Primera A| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | Apertura |
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | Finalización |
| Season archive |
| Games | Goals | H | D | A | ||||
| 147 | 336 | 2.28 | 61 | 41.50% | 42 | 28.57% | 44 | 29.93% |
| Finalización | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
 | 1 |  | Nacional | 14 | 10 | 3 | 1 | 27 | 10 | +17 | 33 | XWLX | 7 | 5 | 2 | 0 | 9 | 2 | 7 | 5 | 1 | 1 | 18 | 8 |
| 2 | | Millonarios | 15 | 10 | 2 | 3 | 29 | 15 | +14 | 32 | WWOW | 8 | 6 | 1 | 1 | 13 | 4 | 7 | 4 | 1 | 2 | 16 | 11 |
| 3 | | Tolima | 15 | 7 | 7 | 1 | 17 | 7 | +10 | 28 | XWWO | 7 | 4 | 3 | 0 | 7 | 2 | 8 | 3 | 4 | 1 | 10 | 5 |
| 4 |  1 | Pereira | 15 | 8 | 3 | 4 | 20 | 15 | +5 | 27 | WWWW | 7 | 3 | 2 | 2 | 9 | 7 | 8 | 5 | 1 | 2 | 11 | 8 |
| 5 |  1 | Junior | 15 | 6 | 6 | 3 | 20 | 18 | +2 | 24 | LWXW | 7 | 5 | 1 | 1 | 12 | 6 | 8 | 1 | 5 | 2 | 8 | 12 |
| 6 | 1 | Envigado | 15 | 6 | 5 | 4 | 19 | 16 | +3 | 23 | XWOL | 7 | 4 | 2 | 1 | 14 | 9 | 8 | 2 | 3 | 3 | 5 | 7 |
| 7 | 1 | Alianza Petrolera | 15 | 6 | 4 | 5 | 20 | 15 | +5 | 22 | LWLX | 7 | 4 | 1 | 2 | 12 | 7 | 8 | 2 | 3 | 3 | 8 | 8 |
| 8 | | Jaguares | 15 | 6 | 4 | 5 | 21 | 20 | +1 | 22 | XLWX | 8 | 3 | 3 | 2 | 13 | 11 | 7 | 3 | 1 | 3 | 8 | 9 |
| 9 | 3 | Bucaramanga | 15 | 6 | 3 | 6 | 22 | 24 | -2 | 21 | WLXL | 8 | 3 | 2 | 3 | 14 | 14 | 7 | 3 | 1 | 3 | 8 | 10 | |
| 10 | | Medellín | 15 | 4 | 8 | 3 | 12 | 11 | +1 | 20 | XXOW | 8 | 3 | 5 | 0 | 9 | 4 | 7 | 1 | 3 | 3 | 3 | 7 | |
| 11 | 2 | Quindio | 15 | 6 | 2 | 7 | 16 | 16 | +0 | 20 | WLLL | 8 | 5 | 0 | 3 | 13 | 10 | 7 | 1 | 2 | 4 | 3 | 6 | |
| 12 | 3 | América | 14 | 5 | 4 | 5 | 14 | 13 | +1 | 19 | XOWL | 7 | 3 | 2 | 2 | 8 | 6 | 7 | 2 | 2 | 3 | 6 | 7 | |
| 13 | 2 | Cali | 14 | 4 | 6 | 4 | 17 | 19 | -2 | 18 | XXWW | 7 | 1 | 4 | 2 | 8 | 9 | 7 | 3 | 2 | 2 | 9 | 10 | |
| 14 | | Santa Fé | 14 | 4 | 5 | 5 | 13 | 15 | -2 | 17 | LWOW | 7 | 1 | 2 | 4 | 6 | 10 | 7 | 3 | 3 | 1 | 7 | 5 | |
| 15 | | Rionegro | 14 | 5 | 1 | 8 | 16 | 19 | -3 | 16 | LWLL | 7 | 3 | 0 | 4 | 8 | 8 | 7 | 2 | 1 | 4 | 8 | 11 | |
| 16 | | La Equidad | 15 | 3 | 6 | 6 | 13 | 17 | -4 | 15 | LLXW | 7 | 2 | 4 | 1 | 5 | 5 | 8 | 1 | 2 | 5 | 8 | 12 | |
| 17 | | Deportivo Pasto | 15 | 3 | 3 | 9 | 10 | 20 | -10 | 12 | LWLL | 7 | 2 | 0 | 5 | 5 | 9 | 8 | 1 | 3 | 4 | 5 | 11 | |
| 18 | 1 | Once Caldas | 15 | 3 | 3 | 9 | 13 | 25 | -12 | 12 | WLLW | 8 | 2 | 2 | 4 | 7 | 11 | 7 | 1 | 1 | 5 | 6 | 14 | |
| 19 | 1 | Patriotas | 15 | 2 | 5 | 8 | 7 | 17 | -10 | 11 | LWLL | 8 | 1 | 3 | 4 | 2 | 8 | 7 | 1 | 2 | 4 | 5 | 9 | |
| 20 | | Huila | 14 | 1 | 4 | 9 | 10 | 24 | -14 | 7 | LLLX | 7 | 1 | 3 | 3 | 8 | 12 | 7 | 0 | 1 | 6 | 2 | 12 | |
| Sunday, 17 October 2021 | ||||||
| 14 | Santa Fé | 0-2 | Millonarios | |||
| 14 | Junior | 2-1 | Jaguares | |||
| 14 | Deportivo Pasto | 1-0 | Quindio | |||
| 14 | Alianza Petrolera | 2-0 | Bucaramanga | |||
| Monday, 18 October 2021 | ||||||
| 14 | Envigado | 4-1 | Rionegro | |||
| Thursday, 21 October 2021 | ||||||
| 15 | Once Caldas | 2-1 | La Equidad | |||
| Friday, 22 October 2021 | ||||||
| 15 | Quindio | 1-0 | Alianza Petrolera | |||
| 15 | Jaguares | 1-1 | Envigado | |||
| Saturday, 23 October 2021 | ||||||
| 15 | Patriotas | 1-2 | Pereira | |||
| 15 | Millonarios | 4-1 | Junior | |||
| 15 | Medellín | 2-2 | Tolima | |||
| 15 | Bucaramanga | 2-1 | Deportivo Pasto | |||
| Sunday, 24 October 2021 | ||||||
| 15 | América | - | Nacional | |||
| 15 | Huila | - | Santa Fé | |||
| 15 | Rionegro | - | Cali | |||
| Tuesday, 26 October 2021 | ||||||
| 16 | Envigado | - | Millonarios | |||
| 16 | Pereira | - | Bucaramanga | |||
| 16 | Alianza Petrolera | - | Medellín | |||
| Wednesday, 27 October 2021 | ||||||
| 16 | Nacional | - | Once Caldas | |||
| 16 | Cali | - | Patriotas | |||
| 16 | La Equidad | - | Rionegro | |||
| Thursday, 28 October 2021 | ||||||
| 16 | Santa Fé | - | Jaguares | |||
| 16 | Tolima | - | América | |||
| 16 | Junior | - | Quindio | |||
| 16 | Deportivo Pasto | - | Huila | |||
| 19 | Jefferson DUQUE (Nacional, 9p) |
| 15 | Fernando URIBE (Millonarios, 1p) |
| 10 | Agustín VULETICH (Medellín, 2p) |
| Diego HERAZO (Medellín, 4p) | |
| 9 | Jarlan BARRERA (Nacional, 1p) |
| Kelvin OSORIO (Santa Fé) | |
| Jhord GARCÉS (Alianza Petrolera, 2p) | |
| 8 | Pablo ROJAS (Jaguares, 4p) |
| Brayan FERNÁNDEZ (Bucaramanga, 2p) | |
| 7 | Cristian ARANGO (Millonarios, 2p) |
| Alejandro QUINTANA (Bucaramanga) | |
| Anderson PLATA (Tolima) | |
| 6 | Andrés RENTERÍA (Jaguares) |
| Baldomero PERLAZA (Nacional) | |
| Miguel BORJA (Junior, 1p) | |
| Pablo BUENO (Alianza Petrolera) | |
| Sergio MOSQUERA (Tolima, 3p) | |
| Christian MARRUGO (Rionegro, 2p) | |
| Juan CAICEDO (Tolima) | |
| Luis GONZÁLEZ (Junior, 1p) | |
| Brayan MORENO (Chicó) | |
| Jesús ARRIETA (Patriotas) | |
| Wilfrido DE LA ROSA (Pereira) | |
| Juan PÉREZ (Once Caldas, 2p) | |
| Yeison GUZMÁN (Nacional, 1p) | |
| David LEMOS (Once Caldas, 3p) |
