| ROUND | R1 | R2 | QF | SF | F | |||||
| l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | |
| Season archive |
| Tuesday, 21 September 2021 | ||||||
| r2l1 |  Guastatoya | 1-1 | Alajuelense | |||
| r2l1 |  Forge | 0-0 | Independiente | |||
| r2l1 |  Inter Moengotapoe | 0-6 | Olimpia | |||
| Wednesday, 22 September 2021 | ||||||
| r2l1 | Comunicaciones | 2-1 | Alianza | |||
| Thursday, 23 September 2021 | ||||||
| r2l1 | Santos | 1-0 | Plaza Amador | |||
| r2l1 | Marathón | 2-0 | Real Estelí | |||
| r2l1 | Universitario | 2-2 | Motagua | |||
| r2l1 | Santa Lucía Cotzumalguapa | 0-2 | Saprissa | |||
| Tuesday, 28 September 2021 | ||||||
| r2l2 | Olimpia | - | Inter Moengotapoe | 6-0 | ||
| r2l2 | Alajuelense | 2-2 | Guastatoya | 3-3 | ||
| r2l2 | Independiente | 0-2 | Forge | 0-2 | ||
| Wednesday, 29 September 2021 | ||||||
| r2l2 | Alianza | 0-1 | Comunicaciones | 1-3 | ||
| r2l2 | Plaza Amador | 0-2 | Santos | 0-3 | ||
| r2l2 | Real Estelí | 2-0 | Marathón | 2-2p?-? | ||
| Thursday, 30 September 2021 | ||||||
| r2l2 | Saprissa | 4-2 | Santa Lucía Cotzumalguapa | 6-2 | ||
| r2l2 | Motagua | 1-0 | Universitario | 3-2 | ||
| 3 | +2 | Júnior LACAYO (Comunicaciones) |
| +1 | Isaác ACUÑA (Santa Lucía Cotzumalguapa, 1p) | |
| 2 | Osvaldo RODRÍGUEZ (Santos, 1p) | |
| +1 | Mo BABOULI (Forge) | |
| +1 | Mario MARTÍNEZ (Marathón, 1p) | |
| +2 | Adrián MARTINEZ (Alajuelense) | |
| +2 | Cristian BOLAÑOS (Saprissa) | |
| +2 | Eddie HERNÁNDEZ (Olimpia) | |
| +2 | Jossimar MÉNDEZ (Santos) | |
| +2 | Kevin LÓPEZ (Motagua) | |
| +2 | Luis LANDÍN (Guastatoya) | |
| +1 | Andres LEZCANO (Comunicaciones, 1p) |
