| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 
| 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 
| Season archive | 
| Games | Goals | H | D | A | ||||
| 238 | 601 | 2.52 | 102 | 42.86% | 75 | 31.51% | 61 | 25.63% | 
| 2021/22 | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Real Madrid | 24 | 16 | 6 | 2 | 48 | 20 | +28 | 54 | OWXW | 12 | 8 | 4 | 0 | 25 | 8 | 12 | 8 | 2 | 2 | 23 | 12 | ||
| 2 | Sevilla | 24 | 14 | 8 | 2 | 36 | 16 | +20 | 50 | WOXX | 12 | 9 | 3 | 0 | 26 | 10 | 12 | 5 | 5 | 2 | 10 | 6 | ||
| 3 | Real Betis | 24 | 13 | 4 | 7 | 45 | 29 | +16 | 43 | WLWW | 12 | 6 | 2 | 4 | 23 | 14 | 12 | 7 | 2 | 3 | 22 | 15 | ||
| 4 | Barcelona | 23 | 10 | 9 | 4 | 38 | 27 | +11 | 39 | XWWX | 11 | 7 | 2 | 2 | 23 | 13 | 12 | 3 | 7 | 2 | 15 | 14 | ||
| 5 | Atlético Madrid | 24 | 11 | 6 | 7 | 42 | 34 | +8 | 39 | LWLW | 12 | 7 | 3 | 2 | 21 | 12 | 12 | 4 | 3 | 5 | 21 | 22 | ||
| 6 | 1 | Real Sociedad | 23 | 10 | 8 | 5 | 24 | 21 | +3 | 38 | WOOW | 12 | 6 | 4 | 2 | 9 | 6 | 11 | 4 | 4 | 3 | 15 | 15 | |
| 7 | 1 | Villarreal | 24 | 9 | 9 | 6 | 38 | 23 | +15 | 36 | OWWL | 13 | 7 | 4 | 2 | 29 | 13 | 11 | 2 | 5 | 4 | 9 | 10 | |
| 8 | Athletic Bilbao | 24 | 8 | 10 | 6 | 25 | 21 | +4 | 34 | LWWO | 11 | 5 | 2 | 4 | 15 | 13 | 13 | 3 | 8 | 2 | 10 | 8 | ||
| 9 | 3 | Osasuna | 24 | 8 | 8 | 8 | 25 | 27 | -2 | 32 | WOWL | 12 | 2 | 6 | 4 | 10 | 16 | 12 | 6 | 2 | 4 | 15 | 11 | |
| 10 | 1 | Celta Vigo | 24 | 8 | 7 | 9 | 28 | 25 | +3 | 31 | OWXW | 12 | 4 | 2 | 6 | 15 | 15 | 12 | 4 | 5 | 3 | 13 | 10 | |
| 11 | 2 | Rayo Vallecano | 23 | 9 | 4 | 10 | 27 | 27 | +0 | 31 | LLLX | 12 | 8 | 2 | 2 | 20 | 8 | 11 | 1 | 2 | 8 | 7 | 19 | |
| 12 | 2 | Valencia | 24 | 7 | 9 | 8 | 36 | 38 | -2 | 30 | LOLX | 12 | 4 | 6 | 2 | 18 | 13 | 12 | 3 | 3 | 6 | 18 | 25 | |
| 13 | Espanyol | 24 | 7 | 7 | 10 | 29 | 34 | -5 | 28 | XLLX | 12 | 6 | 3 | 3 | 18 | 15 | 12 | 1 | 4 | 7 | 11 | 19 | ||
| 14 | Elche | 24 | 6 | 8 | 10 | 26 | 33 | -7 | 26 | LWXW | 11 | 4 | 5 | 2 | 13 | 11 | 13 | 2 | 3 | 8 | 13 | 22 | ||
| 15 | 2 | Mallorca | 23 | 6 | 8 | 9 | 22 | 36 | -14 | 26 | WWLL | 12 | 4 | 6 | 2 | 13 | 11 | 11 | 2 | 2 | 7 | 9 | 25 | |
| 16 | 1 | Getafe | 24 | 6 | 7 | 11 | 23 | 27 | -4 | 25 | LWOW | 12 | 6 | 2 | 4 | 17 | 11 | 12 | 0 | 5 | 7 | 6 | 16 | |
| 17 | 1 | Granada | 24 | 5 | 9 | 10 | 26 | 36 | -10 | 24 | LLLL | 11 | 4 | 3 | 4 | 16 | 17 | 13 | 1 | 6 | 6 | 10 | 19 | |
| 18 | 1 | Alavés | 24 | 5 | 5 | 14 | 19 | 39 | -20 | 20 | WLLL | 13 | 4 | 3 | 6 | 10 | 15 | 11 | 1 | 2 | 8 | 9 | 24 | |
| 19 | 1 | Cádiz | 24 | 3 | 10 | 11 | 20 | 38 | -18 | 19 | OLWX | 12 | 0 | 7 | 5 | 8 | 17 | 12 | 3 | 3 | 6 | 12 | 21 | |
| 20 | Levante | 24 | 2 | 8 | 14 | 24 | 50 | -26 | 14 | WLLL | 12 | 1 | 6 | 5 | 13 | 21 | 12 | 1 | 2 | 9 | 11 | 29 | ||
| 17 | Karim BENZEMA (Real Madrid, 2p) | |
| 13 | +1 | Raúl DE TOMÁS (Espanyol, 4p) | 
| 12 | +1 | JOSELU (Alavés, 5p) | 
| JUANMI (Real Betis) | ||
| VINÍCIUS José JÚNIOR (Real Madrid) | ||
| 11 | +2 | ENES Ünal (Getafe, 2p) | 
| IAGO Aspas (Celta Vigo, 2p) | ||
| 10 | +2 | Ángel CORREA (Atlético Madrid) | 
| 9 | +1 | GONÇALO Manuel GUEDES (Valencia, 1p) | 
| 8 | +1 | MIKEL Oyarzabal (Real Sociedad, 3p) | 
| GERARD Moreno (Villarreal, 1p) | ||
| Luis SUÁREZ (Atlético Madrid, 1p) | ||
| Memphis DEPAY (Barcelona, 3p) | ||
| 7 | PERE MILLA Peña (Elche) | |
| CARLOS SOLER Barragán (Valencia, 5p) | ||
| Lucas BOYÉ (Elche) | ||
| Jorge MOLINA (Granada) | ||
| +1 | RAFA MIR (Sevilla) | |
| SANTI MINA (Celta Vigo) | ||
| BORJA IGLESIAS Quintas (Real Betis, 2p) | ||
| 6 | +2 | Nabil FEKIR (Real Betis) | 
| HUGO DURO Perales (Valencia) | ||
| JOSÉ Luis MORALES (Levante) | ||
| WILLIAN José (Real Betis, 2p) | ||
| Marco ASENSIO (Real Madrid) | ||
| Luis SUÁREZ (Granada) | 
| Friday, 11 February 2022 | |||||
| 24 | Sevilla | 2-0 | Elche | ||
| 70 | Gómez | ||||
| 75 | Rafa Mir | ||||
| Saturday, 12 February 2022 | |||||
| 24 | Atlético Madrid | 4-3 | Getafe | ||
| 19 | Correa | 30 | Mayoral | ||
| 27 | Matheus Cunha | 36(p) | Enes | ||
| 45 | Correa | 42(p) | Enes | ||
| 89 | Mario Hermoso | ||||
| 24 | Rayo Vallecano | 0-3 | Osasuna | ||
| 8 | Moncayola | ||||
| 40 | Rubén | ||||
| 90 | Kike | ||||
| 24 | Villarreal | 0-0 | Real Madrid | ||
| 24 | Cádiz | 0-0 | Celta Vigo | ||
| Sunday, 13 February 2022 | |||||
| 24 | Espanyol | 2-2 | Barcelona | ||
| 40 | Sergi Darder | 2 | Pedri | ||
| 64 | De Tomás | 90 | De Jong | ||
| 24 | Real Sociedad | 2-0 | Granada | ||
| 36(p) | Mikel | ||||
| 74 | Rafinha | ||||
| 24 | Alavés | 2-1 | Valencia | ||
| 14 | Loum | 62(p) | Gonçalo Guedes | ||
| 76(p) | Joselu | ||||
| 24 | Levante | 2-4 | Real Betis | ||
| 43 | Dani Gómez | 14 | Fekir | ||
| 47 | Dani Gómez | 29 | Édgar | ||
| 42 | William Carvalho | ||||
| 49 | Fekir | ||||
| Monday, 14 February 2022 | |||||
| 24 | Mallorca | 3-2 | Athletic Bilbao | ||
| 22(p) | Salva Sevilla | 59 | Raúl García | ||
| 30 | Ángel | 61 | Álex Berenguer | ||
| 88(og) | Simón | ||||
| Wednesday, 16 February 2022 | |||||
| 21 | Atlético Madrid | 0-1 | Levante | ||
| 54 | Melero | ||||