| ROUND | R1 | R2 | QF | |||
| l1 | l2 | l1 | l2 | l1 | l2 | |
| Season archive |
| Tuesday, 4 March 2025 | ||||||
| r2l1 |  UNAM | 2-0 | Alajuelense | |||
| r2l1 |  Los Angeles | 3-0 | Columbus Crew | |||
| r2l1 | FC Cincinnati | 1-1 | Tigres | |||
| Wednesday, 5 March 2025 | ||||||
| r2l1 | Guadalajara | 1-0 | América | |||
| r2l1 | Vancouver Whitecaps | 1-1 | Monterrey | |||
| r2l1 | Herediano | 1-0 | LA Galaxy | |||
| r2l1 | Seattle Sounders | 0-0 | Cruz Azul | |||
| Thursday, 6 March 2025 | ||||||
| r2l1 | Inter Miami | 2-0 | Cavalier | |||
| Tuesday, 11 March 2025 | ||||||
| r2l2 | Cruz Azul | 4-1 | Seattle Sounders | 4-1 | ||
| r2l2 | Columbus Crew | 2-1 | Los Angeles | 2-4 | ||
| r2l2 | Tigres | 3-1 | FC Cincinnati | 4-2 | ||
| Wednesday, 12 March 2025 | ||||||
| r2l2 | América | 4-0 | Guadalajara | 4-1 | ||
| r2l2 | LA Galaxy | 4-1 | Herediano | 4-2 | ||
| r2l2 | Monterrey | 2-2 | Vancouver Whitecaps | 3-3 | ||
| Thursday, 13 March 2025 | ||||||
| r2l2 | Alajuelense | 1-1 | UNAM | 1-3 | ||
| r2l2 | Cavalier | 0-2 | Inter Miami | 0-4 | ||
| 4 | +1 | Ángel SEPÚLVEDA (Cruz Azul) |
| 3 | +1 | Lionel MESSI (Inter Miami) |
| +1 | Brian WHITE (Vancouver Whitecaps) | |
| +1 | Pavel BUCHA (FC Cincinnati) | |
| +3 | Denis BOUANGA (Los Angeles) | |
| Pedro DE LA VEGA (Seattle Sounders) | ||
| +2 | Luis SUÁREZ (Inter Miami) | |
| 2 | Kévin DENKEY (FC Cincinnati) | |
| Paul ARRIOLA (Seattle Sounders) | ||
| Djordje MIHAILOVIC (Colorado Rapids) | ||
| Jordi CORTIZO (Monterrey) | ||
| Gabriel FERNÁNDEZ (Cruz Azul) | ||
| Germán BERTERAME (Monterrey) | ||
| +1 | Elías AGUILAR (Herediano) | |
| Guillermo MARTINEZ (UNAM) | ||
| +2 | Nicolás IBAÑEZ (Tigres) | |
| +1 | Tadeo ALLENDE (Inter Miami) | |
| +2 | Juan BRUNETTA (Tigres) | |
| Rodrigo AUZMENDI (Motagua) | ||
| +1 | EVANDER da Silva (FC Cincinnati) |
