| ROUND | Q3 | Q4 | R1 | R2 | R3 | QF | SF | F | |||||||||||
| l1 | l2 | l1 | l2 | r1 | r2 | r3 | r4 | r5 | r6 | l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | ||
| Season archive |
| Tuesday, 3 August 2021 | ||||||
| q3l1 |  Neftçi | 2-2 | HJK | |||
| Thursday, 5 August 2021 | ||||||
| q3l1 |  Omonia | 1-0 | Flora | |||
| q3l1 |  Galatasaray | 1-1 | St.Johnstone | |||
| q3l1 |  SK Rapid Wien | 3-0 | Anorthosis | |||
| q3l1 |  Jablonec | 2-4 | Celtic | |||
| q3l1 |  Mura | 0-0 | Žalgiris | |||
| q3l1 |  Kairat | 0-0 | Alashkert | |||
| q3l1 |  Lincoln Red Imps | 1-3 | Slovan Bratislava | |||
| Tuesday, 10 August 2021 | ||||||
| q3l2 | Slovan Bratislava | 1-1 | Lincoln Red Imps | 4-2 | ||
| q3l2 | Flora | 2-1 | Omonia | 2-2, aet, p4-5 | ||
| Thursday, 12 August 2021 | ||||||
| q3l2 | Celtic | 3-0 | Jablonec | 7-2 | ||
| q3l2 | St.Johnstone | 2-4 | Galatasaray | 3-5 | ||
| q3l2 | HJK | 3-0 | Neftçi | 5-2 | ||
| q3l2 | Anorthosis | 2-1 | SK Rapid Wien | 2-4 | ||
| q3l2 | Žalgiris | 0-1 | Mura | 0-1 | ||
| q3l2 | Alashkert | 3-2 | Kairat | 3-2, aet | ||
