| ROUND | Q3 | Q4 | R1 | R2 | R3 | QF | SF | F | |||||||||||
| l1 | l2 | l1 | l2 | r1 | r2 | r3 | r4 | r5 | r6 | l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | ||
| Season archive |
| Group A | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Lyon | 6 | 5 | 1 | 0 | 16 | 5 | +11 | 16 | XWWW | ||
| 2 | Rangers | 6 | 2 | 2 | 2 | 6 | 5 | +1 | 8 | XWXW | ||
| 3 | Sparta Praha | 6 | 2 | 1 | 3 | 6 | 9 | -3 | 7 | WLLL | ||
| 4 | Brøndby | 6 | 0 | 2 | 4 | 2 | 11 | -9 | 2 | LLXL | ||
| Thursday, 16 September 2021 | |||||
| 1 |  Brøndby | 0-0 | Sparta Praha | ||
| 1 |  Rangers | 0-2 | Lyon | ||
| Thursday, 30 September 2021 | |||||
| 2 | Lyon | 3-0 | Brøndby | ||
| 2 | Sparta Praha | 1-0 | Rangers | ||
| Thursday, 21 October 2021 | |||||
| 3 | Rangers | 2-0 | Brøndby | ||
| 3 | Sparta Praha | 3-4 | Lyon | ||
| Thursday, 4 November 2021 | |||||
| 4 | Brøndby | 1-1 | Rangers | ||
| 4 | Lyon | 3-0 | Sparta Praha | ||
| Thursday, 25 November 2021 | |||||
| 5 | Brøndby | 1-3 | Lyon | ||
| 5 | Rangers | 2-0 | Sparta Praha | ||
| Thursday, 9 December 2021 | |||||
| 6 | Lyon | 1-1 | Rangers | ||
| 6 | Sparta Praha | 2-0 | Brøndby | ||
| Group B | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Monaco | 6 | 3 | 3 | 0 | 7 | 4 | +3 | 12 | XWOW | ||
| 2 | Real Sociedad | 6 | 2 | 3 | 1 | 9 | 6 | +3 | 9 | WLXW | ||
| 3 | PSV | 6 | 2 | 2 | 2 | 9 | 8 | +1 | 8 | LWOL | ||
| 4 | SK Sturm Graz | 6 | 0 | 2 | 4 | 3 | 10 | -7 | 2 | XLXL | ||
| Thursday, 16 September 2021 | |||||
| 1 | Monaco | 1-0 | SK Sturm Graz | ||
| 1 |  PSV | 2-2 | Real Sociedad | ||
| Thursday, 30 September 2021 | |||||
| 2 | Real Sociedad | 1-1 | Monaco | ||
| 2 | SK Sturm Graz | 1-4 | PSV | ||
| Thursday, 21 October 2021 | |||||
| 3 | PSV | 1-2 | Monaco | ||
| 3 | SK Sturm Graz | 0-1 | Real Sociedad | ||
| Thursday, 4 November 2021 | |||||
| 4 | Monaco | 0-0 | PSV | ||
| 4 | Real Sociedad | 1-1 | SK Sturm Graz | ||
| Thursday, 25 November 2021 | |||||
| 5 | Monaco | 2-1 | Real Sociedad | ||
| 5 | PSV | 2-0 | SK Sturm Graz | ||
| Thursday, 9 December 2021 | |||||
| 6 | Real Sociedad | 3-0 | PSV | ||
| 6 | SK Sturm Graz | 1-1 | Monaco | ||
| Group C | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Spartak | 6 | 3 | 1 | 2 | 10 | 9 | +1 | 10 | WWXL | ||
| 2 | Napoli | 6 | 3 | 1 | 2 | 15 | 10 | +5 | 10 | WLWW | ||
| 3 | Leicester City | 6 | 2 | 2 | 2 | 12 | 11 | +1 | 8 | LWXW | ||
| 4 | Legia Warszawa | 6 | 2 | 0 | 4 | 4 | 11 | -7 | 6 | LLLL | ||
| Wednesday, 15 September 2021 | |||||
| 1 |  Spartak | 0-1 | Legia Warszawa | ||
| Thursday, 16 September 2021 | |||||
| 1 |  Leicester City | 2-2 | Napoli | ||
| Thursday, 30 September 2021 | |||||
| 2 | Napoli | 2-3 | Spartak | ||
| 2 | Legia Warszawa | 1-0 | Leicester City | ||
| Wednesday, 20 October 2021 | |||||
| 3 | Spartak | 3-4 | Leicester City | ||
| Thursday, 21 October 2021 | |||||
| 3 | Napoli | 3-0 | Legia Warszawa | ||
| Thursday, 4 November 2021 | |||||
| 4 | Leicester City | 1-1 | Spartak | ||
| 4 | Legia Warszawa | 1-4 | Napoli | ||
| Wednesday, 24 November 2021 | |||||
| 5 | Spartak | 2-1 | Napoli | ||
| Thursday, 25 November 2021 | |||||
| 5 | Leicester City | 3-1 | Legia Warszawa | ||
| Thursday, 9 December 2021 | |||||
| 6 | Napoli | 3-2 | Leicester City | ||
| 6 | Legia Warszawa | 0-1 | Spartak | ||
| Group D | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Eintracht Frankfurt | 6 | 3 | 3 | 0 | 10 | 6 | +4 | 12 | XXWW | ||
| 2 | Olympiakos | 6 | 3 | 0 | 3 | 8 | 7 | +1 | 9 | LWLL | ||
| 3 | Fenerbahçe | 6 | 1 | 3 | 2 | 7 | 8 | -1 | 6 | XLWX | ||
| 4 | Antwerp | 6 | 1 | 2 | 3 | 6 | 10 | -4 | 5 | WXLX | ||
| Thursday, 16 September 2021 | |||||
| 1 |  Eintracht Frankfurt | 1-1 | Fenerbahçe | ||
| 1 |  Olympiakos | 2-1 | Antwerp | ||
| Thursday, 30 September 2021 | |||||
| 2 | Antwerp | 0-1 | Eintracht Frankfurt | ||
| 2 | Fenerbahçe | 0-3 | Olympiakos | ||
| Thursday, 21 October 2021 | |||||
| 3 | Fenerbahçe | 2-2 | Antwerp | ||
| 3 | Eintracht Frankfurt | 3-1 | Olympiakos | ||
| Thursday, 4 November 2021 | |||||
| 4 | Antwerp | 0-3 | Fenerbahçe | ||
| 4 | Olympiakos | 1-2 | Eintracht Frankfurt | ||
| Thursday, 25 November 2021 | |||||
| 5 | Eintracht Frankfurt | 2-2 | Antwerp | ||
| 5 | Olympiakos | 1-0 | Fenerbahçe | ||
| Thursday, 9 December 2021 | |||||
| 6 | Antwerp | 1-0 | Olympiakos | ||
| 6 | Fenerbahçe | 1-1 | Eintracht Frankfurt | ||
| Group E | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Galatasaray | 6 | 3 | 3 | 0 | 7 | 3 | +4 | 12 | OWXW | ||
| 2 | Lazio | 6 | 2 | 3 | 1 | 7 | 3 | +4 | 9 | OWXO | ||
| 3 | Marseille | 6 | 1 | 4 | 1 | 6 | 7 | -1 | 7 | WLXO | ||
| 4 | Lokomotiv | 6 | 0 | 2 | 4 | 2 | 9 | -7 | 2 | LLXL | ||
| Thursday, 16 September 2021 | |||||
| 1 | Galatasaray | 1-0 | Lazio | ||
| 1 | Lokomotiv | 1-1 | Marseille | ||
| Thursday, 30 September 2021 | |||||
| 2 | Lazio | 2-0 | Lokomotiv | ||
| 2 | Marseille | 0-0 | Galatasaray | ||
| Thursday, 21 October 2021 | |||||
| 3 | Lazio | 0-0 | Marseille | ||
| 3 | Lokomotiv | 0-1 | Galatasaray | ||
| Thursday, 4 November 2021 | |||||
| 4 | Marseille | 2-2 | Lazio | ||
| 4 | Galatasaray | 1-1 | Lokomotiv | ||
| Thursday, 25 November 2021 | |||||
| 5 | Galatasaray | 4-2 | Marseille | ||
| 5 | Lokomotiv | 0-3 | Lazio | ||
| Thursday, 9 December 2021 | |||||
| 6 | Lazio | 0-0 | Galatasaray | ||
| 6 | Marseille | 1-0 | Lokomotiv | ||
| Group F | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Crvena Zvezda | 6 | 3 | 2 | 1 | 6 | 4 | +2 | 11 | XWLX | ||
| 2 | Sporting Braga | 6 | 3 | 1 | 2 | 12 | 9 | +3 | 10 | XLWW | ||
| 3 | FC Midtjylland | 6 | 2 | 3 | 1 | 7 | 7 | +0 | 9 | OWWX | ||
| 4 | Ludogorets | 6 | 0 | 2 | 4 | 3 | 8 | -5 | 2 | OLLL | ||
| Thursday, 16 September 2021 | |||||
| 1 |  Crvena Zvezda | 2-1 | Sporting Braga | ||
| 1 | FC Midtjylland | 1-1 | Ludogorets | ||
| Thursday, 30 September 2021 | |||||
| 2 | Sporting Braga | 3-1 | FC Midtjylland | ||
| 2 | Ludogorets | 0-1 | Crvena Zvezda | ||
| Thursday, 21 October 2021 | |||||
| 3 | FC Midtjylland | 1-1 | Crvena Zvezda | ||
| 3 | Ludogorets | 0-1 | Sporting Braga | ||
| Thursday, 4 November 2021 | |||||
| 4 | Sporting Braga | 4-2 | Ludogorets | ||
| 4 | Crvena Zvezda | 0-1 | FC Midtjylland | ||
| Thursday, 25 November 2021 | |||||
| 5 | Crvena Zvezda | 1-0 | Ludogorets | ||
| 5 | FC Midtjylland | 3-2 | Sporting Braga | ||
| Thursday, 9 December 2021 | |||||
| 6 | Sporting Braga | 1-1 | Crvena Zvezda | ||
| 6 | Ludogorets | 0-0 | FC Midtjylland | ||
| Group G | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Bayer Leverkusen | 6 | 4 | 1 | 1 | 14 | 5 | +9 | 13 | LWWX | ||
| 2 | Real Betis | 6 | 3 | 1 | 2 | 12 | 12 | +0 | 10 | LWLX | ||
| 3 | Celtic | 6 | 3 | 0 | 3 | 13 | 15 | -2 | 9 | WLWW | ||
| 4 | Ferencváros | 6 | 1 | 0 | 5 | 5 | 12 | -7 | 3 | WLLL | ||
| Thursday, 16 September 2021 | |||||
| 1 | Bayer Leverkusen | 2-1 | Ferencváros | ||
| 1 | Real Betis | 4-3 | Celtic | ||
| Thursday, 30 September 2021 | |||||
| 2 | Celtic | 0-4 | Bayer Leverkusen | ||
| 2 | Ferencváros | 1-3 | Real Betis | ||
| Tuesday, 19 October 2021 | |||||
| 3 | Celtic | 2-0 | Ferencváros | ||
| Thursday, 21 October 2021 | |||||
| 3 | Real Betis | 1-1 | Bayer Leverkusen | ||
| Thursday, 4 November 2021 | |||||
| 4 | Bayer Leverkusen | 4-0 | Real Betis | ||
| 4 | Ferencváros | 2-3 | Celtic | ||
| Thursday, 25 November 2021 | |||||
| 5 | Bayer Leverkusen | 3-2 | Celtic | ||
| 5 | Real Betis | 2-0 | Ferencváros | ||
| Thursday, 9 December 2021 | |||||
| 6 | Celtic | 3-2 | Real Betis | ||
| 6 | Ferencváros | 1-0 | Bayer Leverkusen | ||
| Group H | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | West Ham United | 6 | 4 | 1 | 1 | 11 | 3 | +8 | 13 | LWXW | ||
| 2 | Dinamo Zagreb | 6 | 3 | 1 | 2 | 9 | 6 | +3 | 10 | WXWL | ||
| 3 | SK Rapid Wien | 6 | 2 | 0 | 4 | 4 | 9 | -5 | 6 | WLLW | ||
| 4 | Racing Genk | 6 | 1 | 2 | 3 | 4 | 10 | -6 | 5 | LXXL | ||
| Thursday, 16 September 2021 | |||||
| 1 |  Dinamo Zagreb | 0-2 | West Ham United | ||
| 1 | SK Rapid Wien | 0-1 | Racing Genk | ||
| Thursday, 30 September 2021 | |||||
| 2 | West Ham United | 2-0 | SK Rapid Wien | ||
| 2 | Racing Genk | 0-3 | Dinamo Zagreb | ||
| Thursday, 21 October 2021 | |||||
| 3 | West Ham United | 3-0 | Racing Genk | ||
| 3 | SK Rapid Wien | 2-1 | Dinamo Zagreb | ||
| Thursday, 4 November 2021 | |||||
| 4 | Dinamo Zagreb | 3-1 | SK Rapid Wien | ||
| 4 | Racing Genk | 2-2 | West Ham United | ||
| Thursday, 25 November 2021 | |||||
| 5 | Dinamo Zagreb | 1-1 | Racing Genk | ||
| 5 | SK Rapid Wien | 0-2 | West Ham United | ||
| Thursday, 9 December 2021 | |||||
| 6 | West Ham United | 0-1 | Dinamo Zagreb | ||
| 6 | Racing Genk | 0-1 | SK Rapid Wien | ||
| 6 | +6 | Wenderson GALENO (Sporting Braga, 2p) |
| +6 | Karl TOKO EKAMBI (Lyon) | |
| 5 | +5 | Patson DAKA (Leicester City) |
| 4 | +4 | Elif ELMAS (Napoli) |
| +4 | Aleksandr SOBOLEV (Spartak, 1p) | |
| +4 | Arkadiusz MILIK (Marseille, 1p) | |
| +4 | Victor OSIMHEN (Napoli) | |
| 3 | +3 | Moussa DIABY (Bayer Leverkusen) |
| +3 | Youssef EL ARABI (Olympiakos, 1p) | |
| +3 | Daichi KAMADA (Eintracht Frankfurt) | |
| +3 | Bruno PETKOVIĆ (Dinamo Zagreb, 2p) | |
| +3 | BORJA IGLESIAS Quintas (Real Betis, 1p) | |
| +3 | Saïd BENRAHMA (West Ham United) | |
| +3 | Ricardo HORTA (Sporting Braga) | |
| +3 | Florian WIRTZ (Bayer Leverkusen) | |
| +3 | Ciro IMMOBILE (Lazio, 2p) | |
| +3 | Alexander ISAK (Real Sociedad) | |
| +3 | Islam SLIMANI (Lyon) | |
| +3 | Mbwana SAMATTA (Antwerp) | |
| +3 | Robert ANDRICH (Bayer Leverkusen) |
