| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | Apertura 2021 |
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | Clausura 2022 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 153 | 332 | 2.16 | 59 | 38.56% | 54 | 35.29% | 40 | 26.14% |
| Apertura 2021 | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | América | 17 | 10 | 5 | 2 | 21 | 10 | +11 | 35 | OLWW | 9 | 7 | 2 | 0 | 13 | 2 | 8 | 3 | 3 | 2 | 8 | 8 | ||
| 2 | Atlas | 17 | 8 | 5 | 4 | 21 | 10 | +11 | 29 | WLWO | 9 | 4 | 2 | 3 | 8 | 5 | 8 | 4 | 3 | 1 | 13 | 5 | ||
| 3 | León | 17 | 8 | 5 | 4 | 20 | 14 | +6 | 29 | WWOW | 8 | 3 | 3 | 2 | 11 | 6 | 9 | 5 | 2 | 2 | 9 | 8 | ||
| 4 | Tigres | 17 | 7 | 7 | 3 | 26 | 14 | +12 | 28 | WWLW | 9 | 4 | 5 | 0 | 15 | 5 | 8 | 3 | 2 | 3 | 11 | 9 | ||
| 5 | 1 | Santos Laguna | 17 | 5 | 9 | 3 | 23 | 16 | +7 | 24 | OWWX | 9 | 2 | 6 | 1 | 9 | 7 | 8 | 3 | 3 | 2 | 14 | 9 | |
| 6 | 1 | Toluca | 17 | 6 | 6 | 5 | 22 | 22 | +0 | 24 | LOXX | 8 | 3 | 4 | 1 | 13 | 9 | 9 | 3 | 2 | 4 | 9 | 13 | |
| 7 | 2 | Puebla | 17 | 6 | 6 | 5 | 16 | 16 | +0 | 24 | WWLW | 9 | 3 | 3 | 3 | 9 | 9 | 8 | 3 | 3 | 2 | 7 | 7 | |
| 8 | 1 | Cruz Azul | 17 | 5 | 8 | 4 | 21 | 17 | +4 | 23 | LLWX | 8 | 3 | 3 | 2 | 11 | 7 | 9 | 2 | 5 | 2 | 10 | 10 | |
| 9 | 1 | Monterrey | 17 | 5 | 7 | 5 | 19 | 16 | +3 | 22 | OXLL | 8 | 4 | 2 | 2 | 10 | 4 | 9 | 1 | 5 | 3 | 9 | 12 | |
| 10 | 2 | Guadalajara | 17 | 5 | 7 | 5 | 13 | 13 | +0 | 22 | WLXO | 8 | 3 | 2 | 3 | 9 | 10 | 9 | 2 | 5 | 2 | 4 | 3 | |
| 11 | 4 | UNAM | 17 | 5 | 6 | 6 | 17 | 23 | -6 | 21 | WLXW | 9 | 4 | 3 | 2 | 11 | 10 | 8 | 1 | 3 | 4 | 6 | 13 | |
| 12 | 1 | Atlético San Luis | 17 | 4 | 8 | 5 | 19 | 23 | -4 | 20 | OOXL | 8 | 1 | 3 | 4 | 8 | 15 | 9 | 3 | 5 | 1 | 11 | 8 | |
| 13 | 2 | Mazatlán | 17 | 5 | 5 | 7 | 18 | 24 | -6 | 20 | LLWL | 9 | 4 | 3 | 2 | 13 | 12 | 8 | 1 | 2 | 5 | 5 | 12 | |
| 14 | 4 | Necaxa | 17 | 6 | 2 | 9 | 16 | 22 | -6 | 20 | LWWX | 8 | 4 | 0 | 4 | 10 | 10 | 9 | 2 | 2 | 5 | 6 | 12 | |
| 15 | 1 | Pachuca | 17 | 4 | 6 | 7 | 19 | 21 | -2 | 18 | LOXX | 9 | 2 | 5 | 2 | 10 | 7 | 8 | 2 | 1 | 5 | 9 | 14 | |
| 16 | F.C. Juárez | 17 | 4 | 4 | 9 | 14 | 25 | -11 | 16 | LLXL | 8 | 3 | 2 | 3 | 9 | 10 | 9 | 1 | 2 | 6 | 5 | 15 | ||
| 17 | Querétaro | 17 | 3 | 6 | 8 | 11 | 19 | -8 | 15 | LLLW | 8 | 3 | 2 | 3 | 8 | 7 | 9 | 0 | 4 | 5 | 3 | 12 | ||
| 18 | Tijuana | 17 | 3 | 6 | 8 | 16 | 27 | -11 | 15 | WWLO | 9 | 2 | 4 | 3 | 9 | 11 | 8 | 1 | 2 | 5 | 7 | 16 | ||
| 9 | +2 | Nicolás LÓPEZ (Tigres, 2p) |
| Germán BERTERAME (Atlético San Luis, 3p) | ||
| 8 | CAMILO da Silva (Mazatlán, 3p) | |
| 6 | Julio FURCH (Atlas) | |
| Alejandro ZENDEJAS (Necaxa, 2p) | ||
| +3 | Victor DÁVILA (León) | |
| 5 | Diego VALDÉS (Santos Laguna, 1p) | |
| Julian QUIÑONES (Atlas) | ||
| +1 | Cristian TABÓ (Puebla, 2p) | |
| Juan DINENNO (UNAM, 2p) | ||
| 4 | Jonathan DOS SANTOS (Querétaro, 1p) | |
| Duván VERGARA (Monterrey) | ||
| Ángel MENA (León, 2p) | ||
| Fernando GORRIARÁN (Santos Laguna, 3p) | ||
| Santiago GIMÉNEZ (Cruz Azul) | ||
| +1 | Mauro MANOTAS (Tijuana) | |
| ÁLVARO FIDALGO Fernández (América) | ||
| Rubens SAMBUEZA (Toluca, 2p) | ||
| Elías HERNÁNDEZ (León) | ||
| +1 | Ángel ZALDIVAR (Guadalajara, 2p) | |
| +1 | Juan VIGON (Tigres) | |
| +3 | Roberto ALVARADO (Cruz Azul) | |
| Brayan ANGULO (Cruz Azul) | ||
| Rogelio FUNES (Monterrey, 1p) | ||
| Alexis CANELO (Toluca) |
| Friday, 5 November 2021 | ||||||
| 17 | Puebla | 1-0 | Toluca | |||
| 59(p) | Tabó | |||||
| 17 | Mazatlán | 0-1 | Guadalajara | |||
| 86 | Zaldivar | |||||
| Saturday, 6 November 2021 | ||||||
| 17 | América | 0-0 | Monterrey | |||
| 17 | León | 3-0 | Necaxa | |||
| 21 | Dávila | |||||
| 51 | Dávila | |||||
| 71 | Dávila | |||||
| 17 | Tigres | 3-0 | F.C. Juárez | |||
| 5 | López | |||||
| 47 | Vigon | |||||
| 83 | López | |||||
| 17 | Tijuana | 3-2 | Pachuca | |||
| 44(og) | Murillo | 23 | González | |||
| 56 | Manotas | 53 | De La Rosa | |||
| 82(og) | Moreno | |||||
| Sunday, 7 November 2021 | ||||||
| 17 | UNAM | 4-3 | Cruz Azul | |||
| 5 | Ortiz | 11 | Alvarado | |||
| 45 | Álvarez | 20 | Alvarado | |||
| 61 | Diogo | 43 | Alvarado | |||
| 83 | Diogo | |||||
| 17 | Santos Laguna | 0-0 | Atlético San Luis | |||
| Liguilla | ||||||
| Saturday, 20 November 2021 | ||||||
| qp6-5 | Puebla | 2-2 | Guadalajara | p6-5 | ||
| 20(p) | Tabó | 6 | Brizuela | |||
| 89 | Lucas Maia | 62 | Mayorga | |||
| q | Santos Laguna | 2-0 | Atlético San Luis | |||
| 65 | Preciado | |||||
| 85(p) | Jeraldino | |||||
| Sunday, 21 November 2021 | ||||||
| q | Cruz Azul | 1-4 | Monterrey | |||
| 31(p) | Yotún | 10(p) | Funes | |||
| 26 | Meza | |||||
| 58 | Funes | |||||
| 84 | Janssen | |||||
| q | Toluca | 1-2 | UNAM | |||
| 61(p) | Ortega | 15 | López | |||
| 49 | Dinenno | |||||
| Wednesday, 24 November 2021 | ||||||
| qfl1 | UNAM | 0-0 | América | |||
| qfl1 | Monterrey | 0-0 | Atlas | |||
| Thursday, 25 November 2021 | ||||||
| qfl1 | Puebla | 2-1 | León | |||
| 29 | Parra | 28 | Barreiro | |||
| 78 | Araujo | |||||
| qfl1 | Santos Laguna | 2-1 | Tigres | |||
| 4 | Valdés | 73 | Gignac | |||
| 11 | Aguirre | |||||
| Saturday, 27 November 2021 | ||||||
| qfl2 | América | 1-3 | UNAM | 1-3 | ||
| 10(p) | Aguilera | 28 | Corozo | |||
| 41 | Corozo | |||||
| 81 | Higor Meritão | |||||
| qfl2 | Atlas | 1-1 | Monterrey | 1-1 | ||
| 17(p) | Furch | 73 | González | |||
| Sunday, 28 November 2021 | ||||||
| qfl2 | León | 2-0 | Puebla | 3-2 | ||
| 25 | Mena | |||||
| 79(p) | Mena | |||||
| qfl2 | Tigres | 1-0 | Santos Laguna | 2-2 | ||
| 81 | Salcedo | |||||
| Wednesday, 1 December 2021 | ||||||
| sfl1 | Tigres | 2-1 | León | |||
| 89 | Thauvin | 56 | Meneses | |||
| 90 | González | |||||
| Thursday, 2 December 2021 | ||||||
| sfl1 | UNAM | 0-1 | Atlas | |||
| 42 | Furch | |||||
| Saturday, 4 December 2021 | ||||||
| sfl2 | León | 2-1 | Tigres | 3-3 | ||
| 7 | Mena | 15 | Reyes | |||
| 84 | Mena | |||||
| Sunday, 5 December 2021 | ||||||
| sfl2 | Atlas | 0-1 | UNAM | 1-1 | ||
| 75 | Dinenno | |||||
| Thursday, 9 December 2021 | ||||||
| fl1 | León | 3-2 | Atlas | |||
| 7 | Mena | 10 | Reyes | |||
| 36 | Dávila | 64 | Furch | |||
| 85(p) | Mena | |||||
| Sunday, 12 December 2021 | ||||||
| fl2 | Atlas | 1-0 | León | 3-3, aet, p4-3 | ||
| 54 | Rocha | |||||