| ROUND | Q1 | Q2 | Q3 | R1 | QF | |||||||||
| l1 | l2 | l1 | l2 | l1 | l2 | r1 | r2 | r3 | r4 | r5 | r6 | l1 | l2 | |
| Season archive |
| Tuesday, 6 April 2021 | ||||||
| q3l1 |  San Lorenzo | 1-3 | Santos | |||
| Wednesday, 7 April 2021 | ||||||
| q3l1 |  Libertad | 1-0 | Nacional | |||
| Thursday, 8 April 2021 | ||||||
| q3l1 |  Bolívar | 2-1 | Junior | |||
| Friday, 9 April 2021 | ||||||
| q3l1 |  Independiente | 2-1 | Grêmio | |||
| Tuesday, 13 April 2021 | ||||||
| q3l2 | Santos | 2-2 | San Lorenzo | 5-3 | ||
| Wednesday, 14 April 2021 | ||||||
| q3l2 | Nacional | 4-1 | Libertad | 4-2 | ||
| q3l2 | Grêmio | 1-2 | Independiente | 2-4 | ||
| Thursday, 15 April 2021 | ||||||
| q3l2 | Junior | 3-0 | Bolívar | 4-2 | ||
