 Real Madriz Futbol Clube |
| 20-Mar-2022 | LP (11) | Real Estelí | 4-0 | Real Madriz |
| 02-Apr-2022 | LP (12) | Juventus | 1-1 | Real Madriz |
| 07-Apr-2022 | LP (13) | UNAN | 3-1 | Real Madriz |
| 10-Apr-2022 | LP (14) | Real Madriz | 0-1 | Deportivo Ocotal |
| 14-Apr-2022 | LP (15) | Real Madriz | 2-2 | Diriangén |
| 27-Apr-2022 | LP (17) | Managua | 3-0 | Real Madriz |
| 28-Apr-2022 | LP (16) | Real Madriz | 3-0 | ART Jalapa |
| 01-May-2022 | LP (18) | Real Madriz | 0-0 | Sébaco |
