Results| Tuesday, 5 February 2019 |
| r1l1 |  Unión La Calera | 0-0 | Chapecoense |
|
| Wednesday, 6 February 2019 |
| r1l1 | Botafogo | 1-0 | Defensa y Justicia |
|
| Thursday, 7 February 2019 |
| r1l1 | Bahia | 0-1 | Liverpool |
|
| r1l1 |  Deportivo Santaní | 1-1 | Once Caldas |
|
| Tuesday, 12 February 2019 |
| r1l1 | River Plate | 0-0 | Santos |
|
| r1l1 |  Macará | 2-1 | Guabirá |
|
| Thursday, 14 February 2019 |
| r1l1 | Corinthians | 1-1 | Racing Club |
|
| r1l1 | Royal Pari | 2-1 | Monagas |
|
| Tuesday, 19 February 2019 |
| r1l2 | Chapecoense | 1-1 | Unión La Calera | 1-1 |
| Wednesday, 20 February 2019 |
| r1l2 | Defensa y Justicia | 0-3 | Botafogo | 0-4 |
| Thursday, 21 February 2019 |
| r1l2 | Once Caldas | 0-2 | Deportivo Santaní | 1-3 |
| r1l2 | Liverpool | 0-0 | Bahia | 1-0 |
| Tuesday, 26 February 2019 |
| r1l1 | Fluminense | 0-0 | Antofagasta |
|
| r1l2 | Santos | 1-1 | River Plate | 1-1 |
| Wednesday, 27 February 2019 |
| r1l2 | Racing Club | 1-1 | Corinthians | 2-2, p4-5 |
| r1l2 | Monagas | 2-1 | Royal Pari | 3-3, p2-4 |
| Thursday, 28 February 2019 |
| r1l2 | Guabirá | 0-3 | Macará | 1-5 |
| Tuesday, 19 March 2019 |
| r1l1 | Unión Española | 1-1 | Mushuc Runa |
|
| r1l1 |  Deportivo Municipal | 0-3 | Colón |
|
| r1l1 | Nacional Potosí | 0-1 | Zulia* |
|
| Wednesday, 20 March 2019 |
| r1l1 | Unión | 2-0 | Independiente |
|
| r1l1 | Independiente CG | 0-0 | La Equidad |
|
| Thursday, 21 March 2019 |
| r1l1 | Wanderers | 2-0 | Sport Huancayo |
|
| r1l1 | Rionegro | 1-1 | Oriente Petrolero |
|
| r1l2 | Antofagasta | 1-2 | Fluminense | 1-2 |
| Tuesday, 2 April 2019 |
| r1l1 | Mineros | 1-0 | Sol de América |
|
| r1l1 | Universidad Católica | 0-1 | Colo Colo |
|
| Wednesday, 3 April 2019 |
| r1l1 | Independiente | 4-1 | Binacional |
|
| r1l1 | UTC | 1-1 | Cerro |
|
| Thursday, 4 April 2019 |
| r1l1 | Argentinos Juniors | 2-0 | Estudiantes |
|
| r1l1 | Cali | 1-0 | Guaraní |
|
| Tuesday, 16 April 2019 |
| r1l2 | Colón | 2-0 | Deportivo Municipal | 5-0 |
| r1l2 | La Equidad | 0-0 | Independiente CG | 0-0, p4-3 |
| r1l2 | Zulia* | 0-1 | Nacional Potosí | 1-1, p2-0 |
| Wednesday, 17 April 2019 |
| r1l2 | Oriente Petrolero | 1-1 | Rionegro | 2-2, p0-3 |
| r1l2 | Independiente | 2-0 | Unión | 2-2, p4-2 |
| Thursday, 18 April 2019 |
| r1l2 | Sport Huancayo | 1-1 | Wanderers | 1-3 |
| r1l2 | Mushuc Runa | 1-1 | Unión Española | 2-2, p5-6 |
| Tuesday, 30 April 2019 |
| r1l2 | Colo Colo | 0-1 | Universidad Católica | 1-1, p0-3 |
| r1l2 | Cerro | 3-1 | UTC | 4-2 |
| Wednesday, 1 May 2019 |
| r1l2 | Sol de América | 1-0 | Mineros | 1-1, p4-3 |
| r1l2 | Binacional | 1-2 | Independiente | 2-6 |
| Thursday, 2 May 2019 |
| r1l2 | Guaraní | 1-0 | Cali | 1-1, p1-4 |
| Wednesday, 8 May 2019 |
| r1l2 | Estudiantes | 1-0 | Argentinos Juniors | 1-2 |
