| ROUND | Q1 | Q2 | Q3 | R1 | R2 | QF | SF | F | |||||||||||
| l1 | l2 | l1 | l2 | l1 | l2 | r1 | r2 | r3 | r4 | r5 | r6 | l1 | l2 | l1 | l2 | l1 | l2 | ||
| Season archive |
| Tuesday, 9 March 2021 | |||||
| q2l1 |  Santos | 2-1 | Deportivo Lara | ||
| 50 | Vinicius Balieiro | 52 | Anzola | ||
| 70 | Kaiky | ||||
| q2l1 |  Wanderers | 1-0 | Bolívar | ||
| 55 | Rolón | ||||
| q2l1 |  Unión Española | 1-0 | Independiente | ||
| 56(og) | Caicedo | ||||
| Wednesday, 10 March 2021 | |||||
| q2l1 | Grêmio | 6-1 | Ayacucho FC | ||
| 4 | David | 73 | Quina | ||
| 28 | Ferreira | ||||
| 33(p) | Diego Souza | ||||
| 41 | Diego Souza | ||||
| 79 | Da Silva | ||||
| 86 | Diego Souza | ||||
| q2l1 | Universidad de Chile | 1-1 | San Lorenzo | ||
| 76 | Henríquez | 78 | Di Santo | ||
| q2l1 | Caracas | 1-2 | Junior | ||
| 35 | Akinyoola | 69 | Borja | ||
| 90 | Ditta | ||||
| q2l1 | Universidad Católica | 0-1 | Libertad | ||
| 38 | Bogarín | ||||
| Thursday, 11 March 2021 | |||||
| q2l1 | Guaraní | 0-2 | Nacional | ||
| 22 | Barrera | ||||
| 90 | Rovira | ||||
