| ROUND | Q1 | Q2 | Q3 | Q4 | R1 | R2 | R3 | QF | SF | F | |||||||||||||
| l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | r1 | r2 | r3 | r4 | r5 | r6 | l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | ||
| Season archive |
| Group A | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | 1 | LASK | 5 | 4 | 1 | 0 | 9 | 1 | +8 | 13 | WWWX | |
| 2 | 1 | Maccabi Tel Aviv | 5 | 3 | 1 | 1 | 13 | 3 | +10 | 10 | LWWX | |
| 3 | HJK | 5 | 2 | 0 | 3 | 5 | 12 | -7 | 6 | WLLW | ||
| 4 | Alashkert | 5 | 0 | 0 | 5 | 3 | 14 | -11 | 0 | LLLL | ||
| Group B | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | AA Gent | 5 | 3 | 1 | 1 | 5 | 2 | +3 | 10 | LXWW | ||
| 2 | Partizan | 5 | 2 | 1 | 2 | 5 | 3 | +2 | 7 | LXLW | ||
| 3 | Flora | 5 | 1 | 2 | 2 | 5 | 7 | -2 | 5 | WXXL | ||
| 4 | Anorthosis | 5 | 1 | 2 | 2 | 5 | 8 | -3 | 5 | WXXL | ||
| Thursday, 25 November 2021 | |||||
| 5 |  Flora | 1-0 | Partizan | ||
| 44 | Miller | ||||
| 5 |  Anorthosis | 1-0 | AA Gent | ||
| 27 | Christodoulopoulos | ||||
| Group C | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Bodø/Glimt | 5 | 3 | 2 | 0 | 13 | 4 | +9 | 11 | WXWO | ||
| 2 | Roma | 5 | 3 | 1 | 1 | 15 | 9 | +6 | 10 | WXLW | ||
| 3 | Zorya | 5 | 2 | 0 | 3 | 4 | 10 | -6 | 6 | LWWL | ||
| 4 | CSKA | 5 | 0 | 1 | 4 | 1 | 10 | -9 | 1 | LLLO | ||
| Thursday, 25 November 2021 | |||||
| 5 |  Roma | 4-0 | Zorya | ||
| 15 | Pérez | ||||
| 33 | Zaniolo | ||||
| 46 | Abraham | ||||
| 75 | Abraham | ||||
| 5 |  Bodø/Glimt | 2-0 | CSKA | ||
| 25 | Fet | ||||
| 85 | Botheim | ||||
| Group D | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | AZ | 5 | 3 | 2 | 0 | 7 | 3 | +4 | 11 | XWWW | ||
| 2 | 1 | Randers | 5 | 1 | 4 | 0 | 9 | 8 | +1 | 7 | WXXX | |
| 3 | 1 | Jablonec | 5 | 1 | 3 | 1 | 6 | 6 | +0 | 6 | XXXL | |
| 4 | CFR Cluj | 5 | 0 | 1 | 4 | 2 | 7 | -5 | 1 | LLLX | ||
| Thursday, 25 November 2021 | |||||
| 5 |  Jablonec | 1-1 | AZ | ||
| 7 | Kratochvil | 44 | Evjen | ||
| 5 |  Randers | 2-1 | CFR Cluj | ||
| 68 | Kamara | 72 | Deac | ||
| 76 | Piesinger | ||||
| Group E | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Feyenoord | 5 | 3 | 2 | 0 | 9 | 5 | +4 | 11 | XWWW | ||
| 2 | Slavia Praha | 5 | 2 | 1 | 2 | 7 | 6 | +1 | 7 | XWLL | ||
| 3 | 1 | 1.FC Union Berlin | 5 | 2 | 0 | 3 | 7 | 8 | -1 | 6 | WLLW | |
| 4 | 1 | Maccabi Haifa | 5 | 1 | 1 | 3 | 1 | 5 | -4 | 4 | LLWL | |
| Thursday, 25 November 2021 | |||||
| 5 | Slavia Praha | 2-2 | Feyenoord | ||
| 12 | Olayinka | 31 | Dessers | ||
| 66 | Kuchta | 90 | Dessers | ||
| 5 |  Maccabi Haifa | 0-1 | 1.FC Union Berlin | ||
| 66 | Ryerson | ||||
| Group F | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | FC København | 5 | 4 | 0 | 1 | 13 | 5 | +8 | 12 | WWLW | ||
| 2 | Slovan Bratislava | 5 | 2 | 2 | 1 | 8 | 5 | +3 | 8 | OWWX | ||
| 3 | PAOK | 5 | 2 | 2 | 1 | 6 | 4 | +2 | 8 | OLWX | ||
| 4 | Lincoln Red Imps | 5 | 0 | 0 | 5 | 2 | 15 | -13 | 0 | LLLL | ||
| Thursday, 25 November 2021 | |||||
| 5 |  Slovan Bratislava | 0-0 | PAOK | ||
| 5 |  Lincoln Red Imps | 0-4 | FC København | ||
| 5 | Jóhannesson | ||||
| 7 | Lerager | ||||
| 63 | Bøving | ||||
| 73 | Højlund | ||||
| Group G | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Rennes | 5 | 3 | 2 | 0 | 10 | 7 | +3 | 11 | XWWW | ||
| 2 | Tottenham Hotspur | 5 | 2 | 1 | 2 | 11 | 8 | +3 | 7 | LWLW | ||
| 3 | Vitesse | 5 | 2 | 1 | 2 | 9 | 8 | +1 | 7 | XLWL | ||
| 4 | Mura | 5 | 1 | 0 | 4 | 4 | 11 | -7 | 3 | WLLL | ||
| Thursday, 25 November 2021 | |||||
| 5 |  Rennes | 3-3 | Vitesse | ||
| 9 | Laborde | 43 | Huisman | ||
| 39 | Laborde | 75 | Buitink | ||
| 69 | Laborde | 90 | Openda | ||
| 5 |  Mura | 2-1 | Tottenham Hotspur | ||
| 11 | Horvat | 72 | Kane | ||
| 90 | Maroša | ||||
| Group H | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | 1 | FC Basel | 5 | 3 | 2 | 0 | 11 | 6 | +5 | 11 | WXWW | |
| 2 | 1 | Qarabag | 5 | 3 | 2 | 0 | 10 | 5 | +5 | 11 | XWWW | |
| 3 | Omonia | 5 | 0 | 3 | 2 | 5 | 10 | -5 | 3 | XXLL | ||
| 4 | Kairat | 5 | 0 | 1 | 4 | 6 | 11 | -5 | 1 | LLLL | ||
| Thursday, 25 November 2021 | |||||
| 5 |  Qarabag | 2-2 | Omonia | ||
| 49(og) | Psaltis | 43(p) | Ďuriš | ||
| 88 | Patrick Andrade | 90 | Jordi Gómez | ||
| 5 |  Kairat | 2-3 | FC Basel | ||
| 23 | Vágner Love | 45(p) | Arthur | ||
| 56 | Hovhannisyan | 69 | Zhegrova | ||
| 73 | Kasami | ||||
| 5 | +3 | Gaëtan LABORDE (Rennes) |
| 4 | +1 | Harry KANE (Tottenham Hotspur) |
| Ola SOLBAKKEN (Bodø/Glimt) | ||
| +1 | Eirik BOTHEIM (Bodø/Glimt) | |
| André GREEN (Slovan Bratislava) | ||
| +2 | Tammy ABRAHAM (Roma) | |
| 3 | Stephan EL SHAARAWY (Roma) | |
| Tomáš ČVANČARA (Jablonec) | ||
| José KANTÉ (Kairat) | ||
| Jonas WIND (FC København) | ||
| Rauno SAPPINEN (Flora) | ||
| +2 | Cyriel DESSERS (Feyenoord) | |
| Gabi KANIKOVSKI (Maccabi Tel Aviv) | ||
| +1 | Jan KUCHTA (Slavia Praha) | |
| +1 | ARTHUR Mendonça (FC Basel) |
