| ROUND | Q3 | Q4 | R1 | R2 | R3 | QF | SF | F | |||||||||||
| l1 | l2 | l1 | l2 | r1 | r2 | r3 | r4 | r5 | r6 | l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | ||
| Season archive |
| Group A | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Lyon | 4 | 4 | 0 | 0 | 12 | 3 | +9 | 12 | WWWW | ||
| 2 | 1 | Rangers | 4 | 1 | 1 | 2 | 3 | 4 | -1 | 4 | XWLL | |
| 3 | 1 | Sparta Praha | 4 | 1 | 1 | 2 | 4 | 7 | -3 | 4 | LLWO | |
| 4 | Brøndby | 4 | 0 | 2 | 2 | 1 | 6 | -5 | 2 | XLLO | ||
| Thursday, 4 November 2021 | |||||
| 4 |  Brøndby | 1-1 | Rangers | ||
| 45(og) | Balogun | 77 | Hagi | ||
| 4 |  Lyon | 3-0 | Sparta Praha | ||
| 61 | Slimani | ||||
| 63 | Slimani | ||||
| 90 | Toko Ekambi | ||||
| Group B | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Monaco | 4 | 2 | 2 | 0 | 4 | 2 | +2 | 8 | OWXW | ||
| 2 | Real Sociedad | 4 | 1 | 3 | 0 | 5 | 4 | +1 | 6 | XWXX | ||
| 3 | PSV | 4 | 1 | 2 | 1 | 7 | 5 | +2 | 5 | OLWX | ||
| 4 | SK Sturm Graz | 4 | 0 | 1 | 3 | 2 | 7 | -5 | 1 | XLLL | ||
| Thursday, 4 November 2021 | |||||
| 4 | Monaco | 0-0 | PSV | ||
| 4 |  Real Sociedad | 1-1 | SK Sturm Graz | ||
| 53 | Sørloth | 38 | Jantscher | ||
| Group C | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | 1 | Napoli | 4 | 2 | 1 | 1 | 11 | 6 | +5 | 7 | WWLX | |
| 2 | 1 | Legia Warszawa | 4 | 2 | 0 | 2 | 3 | 7 | -4 | 6 | LLWW | |
| 3 | Leicester City | 4 | 1 | 2 | 1 | 7 | 7 | +0 | 5 | XWLX | ||
| 4 | Spartak | 4 | 1 | 1 | 2 | 7 | 8 | -1 | 4 | XLWL | ||
| Thursday, 4 November 2021 | |||||
| 4 |  Leicester City | 1-1 | Spartak | ||
| 58 | Amartey | 51 | Moses | ||
| 4 |  Legia Warszawa | 1-4 | Napoli | ||
| 10 | Emreli | 51(p) | Zieliński | ||
| 75(p) | Mertens | ||||
| 79 | Lozano | ||||
| 90 | Ounas | ||||
| Group D | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Eintracht Frankfurt | 4 | 3 | 1 | 0 | 7 | 3 | +4 | 10 | WWWX | ||
| 2 | Olympiakos | 4 | 2 | 0 | 2 | 7 | 6 | +1 | 6 | LLWW | ||
| 3 | Fenerbahçe | 4 | 1 | 2 | 1 | 6 | 6 | +0 | 5 | WXLX | ||
| 4 | Antwerp | 4 | 0 | 1 | 3 | 3 | 8 | -5 | 1 | LXLL | ||
| Thursday, 4 November 2021 | |||||
| 4 |  Antwerp | 0-3 | Fenerbahçe | ||
| 8 | Mert Hakan | ||||
| 16 | Meyer | ||||
| 29 | Berisha | ||||
| 4 |  Olympiakos | 1-2 | Eintracht Frankfurt | ||
| 12 | El Arabi | 17 | Kamada | ||
| 90 | Hauge | ||||
| Group E | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Galatasaray | 4 | 2 | 2 | 0 | 3 | 1 | +2 | 8 | XWOW | ||
| 2 | Lazio | 4 | 1 | 2 | 1 | 4 | 3 | +1 | 5 | XOWL | ||
| 3 | Marseille | 4 | 0 | 4 | 0 | 3 | 3 | +0 | 4 | XOOX | ||
| 4 | Lokomotiv | 4 | 0 | 2 | 2 | 2 | 5 | -3 | 2 | XLLX | ||
| Thursday, 4 November 2021 | |||||
| 4 | Marseille | 2-2 | Lazio | ||
| 33(p) | Milik | 45 | Felipe Anderson | ||
| 82 | Payet | 49 | Immobile | ||
| 4 | Galatasaray | 1-1 | Lokomotiv | ||
| 43 | Feghouli | 72 | Kamano | ||
| Group F | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | 1 | Sporting Braga | 4 | 3 | 0 | 1 | 9 | 5 | +4 | 9 | WWWL | |
| 2 | 1 | Crvena Zvezda | 4 | 2 | 1 | 1 | 4 | 3 | +1 | 7 | LXWW | |
| 3 | FC Midtjylland | 4 | 1 | 2 | 1 | 4 | 5 | -1 | 5 | WXLX | ||
| 4 | Ludogorets | 4 | 0 | 1 | 3 | 3 | 7 | -4 | 1 | LLLX | ||
| Thursday, 4 November 2021 | |||||
| 4 |  Sporting Braga | 4-2 | Ludogorets | ||
| 25 | Al-Musrati | 33 | Sotiriou | ||
| 37 | Iuri Medeiros | 79 | Plastun | ||
| 40 | Galeno | ||||
| 73 | Mario | ||||
| 4 |  Crvena Zvezda | 0-1 | FC Midtjylland | ||
| 56(og) | Kanga | ||||
| Group G | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | Bayer Leverkusen | 4 | 3 | 1 | 0 | 11 | 2 | +9 | 10 | WXWW | ||
| 2 | Real Betis | 4 | 2 | 1 | 1 | 8 | 9 | -1 | 7 | LXWW | ||
| 3 | Celtic | 4 | 2 | 0 | 2 | 8 | 10 | -2 | 6 | WWLL | ||
| 4 | Ferencváros | 4 | 0 | 0 | 4 | 4 | 10 | -6 | 0 | LLLL | ||
| Thursday, 4 November 2021 | |||||
| 4 | Bayer Leverkusen | 4-0 | Real Betis | ||
| 42 | Diaby | ||||
| 52 | Diaby | ||||
| 86 | Wirtz | ||||
| 90 | Amiri | ||||
| 4 |  Ferencváros | 2-3 | Celtic | ||
| 11(og) | Juranović | 3 | Furuhashi | ||
| 86 | Uzuni | 23 | Jota | ||
| 60 | Abada | ||||
| Group H | Overall | |||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | ||||
| 1 | West Ham United | 4 | 3 | 1 | 0 | 9 | 2 | +7 | 10 | XWWW | ||
| 2 | Dinamo Zagreb | 4 | 2 | 0 | 2 | 7 | 5 | +2 | 6 | WLWL | ||
| 3 | 1 | Racing Genk | 4 | 1 | 1 | 2 | 3 | 8 | -5 | 4 | XLLW | |
| 4 | 1 | SK Rapid Wien | 4 | 1 | 0 | 3 | 3 | 7 | -4 | 3 | LWLL | |
| Thursday, 4 November 2021 | |||||
| 4 |  Dinamo Zagreb | 3-1 | SK Rapid Wien | ||
| 12 | Petković | 8 | Knasmüllner | ||
| 34 | Andrić | ||||
| 83 | Šutalo | ||||
| 4 | Racing Genk | 2-2 | West Ham United | ||
| 5 | Paintsil | 59 | Benrahma | ||
| 88(og) | Souček | 82 | Benrahma | ||
| 6 | +1 | Karl TOKO EKAMBI (Lyon) |
| 4 | Patson DAKA (Leicester City) | |
| +1 | Wenderson GALENO (Sporting Braga, 1p) | |
| Victor OSIMHEN (Napoli) | ||
| 3 | +1 | Youssef EL ARABI (Olympiakos, 1p) |
| +1 | Bruno PETKOVIĆ (Dinamo Zagreb, 2p) | |
| +2 | Saïd BENRAHMA (West Ham United) | |
| +1 | Florian WIRTZ (Bayer Leverkusen) | |
| 2 | +1 | Myrto UZUNI (Ferencváros) |
| +2 | Moussa DIABY (Bayer Leverkusen) | |
| Giorgos MASOURAS (Olympiakos) | ||
| JUANMI (Real Betis) | ||
| Lukás HARASLÍN (Sparta Praha) | ||
| +1 | Daichi KAMADA (Eintracht Frankfurt) | |
| Enner VALENCIA (Fenerbahçe, 1p) | ||
| Aleksandr SOBOLEV (Spartak) | ||
| BORJA IGLESIAS Quintas (Real Betis, 1p) | ||
| Cody GAKPO (PSV) | ||
| Declan RICE (West Ham United) | ||
| Ricardo HORTA (Sporting Braga) | ||
| +1 | Mahir EMRELI (Legia Warszawa) | |
| Houssem AOUAR (Lyon) | ||
| Alexander ISAK (Real Sociedad) | ||
| Quincy PROMES (Spartak) | ||
| +2 | Islam SLIMANI (Lyon) | |
| +1 | Kyogo FURUHASHI (Celtic) | |
| Mbwana SAMATTA (Antwerp) |
