Qatar
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| Match dates |
| Wednesday, 24 March 2021 | |||||
| Belgium | 3-1 | Wales | |||
| Estonia | 2-6 | Czech Republic | |||
| Saturday, 27 March 2021 | |||||
| Belarus | 4-2 | Estonia | |||
| Czech Republic | 1-1 | Belgium | |||
| Tuesday, 30 March 2021 | |||||
| Belgium | 8-0 | Belarus | |||
| Wales | 1-0 | Czech Republic | |||
| Thursday, 2 September 2021 | |||||
| Czech Republic | 1-0 | Belarus | |||
| Estonia | 2-5 | Belgium | |||
| Sunday, 5 September 2021 | |||||
| Belgium | 3-0 | Czech Republic | |||
| Belarus | 2-3 | Wales | |||
| Wednesday, 8 September 2021 | |||||
| Belarus | 0-1 | Belgium | |||
| Wales | 0-0 | Estonia | |||
| Friday, 8 October 2021 | |||||
| Czech Republic | 2-2 | Wales | |||
| Estonia | 2-0 | Belarus | |||
| Monday, 11 October 2021 | |||||
| Belarus | 0-2 | Czech Republic | |||
| Estonia | 0-1 | Wales | |||
| Saturday, 13 November 2021 | |||||
| Belgium | 3-1 | Estonia | |||
| Wales | 5-1 | Belarus | |||
| Tuesday, 16 November 2021 | |||||
| Czech Republic | 2-0 | Estonia | |||
| Wales | 1-1 | Belgium | |||
| Group E | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 |  Belgium | 8 | 6 | 2 | 0 | 25 | 6 | +19 | 20 | XWWW | ||
| 2 |  Wales | 8 | 4 | 3 | 1 | 14 | 9 | +5 | 15 | XWWX | ||
| 3 |  Czech Republic | 8 | 4 | 2 | 2 | 14 | 9 | +5 | 14 | WWXL | ||
| 4 |  Estonia | 8 | 1 | 1 | 6 | 9 | 21 | -12 | 4 | LLLW | ||
| 5 |  Belarus | 8 | 1 | 0 | 7 | 7 | 24 | -17 | 3 | LLLL | ||
| 5 | Romelu LUKAKU (Belgium, 1p) |
| 3 | Hans VANAKEN (Belgium) |
| Erik SORGA (Estonia) | |
| Aaron RAMSEY (Wales, 1p) | |
| Tomáš SOUČEK (Czech Republic) | |
| Vitali LISAKOVICH (Belarus, 2p) | |
| Henri ANIER (Estonia) | |
| Gareth BALE (Wales, 2p) | |
| 2 | Kieffer MOORE (Wales) |
| Thorgan HAZARD (Belgium) | |
| Christian BENTEKE (Belgium) | |
| Dennis PRAET (Belgium) | |
| Daniel JAMES (Wales) | |
| Antonín BARÁK (Czech Republic) | |
| Patrik SCHICK (Czech Republic) | |
| Leandro TROSSARD (Belgium) | |
| Kevin DE BRUYNE (Belgium) |
