| ROUND | R1 | R2 | QF | |||
| l1 | l2 | l1 | l2 | l1 | l2 | |
| Season archive |
| Tuesday, 4 February 2025 | |||||
| r1l1 |  Real Hope | 0-2 | Cruz Azul | ||
| 38 | Sepúlveda | ||||
| 84(og) | |||||
| Wednesday, 5 February 2025 | |||||
| r1l1 |  Real Estelí | 1-0 | Tigres | ||
| 83 | Grahl | ||||
| r1l1 |  Forge | 0-2 | Monterrey | ||
| 53 | Deossa | ||||
| 66 | Cortizo | ||||
| Thursday, 6 February 2025 | |||||
| r1l1 |  Cibao | 1-1 | Guadalajara | ||
| 1 | Díaz | 90+10 | Rey | ||
| r1l1 | Cavalry | 2-1 | UNAM | ||
| 57 | Trafford | 44 | López | ||
| 80 | Warschewski | ||||
| Tuesday, 18 February 2025 | |||||
| r1l1 |  Colorado Rapids | 2-1 | Los Angeles | ||
| 48(p) | Mihailovic | 87 | Long | ||
| 80 | Mihailovic | ||||
| Wednesday, 19 February 2025 | |||||
| r1l1 | Sporting Kansas City | 0-1 | Inter Miami | ||
| 56 | Messi | ||||
| r1l1 |  Herediano | 0-0 | Real Salt Lake | ||
| r1l1 |  Antigua | 1-3 | Seattle Sounders | ||
| 24 | Santis | 3 | Arriola | ||
| 61 | De La Vega | ||||
| 90+5 | Rusnák | ||||
| Thursday, 20 February 2025 | |||||
| r1l1 | Saprissa | 2-1 | Vancouver Whitecaps | ||
| 51 | Torres | 21 | Gauld | ||
| 90+5 | Rodríguez | ||||
| r1l1 |  Motagua | 1-4 | FC Cincinnati | ||
| 41 | Auzmendi | 28 | Bucha | ||
| 49 | Denkey | ||||
| 78 | Bucha | ||||
| 87 | Evander | ||||
| Tuesday, 25 February 2025 | |||||
| r1l1 | Los Angeles | 1-0 | Colorado Rapids | ||
| 49 | Delgado | ||||
| 2 | +2 | Djordje MIHAILOVIC (Colorado Rapids) |
| +2 | Pavel BUCHA (FC Cincinnati) | |
| 1 | +1 | Kévin DENKEY (FC Cincinnati) |
| +1 | Aaron LONG (Los Angeles) | |
| +1 | Ariel RODRÍGUEZ (Saprissa) | |
| +1 | Marco DELGADO (Los Angeles) | |
| +1 | Paul ARRIOLA (Seattle Sounders) | |
| +1 | Jordi CORTIZO (Monterrey) | |
| +1 | Santiago LÓPEZ (UNAM) | |
| +1 | Lionel MESSI (Inter Miami) | |
| +1 | Mariano TORRES (Saprissa) | |
| +1 | Tobias WARSCHEWSKI (Cavalry) | |
| +1 | Juan DÍAZ (Cibao) | |
| +1 | Oscar SANTIS (Antigua) | |
| +1 | Francisco GRAHL (Real Estelí) | |
| +1 | Luis REY (Guadalajara) | |
| +1 | Ángel SEPÚLVEDA (Cruz Azul) | |
| +1 | Pedro DE LA VEGA (Seattle Sounders) | |
| +1 | Nelson DEOSSA (Monterrey) | |
| +1 | Rodrigo AUZMENDI (Motagua) | |
| +1 | Charlie TRAFFORD (Cavalry) | |
| +1 | Albert RUSNÁK (Seattle Sounders) | |
| +1 | Ryan GAULD (Vancouver Whitecaps) | |
| +1 | EVANDER da Silva (FC Cincinnati) |
