| ROUND | C | P | Q1 | Q2 | Q3 | Q4 | R1 | R2 | QF | SF | F | |||||||||||||
| sf | f | l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | r1 | r2 | r3 | r4 | r5 | r6 | l1 | l2 | l1 | l2 | l1 | l2 | |||
| Season archive |
| Tuesday, 3 August 2021 | ||||||
| q3l1 |  PSV | 3-0 | FC Midtjylland | |||
| q3l1 |  Olympiakos | 1-1 | Ludogorets | |||
| q3l1 |  Malmö FF | 2-1 | Rangers | |||
| q3l1 |  Sparta Praha | 0-2 | Monaco | |||
| q3l1 |  Crvena Zvezda | 1-1 | Sheriff | |||
| q3l1 |  Racing Genk | 1-2 | Shakhtar | |||
| q3l1 |  CFR Cluj | 1-1 | Young Boys | |||
| Wednesday, 4 August 2021 | ||||||
| q3l1 |  Spartak | 0-2 | Benfica | |||
| q3l1 |  Ferencváros | 2-0 | Slavia Praha | |||
| q3l1 |  Dinamo Zagreb | 1-1 | Legia Warszawa | |||
| Tuesday, 10 August 2021 | ||||||
| q3l2 | Benfica | 2-0 | Spartak | 4-0 | ||
| q3l2 | Monaco | 3-1 | Sparta Praha | 5-1 | ||
| q3l2 | Legia Warszawa | 0-1 | Dinamo Zagreb | 1-2 | ||
| q3l2 | Young Boys | 3-1 | CFR Cluj | 4-2 | ||
| q3l2 | Rangers | 1-2 | Malmö FF | 2-4 | ||
| q3l2 | Slavia Praha | 1-0 | Ferencváros | 1-2 | ||
| q3l2 | Shakhtar | 2-1 | Racing Genk | 4-2 | ||
| q3l2 | Sheriff | 1-0 | Crvena Zvezda | 2-1 | ||
| q3l2 | FC Midtjylland | 0-1 | PSV | 0-4 | ||
| q3l2 | Ludogorets | 2-2 | Olympiakos | 3-3, aet, p4-1 | ||
