| ROUND | Q1 | Q2 | Q3 | R1 | QF | |||||||||
| l1 | l2 | l1 | l2 | l1 | l2 | r1 | r2 | r3 | r4 | r5 | r6 | l1 | l2 | |
| Season archive |
| Tuesday, 9 March 2021 | ||||||
| q2l1 |  Santos | 2-1 | Deportivo Lara | |||
| q2l1 |  Wanderers | 1-0 | Bolívar | |||
| q2l1 |  Unión Española | 1-0 | Independiente | |||
| Wednesday, 10 March 2021 | ||||||
| q2l1 | Grêmio | 6-1 | Ayacucho FC | |||
| q2l1 | Universidad de Chile | 1-1 | San Lorenzo | |||
| q2l1 | Caracas | 1-2 | Junior | |||
| q2l1 | Universidad Católica | 0-1 | Libertad | |||
| Thursday, 11 March 2021 | ||||||
| q2l1 | Guaraní | 0-2 | Nacional | |||
| Tuesday, 16 March 2021 | ||||||
| q2l2 | Bolívar | 5-0 | Wanderers | 5-1 | ||
| q2l2 | Deportivo Lara | 1-1 | Santos | 2-3 | ||
| q2l2 | Ayacucho FC | 1-2 | Grêmio | 2-8 | ||
| q2l2 | Independiente | 6-2 | Unión Española | 6-3 | ||
| Wednesday, 17 March 2021 | ||||||
| q2l2 | San Lorenzo | 2-0 | Universidad de Chile | 3-1 | ||
| q2l2 | Junior | 3-1 | Caracas | 5-2 | ||
| q2l2 | Libertad | 2-2 | Universidad Católica | 3-2 | ||
| Thursday, 18 March 2021 | ||||||
| q2l2 | Nacional | 3-0 | Guaraní | 5-0 | ||
