| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 |
| 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 248 | 633 | 2.55 | 106 | 42.74% | 78 | 31.45% | 64 | 25.81% |
| 2021/22 | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Real Madrid | 25 | 17 | 6 | 2 | 51 | 20 | +31 | 57 | WOWX | 13 | 9 | 4 | 0 | 28 | 8 | 12 | 8 | 2 | 2 | 23 | 12 | ||
| 2 | Sevilla | 25 | 14 | 9 | 2 | 37 | 17 | +20 | 51 | XWOX | 12 | 9 | 3 | 0 | 26 | 10 | 13 | 5 | 6 | 2 | 11 | 7 | ||
| 3 | Real Betis | 25 | 14 | 4 | 7 | 47 | 30 | +17 | 46 | WWLW | 13 | 7 | 2 | 4 | 25 | 15 | 12 | 7 | 2 | 3 | 22 | 15 | ||
| 4 | Barcelona | 24 | 11 | 9 | 4 | 42 | 28 | +14 | 42 | WXWW | 11 | 7 | 2 | 2 | 23 | 13 | 13 | 4 | 7 | 2 | 19 | 15 | ||
| 5 | Atlético Madrid | 25 | 12 | 6 | 7 | 45 | 34 | +11 | 42 | WLWL | 12 | 7 | 3 | 2 | 21 | 12 | 13 | 5 | 3 | 5 | 24 | 22 | ||
| 6 | 1 | Villarreal | 25 | 10 | 9 | 6 | 42 | 24 | +18 | 39 | WOWW | 13 | 7 | 4 | 2 | 29 | 13 | 12 | 3 | 5 | 4 | 13 | 11 | |
| 7 | 1 | Real Sociedad | 24 | 10 | 8 | 6 | 24 | 25 | -1 | 38 | LWOO | 12 | 6 | 4 | 2 | 9 | 6 | 12 | 4 | 4 | 4 | 15 | 19 | |
| 8 | Athletic Bilbao | 25 | 9 | 10 | 6 | 29 | 21 | +8 | 37 | WLWW | 12 | 6 | 2 | 4 | 19 | 13 | 13 | 3 | 8 | 2 | 10 | 8 | ||
| 9 | 1 | Celta Vigo | 25 | 8 | 8 | 9 | 29 | 26 | +3 | 32 | XOWX | 13 | 4 | 3 | 6 | 16 | 16 | 12 | 4 | 5 | 3 | 13 | 10 | |
| 10 | 1 | Osasuna | 25 | 8 | 8 | 9 | 25 | 30 | -5 | 32 | LWOW | 13 | 2 | 6 | 5 | 10 | 19 | 12 | 6 | 2 | 4 | 15 | 11 | |
| 11 | Rayo Vallecano | 24 | 9 | 4 | 11 | 28 | 29 | -1 | 31 | LLLL | 12 | 8 | 2 | 2 | 20 | 8 | 12 | 1 | 2 | 9 | 8 | 21 | ||
| 12 | Valencia | 25 | 7 | 9 | 9 | 37 | 42 | -5 | 30 | LLOL | 13 | 4 | 6 | 3 | 19 | 17 | 12 | 3 | 3 | 6 | 18 | 25 | ||
| 13 | 1 | Elche | 25 | 7 | 8 | 10 | 28 | 34 | -6 | 29 | WLWX | 12 | 5 | 5 | 2 | 15 | 12 | 13 | 2 | 3 | 8 | 13 | 22 | |
| 14 | 1 | Espanyol | 25 | 7 | 8 | 10 | 30 | 35 | -5 | 29 | XXLL | 13 | 6 | 4 | 3 | 19 | 16 | 12 | 1 | 4 | 7 | 11 | 19 | |
| 15 | 1 | Getafe | 25 | 6 | 8 | 11 | 24 | 28 | -4 | 26 | XLWO | 12 | 6 | 2 | 4 | 17 | 11 | 13 | 0 | 6 | 7 | 7 | 17 | |
| 16 | 1 | Mallorca | 24 | 6 | 8 | 10 | 23 | 38 | -15 | 26 | LWWL | 12 | 4 | 6 | 2 | 13 | 11 | 12 | 2 | 2 | 8 | 10 | 27 | |
| 17 | Granada | 25 | 5 | 9 | 11 | 27 | 40 | -13 | 24 | LLLL | 12 | 4 | 3 | 5 | 17 | 21 | 13 | 1 | 6 | 6 | 10 | 19 | ||
| 18 | Alavés | 25 | 5 | 5 | 15 | 19 | 42 | -23 | 20 | LWLL | 13 | 4 | 3 | 6 | 10 | 15 | 12 | 1 | 2 | 9 | 9 | 27 | ||
| 19 | Cádiz | 25 | 3 | 11 | 11 | 21 | 39 | -18 | 20 | XOLW | 13 | 0 | 8 | 5 | 9 | 18 | 12 | 3 | 3 | 6 | 12 | 21 | ||
| 20 | Levante | 25 | 2 | 9 | 14 | 25 | 51 | -26 | 15 | XWLL | 12 | 1 | 6 | 5 | 13 | 21 | 13 | 1 | 3 | 9 | 12 | 30 | ||
| 18 | +1 | Karim BENZEMA (Real Madrid, 3p) |
| 13 | Raúl DE TOMÁS (Espanyol, 4p) | |
| +1 | VINÍCIUS José JÚNIOR (Real Madrid) | |
| 12 | JOSELU (Alavés, 5p) | |
| JUANMI (Real Betis) | ||
| 11 | ENES Ünal (Getafe, 2p) | |
| IAGO Aspas (Celta Vigo, 2p) | ||
| +1 | Ángel CORREA (Atlético Madrid) | |
| 9 | +1 | Luis SUÁREZ (Atlético Madrid, 1p) |
| GONÇALO Manuel GUEDES (Valencia, 1p) | ||
| 8 | +3 | Arnaut DANJUMA (Villarreal, 1p) |
| MIKEL Oyarzabal (Real Sociedad, 3p) | ||
| GERARD Moreno (Villarreal, 1p) | ||
| +1 | CARLOS SOLER Barragán (Valencia, 5p) | |
| +1 | RAFA MIR (Sevilla) | |
| Memphis DEPAY (Barcelona, 3p) | ||
| 7 | PERE MILLA Peña (Elche) | |
| Lucas BOYÉ (Elche) | ||
| Jorge MOLINA (Granada) | ||
| SANTI MINA (Celta Vigo) | ||
| +1 | WILLIAN José (Real Betis, 3p) | |
| +1 | Marco ASENSIO (Real Madrid) | |
| BORJA IGLESIAS Quintas (Real Betis, 2p) |
| Friday, 18 February 2022 | |||||
| 25 | Elche | 2-1 | Rayo Vallecano | ||
| 76 | Carrillo | 52 | Fran García | ||
| 84 | Ponce | ||||
| Saturday, 19 February 2022 | |||||
| 25 | Real Madrid | 3-0 | Alavés | ||
| 63 | Asensio | ||||
| 80 | Vinícius Júnior | ||||
| 90(p) | Benzema | ||||
| 25 | Osasuna | 0-3 | Atlético Madrid | ||
| 3 | João Félix | ||||
| 59 | Suárez | ||||
| 89 | Correa | ||||
| 25 | Cádiz | 1-1 | Getafe | ||
| 45 | Negredo | 6(p) | Mayoral | ||
| 25 | Granada | 1-4 | Villarreal | ||
| 61(p) | Milla | 34 | Danjuma | ||
| 39 | Danjuma | ||||
| 72(p) | Danjuma | ||||
| 90 | Moi Gómez | ||||
| Sunday, 20 February 2022 | |||||
| 25 | Valencia | 1-4 | Barcelona | ||
| 52 | Carlos Soler | 22 | Aubameyang | ||
| 31 | De Jong | ||||
| 38 | Aubameyang | ||||
| 63 | Aubameyang | ||||
| 25 | Athletic Bilbao | 4-0 | Real Sociedad | ||
| 68 | Vivian | ||||
| 72 | Sancet | ||||
| 80 | Williams | ||||
| 89 | Muniain | ||||
| 25 | Espanyol | 1-1 | Sevilla | ||
| 50 | Sergi Darder | 36 | Rafa Mir | ||
| 25 | Real Betis | 2-1 | Mallorca | ||
| 25 | Álex Moreno | 75 | Muriqi | ||
| 83(p) | Willian | ||||
| Monday, 21 February 2022 | |||||
| 25 | Celta Vigo | 1-1 | Levante | ||
| 67 | Cervi | 82 | Roger | ||