022 | |||||
| g | Ceará | 2-1 | Independiente | ||
| 61(p) | Mendoza | 32 | Togni | ||
| 67(og) | Benegas | ||||
| Wednesday, 6 April 2022 | |||||
| g | General Caballero | 1-1 | Deportivo La Guaira | ||
| 35 | Corulo | 49 | Cumana | ||
| Tuesday, 12 April 2022 | |||||
| g | Independiente | 2-0 | General Caballero | ||
| 66 | Benegas | ||||
| 73 | Soñora | ||||
| g | Deportivo La Guaira | 0-2 | Ceará | ||
| 6 | Vinicius | ||||
| 9 | Lima | ||||
| Tuesday, 26 April 2022 | |||||
| g | General Caballero | 0-2 | Ceará | ||
| 50(p) | Erick | ||||
| 69 | Messias | ||||
| g | Deportivo La Guaira | 0-2 | Independiente | ||
| 67 | Blanco | ||||
| 90 | Fernández | ||||
| Tuesday, 3 May 2022 | |||||
| g | Ceará | 3-0 | Deportivo La Guaira | ||
| 59 | Mendoza | ||||
| 67 | Vinicius | ||||
| 76 | Erick | ||||
| g | General Caballero | 0-4 | Independiente | ||
| 42(p) | Blanco | ||||
| 58 | Pozzo | ||||
| 87 | Fernández | ||||
| 90 | Soñora | ||||
| Tuesday, 17 May 2022 | |||||
| g | Ceará | 6-0 | General Caballero | ||
| 6 | Wescley | ||||
| 18 | Cléber | ||||
| 32 | Cléber | ||||
| 72 | Mendoza | ||||
| 78 | Mendoza | ||||
| 84 | Zé Roberto | ||||
| Thursday, 19 May 2022 | |||||
| g | Independiente | 4-0 | Deportivo La Guaira | ||
| 41(og) | Cumana | ||||
| 47 | Benegas | ||||
| 83 | Roa | ||||
| 90 | Benegas | ||||
| Wednesday, 25 May 2022 | |||||
| g | Independiente | - | Ceará | ||
| g | Deportivo La Guaira | - | General Caballero | ||
| Group H | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Junior | 5 | 3 | 1 | 1 | 10 | 4 | +6 | 10 | WLWW | ||
| 2 | Unión | 5 | 2 | 3 | 0 | 6 | 2 | +4 | 9 | OWOW | ||
| 3 | Fluminense | 5 | 2 | 2 | 1 | 5 | 4 | +1 | 8 | OWOL | ||
| 4 | Oriente Petrolero | 5 | 0 | 0 | 5 | 2 | 13 | -11 | 0 | LLLL | ||
| Wednesday, 6 April 2022 | |||||
| g | Fluminense | 3-0 | Oriente Petrolero | ||
| 31 | Cristiano | ||||
| 39 | Arias | ||||
| 73(og) | Zazpe | ||||
| g | Unión | 1-1 | Junior | ||
| 3 | Vera | 6(og) | Vera | ||
| Tuesday, 12 April 2022 | |||||
| g | Oriente Petrolero | 1-3 | Unión | ||
| 90 | Dorrego | 4 | Calderón | ||
| 71 | Peralta Bauer | ||||
| 90 | Juárez | ||||
| Wednesday, 13 April 2022 | |||||
| g | Junior | 3-0 | Fluminense | ||
| 10 | Moreno | ||||
| 45(p) | Borja | ||||
| 90 | Sambueza | ||||
| Tuesday, 26 April 2022 | |||||
| g | Fluminense | 0-0 | Unión | ||
| Thursday, 28 April 2022 | |||||
| g | Oriente Petrolero | 1-3 | Junior | ||
| 51 | Guaycochea | 36 | Albornoz | ||
| 67 | Albornoz | ||||
| 90 | Hinestroza | ||||
| Wednesday, 4 May 2022 | |||||
| g | Fluminense | 2-1 | Junior | ||
| 4 | Ganso | 55 | Borja | ||
| 73 | Luiz Henrique | ||||
| Thursday, 5 May 2022 | |||||
| g | Unión | 2-0 | Oriente Petrolero | ||
| 12 | Luna Diale | ||||
| 56 | Roldán | ||||
| Tuesday, 17 May 2022 | |||||
| g | Junior | 2-0 | Oriente Petrolero | ||
| 23(p) | Borja | ||||
| 28 | Borja | ||||
| Thursday, 19 May 2022 | |||||
| g | Unión | 0-0 | Fluminense | ||
| Thursday, 26 May 2022 | |||||
| g | Oriente Petrolero | - | Fluminense | ||
| g | Junior | - | Unión | ||
| 6 | +4 | Bernardo CUESTA (FBC Melgar, 1p) |
| 5 | +4 | Miguel BORJA (Junior, 2p) |
| +5 | Mario OTAZÚ (Guaireña, 2p) | |
| 4 | +4 | Mauro MÉNDEZ (Wanderers) |
| +3 | Cristian TECHERA (Ayacucho FC, 1p) | |
| +4 | Stiven MENDOZA (Ceará, 1p) | |
| +2 | Alexander ALVARADO (LDU Quito) | |
| +4 | Lucas ALBERTENGO (Defensa y Justicia) | |
| 3 | +3 | Nilson ANGULO (LDU Quito) |
| +3 | Mauro DA LUZ (9 de Octubre) | |
| Facundo SUÁREZ (Oriente Petrolero) | ||
| +3 | Leandro BENEGAS (Independiente) | |
| +2 | Sebastián SÁEZ (Unión La Calera) | |
| +3 | Alfredo STEPHENS (9 de Octubre, 1p) | |
| +3 | José SAND (Lanús) |
