| ROUND | C | P | Q1 | Q2 | Q3 | Q4 | R1 | R2 | QF | SF | F | |||||||||||||
| sf | f | l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | r1 | r2 | r3 | r4 | r5 | r6 | l1 | l2 | l1 | l2 | l1 | l2 | |||
| Season archive |
| Tuesday, 17 August 2021 | ||||||
| q4l1 |  Monaco | 0-1 | Shakhtar | |||
| q4l1 |  FC Salzburg | 2-1 | Brøndby | |||
| q4l1 |  Sheriff | 3-0 | Dinamo Zagreb | |||
| Wednesday, 18 August 2021 | ||||||
| q4l1 |  Benfica | 2-1 | PSV | |||
| q4l1 |  Young Boys | 3-2 | Ferencváros | |||
| q4l1 |  Malmö FF | 2-0 | Ludogorets | |||
| Tuesday, 24 August 2021 | ||||||
| q4l2 | PSV | 0-0 | Benfica | 1-2 | ||
| q4l2 | Ferencváros | 2-3 | Young Boys | 4-6 | ||
| q4l2 | Ludogorets | 2-1 | Malmö FF | 2-3 | ||
| Wednesday, 25 August 2021 | ||||||
| q4l2 | Brøndby | 1-2 | FC Salzburg | 2-4 | ||
| q4l2 | Dinamo Zagreb | 0-0 | Sheriff | 0-3 | ||
| q4l2 | Shakhtar | 2-2 | Monaco | 3-2, aet | ||
