| Tuesday, 4 February 2025 |
| r1l1 |  Real Hope | 0-2 | Cruz Azul |
|
| Wednesday, 5 February 2025 |
| r1l1 |  Real Estelí | 1-0 | Tigres |
|
| r1l1 |  Forge | 0-2 | Monterrey |
|
| Thursday, 6 February 2025 |
| r1l1 |  Cibao | 1-1 | Guadalajara |
|
| r1l1 | Cavalry | 2-1 | UNAM |
|
| Tuesday, 11 February 2025 |
| r1l2 | Cruz Azul | 5-0 | Real Hope | 7-0 |
| r1l2 | Monterrey | 3-0 | Forge | 5-0 |
| Wednesday, 12 February 2025 |
| r1l2 | Guadalajara | 3-0 | Cibao | 4-1 |
| r1l2 | Tigres | 3-0 | Real Estelí | 3-1 |
| Thursday, 13 February 2025 |
| r1l2 | UNAM | 2-0 | Cavalry | 3-2 |
| Tuesday, 18 February 2025 |
| r1l1 |  Colorado Rapids | 2-1 | Los Angeles |
|
| Wednesday, 19 February 2025 |
| r1l1 | Sporting Kansas City | 0-1 | Inter Miami |
|
| r1l1 |  Herediano | 0-0 | Real Salt Lake |
|
| r1l1 |  Antigua | 1-3 | Seattle Sounders |
|
| Thursday, 20 February 2025 |
| r1l1 | Saprissa | 2-1 | Vancouver Whitecaps |
|
| r1l1 |  Motagua | 1-4 | FC Cincinnati |
|
| Tuesday, 25 February 2025 |
| r1l1 | Los Angeles | 1-0 | Colorado Rapids |
|
| r1l2 | Inter Miami | 3-1 | Sporting Kansas City | 4-1 |
| Wednesday, 26 February 2025 |
| r1l2 | Real Salt Lake | 1-2 | Herediano | 1-2 |
| r1l2 | FC Cincinnati | 1-1 | Motagua | 5-2 |
| Thursday, 27 February 2025 |
| r1l2 | Vancouver Whitecaps | 2-0 | Saprissa | 3-2 |
| r1l2 | Seattle Sounders | 3-1 | Antigua | 6-2 |
