| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 277 | 751 | 2.71 | 146 | 52.71% | 65 | 23.47% | 66 | 23.83% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | New York Red Bulls | 26 | 13 | 6 | 7 | 46 | 30 | +16 | 45 | WWLW | 13 | 9 | 2 | 2 | 25 | 10 | 13 | 4 | 4 | 5 | 21 | 20 | |
| 2 | 1 | D.C. United | 29 | 13 | 6 | 10 | 36 | 35 | +1 | 45 | XLLL | 14 | 9 | 3 | 2 | 27 | 18 | 15 | 4 | 3 | 8 | 9 | 17 | |
| 3 | Columbus Crew | 29 | 12 | 8 | 9 | 47 | 48 | -1 | 44 | WLWW | 15 | 8 | 4 | 3 | 32 | 23 | 14 | 4 | 4 | 6 | 15 | 25 | ||
| 4 | New England Revolution | 27 | 11 | 7 | 9 | 38 | 36 | +2 | 40 | WWWW | 14 | 8 | 5 | 1 | 24 | 9 | 13 | 3 | 2 | 8 | 14 | 27 | ||
| 5 | Toronto FC | 26 | 11 | 4 | 11 | 45 | 44 | +1 | 37 | LWWL | 11 | 7 | 1 | 3 | 22 | 12 | 15 | 4 | 3 | 8 | 23 | 32 | ||
| 6 | Montréal Impact | 25 | 9 | 5 | 11 | 34 | 37 | -3 | 32 | OWLL | 13 | 7 | 2 | 4 | 23 | 15 | 12 | 2 | 3 | 7 | 11 | 22 | ||
| 7 | Philadelphia Union | 29 | 8 | 6 | 15 | 36 | 47 | -11 | 30 | LWLW | 15 | 5 | 3 | 7 | 19 | 19 | 14 | 3 | 3 | 8 | 17 | 28 | ||
| 8 | Orlando City | 28 | 7 | 8 | 13 | 33 | 50 | -17 | 29 | LXLL | 14 | 4 | 5 | 5 | 18 | 16 | 14 | 3 | 3 | 8 | 15 | 34 | ||
| 9 | Chicago Fire | 28 | 7 | 6 | 15 | 36 | 45 | -9 | 27 | LLXW | 14 | 7 | 1 | 6 | 19 | 15 | 14 | 0 | 5 | 9 | 17 | 30 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Vancouver Whitecaps | 28 | 15 | 3 | 10 | 40 | 28 | +12 | 48 | WLWL | 13 | 8 | 1 | 4 | 23 | 13 | 15 | 7 | 2 | 6 | 17 | 15 | |
| 2 | 2 | FC Dallas | 27 | 14 | 5 | 8 | 40 | 31 | +9 | 47 | WWWL | 14 | 10 | 2 | 2 | 25 | 13 | 13 | 4 | 3 | 6 | 15 | 18 | |
| 3 | 2 | LA Galaxy | 29 | 13 | 8 | 8 | 49 | 33 | +16 | 47 | OLWW | 15 | 11 | 3 | 1 | 36 | 9 | 14 | 2 | 5 | 7 | 13 | 24 | |
| 4 | 1 | Seattle Sounders | 29 | 13 | 3 | 13 | 35 | 32 | +3 | 42 | XWWL | 15 | 10 | 1 | 4 | 22 | 12 | 14 | 3 | 2 | 9 | 13 | 20 | |
| 5 | Sporting Kansas City | 26 | 11 | 8 | 7 | 40 | 35 | +5 | 41 | OLLL | 13 | 8 | 4 | 1 | 23 | 15 | 13 | 3 | 4 | 6 | 17 | 20 | ||
| 6 | Portland Timbers | 28 | 11 | 8 | 9 | 29 | 32 | -3 | 41 | OLXW | 14 | 7 | 6 | 1 | 19 | 9 | 14 | 4 | 2 | 8 | 10 | 23 | ||
| 7 | San Jose Earthquakes | 28 | 11 | 6 | 11 | 34 | 32 | +2 | 39 | XLWW | 13 | 6 | 4 | 3 | 13 | 9 | 15 | 5 | 2 | 8 | 21 | 23 | ||
| 8 | Houston Dynamo | 28 | 9 | 8 | 11 | 36 | 37 | -1 | 35 | LWLX | 14 | 7 | 3 | 4 | 25 | 18 | 14 | 2 | 5 | 7 | 11 | 19 | ||
| 9 | 1 | Real Salt Lake | 28 | 9 | 8 | 11 | 32 | 41 | -9 | 35 | WLWL | 14 | 6 | 6 | 2 | 19 | 12 | 14 | 3 | 2 | 9 | 13 | 29 | |
| 10 | 1 | Colorado Rapids | 28 | 8 | 10 | 10 | 26 | 30 | -4 | 34 | XLWW | 15 | 5 | 5 | 5 | 18 | 20 | 13 | 3 | 5 | 5 | 8 | 10 | |
| 20 | +2 | Kei KAMARA (Columbus Crew) |
| 17 | Sebastian GIOVINCO (Toronto FC, 3p) | |
| 15 | Robbie KEANE (LA Galaxy, 4p) | |
| David VILLA (New York City, 5p) | ||
| 14 | +1 | Bradley WRIGHT-PHILLIPS (New York Red Bulls, 2p) |
| 13 | Chris WONDOLOWSKI (San Jose Earthquakes, 5p) | |
| 12 | +1 | Obafemi MARTINS (Seattle Sounders) |
| 11 | Cyle LARIN (Orlando City) | |
| 10 | Fanendo ADI (Portland Timbers, 1p) | |
| Will BRUIN (Houston Dynamo) | ||
| +1 | Octavio RIVERO (Vancouver Whitecaps, 3p) | |
| Jozy ALTIDORE (Toronto FC, 3p) | ||
| 9 | Fabián CASTILLO (FC Dallas) | |
| Chris ROLFE (D.C. United, 3p) | ||
| Dominic DWYER (Sporting Kansas City) | ||
| Charlie DAVIES (New England Revolution) | ||
| KAKÁ (Orlando City, 4p) | ||
| 8 | Krisztián NÉMETH (Sporting Kansas City) | |
| Ignacio PIATTI (Montréal Impact, 4p) | ||
| Clint DEMPSEY (Seattle Sounders, 1p) | ||
| Benny FEILHABER (Sporting Kansas City, 4p) | ||
| +1 | C.J. SAPONG (Philadelphia Union) | |
| +1 | David ACCAM (Chicago Fire) | |
| Ethan FINLAY (Columbus Crew) |
| Sunday, 6 September 2015 | |||||
| Columbus Crew | 0-3 | FC Dallas | |||
| 27 | Harris | ||||
| 69 | Barrios | ||||
| 71 | Texeira | ||||
| Wednesday, 9 September 2015 | |||||
| Vancouver Whitecaps | 2-0 | Colorado Rapids | |||
| 73 | Rivero | ||||
| 77 | Techera | ||||
| Portland Timbers | 0-0 | Sporting Kansas City | |||
| Friday, 11 September 2015 | |||||
| New York Red Bulls | 3-2 | Chicago Fire | |||
| 28 | Wright-Phillips | 14(p) | Larentowicz | ||
| 38 | Grella | 26 | Accam | ||
| 71(p) | Kljestan | ||||
| Saturday, 12 September 2015 | |||||
| FC Dallas | 2-1 | New York City | |||
| 45 | Michel | 70(p) | Mullins | ||
| 45 | Akindele | ||||
| Houston Dynamo | 1-3 | Real Salt Lake | |||
| 65(p) | Davis | 45 | Morales | ||
| 51 | Sandoval | ||||
| 68 | Martínez | ||||
| Colorado Rapids | 1-1 | D.C. United | |||
| 28 | Burling | 87 | Birnbaum | ||
| LA Galaxy | 0-0 | Montréal Impact | |||
| San Jose Earthquakes | 1-1 | Seattle Sounders | |||
| 70 | Alashe | 82 | Martins | ||
| Philadelphia Union | 1-2 | Columbus Crew | |||
| 66 | Sapong | 21 | Kamara | ||
| 26 | Kamara | ||||