| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 330 | 903 | 2.73 | 175 | 53.03% | 72 | 21.82% | 83 | 25.15% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New York Red Bulls | 33 | 17 | 6 | 10 | 60 | 42 | +18 | 57 | WLWW | 17 | 12 | 2 | 3 | 35 | 18 | 16 | 5 | 4 | 7 | 25 | 24 | ||
| 2 | 1 | D.C. United | 33 | 15 | 6 | 12 | 43 | 40 | +3 | 51 | WWLL | 17 | 11 | 3 | 3 | 34 | 21 | 16 | 4 | 3 | 9 | 9 | 19 | |
| 3 | 2 | Columbus Crew | 33 | 14 | 8 | 11 | 53 | 53 | +0 | 50 | WLLW | 16 | 8 | 4 | 4 | 33 | 25 | 17 | 6 | 4 | 7 | 20 | 28 | |
| 4 | 2 | Toronto FC | 33 | 15 | 4 | 14 | 57 | 56 | +1 | 49 | LWWW | 17 | 11 | 1 | 5 | 34 | 22 | 16 | 4 | 3 | 9 | 23 | 34 | |
| 5 | 1 | Montréal Impact | 33 | 14 | 6 | 13 | 46 | 43 | +3 | 48 | WWLL | 16 | 10 | 2 | 4 | 30 | 16 | 17 | 4 | 4 | 9 | 16 | 27 | |
| 6 | 2 | New England Revolution | 33 | 13 | 8 | 12 | 45 | 46 | -1 | 47 | LLXL | 17 | 9 | 6 | 2 | 27 | 12 | 16 | 4 | 2 | 10 | 18 | 34 | |
| 7 | Orlando City | 33 | 12 | 8 | 13 | 46 | 55 | -9 | 44 | WWWW | 17 | 7 | 5 | 5 | 25 | 19 | 16 | 5 | 3 | 8 | 21 | 36 | ||
| 8 | Philadelphia Union | 33 | 9 | 7 | 17 | 41 | 55 | -14 | 34 | LLXW | 16 | 6 | 3 | 7 | 21 | 19 | 17 | 3 | 4 | 10 | 20 | 36 | ||
| 9 | Chicago Fire | 33 | 8 | 6 | 19 | 42 | 56 | -14 | 30 | LWLL | 16 | 8 | 1 | 7 | 22 | 17 | 17 | 0 | 5 | 12 | 20 | 39 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | FC Dallas | 33 | 17 | 6 | 10 | 50 | 38 | +12 | 57 | WWOW | 16 | 12 | 2 | 2 | 31 | 14 | 17 | 5 | 4 | 8 | 19 | 24 | ||
| 2 | LA Galaxy | 33 | 14 | 9 | 10 | 55 | 44 | +11 | 51 | LXWL | 17 | 12 | 3 | 2 | 41 | 16 | 16 | 2 | 6 | 8 | 14 | 28 | ||
| 3 | Vancouver Whitecaps | 33 | 15 | 5 | 13 | 42 | 36 | +6 | 50 | LOXL | 16 | 8 | 2 | 6 | 24 | 18 | 17 | 7 | 3 | 7 | 18 | 18 | ||
| 4 | 2 | Portland Timbers | 33 | 14 | 8 | 11 | 37 | 38 | -1 | 50 | WWLW | 16 | 7 | 6 | 3 | 19 | 12 | 17 | 7 | 2 | 8 | 18 | 26 | |
| 5 | Seattle Sounders | 33 | 14 | 6 | 13 | 41 | 35 | +6 | 48 | XXXW | 16 | 10 | 2 | 4 | 23 | 13 | 17 | 4 | 4 | 9 | 18 | 22 | ||
| 6 | 2 | Sporting Kansas City | 33 | 13 | 9 | 11 | 46 | 44 | +2 | 48 | LLWX | 16 | 9 | 5 | 2 | 27 | 19 | 17 | 4 | 4 | 9 | 19 | 25 | |
| 7 | San Jose Earthquakes | 33 | 13 | 8 | 12 | 40 | 37 | +3 | 47 | WXWL | 17 | 8 | 6 | 3 | 17 | 11 | 16 | 5 | 2 | 9 | 23 | 26 | ||
| 8 | Houston Dynamo | 33 | 11 | 9 | 13 | 42 | 46 | -4 | 42 | XLWW | 17 | 9 | 4 | 4 | 30 | 21 | 16 | 2 | 5 | 9 | 12 | 25 | ||
| 9 | Real Salt Lake | 33 | 11 | 8 | 14 | 37 | 45 | -8 | 41 | LLWL | 17 | 7 | 6 | 4 | 22 | 14 | 16 | 4 | 2 | 10 | 15 | 31 | ||
| 10 | Colorado Rapids | 33 | 9 | 10 | 14 | 32 | 39 | -7 | 37 | WLLL | 17 | 5 | 5 | 7 | 19 | 23 | 16 | 4 | 5 | 7 | 13 | 16 | ||
| 22 | Kei KAMARA (Columbus Crew) | |
| Sebastian GIOVINCO (Toronto FC, 3p) | ||
| 19 | +2 | Robbie KEANE (LA Galaxy, 4p) |
| 17 | +2 | Cyle LARIN (Orlando City) |
| David VILLA (New York City, 6p) | ||
| 16 | Chris WONDOLOWSKI (San Jose Earthquakes, 6p) | |
| +1 | Bradley WRIGHT-PHILLIPS (New York Red Bulls, 2p) | |
| 15 | +2 | Fanendo ADI (Portland Timbers, 3p) |
| +1 | Obafemi MARTINS (Seattle Sounders) | |
| 12 | Jozy ALTIDORE (Toronto FC, 3p) | |
| 11 | Dominic DWYER (Sporting Kansas City) | |
| Will BRUIN (Houston Dynamo) | ||
| 10 | Krisztián NÉMETH (Sporting Kansas City) | |
| Chris ROLFE (D.C. United, 4p) | ||
| Lloyd SAM (New York Red Bulls) | ||
| Benny FEILHABER (Sporting Kansas City, 5p) | ||
| Octavio RIVERO (Vancouver Whitecaps, 3p) | ||
| David ACCAM (Chicago Fire) | ||
| +1 | Ethan FINLAY (Columbus Crew) | |
| 9 | Fabián CASTILLO (FC Dallas) | |
| +1 | Ignacio PIATTI (Montréal Impact, 4p) | |
| +2 | Mike GRELLA (New York Red Bulls) | |
| Charlie DAVIES (New England Revolution) | ||
| C.J. SAPONG (Philadelphia Union) | ||
| KAKÁ (Orlando City, 4p) | ||
| Didier DROGBA (Montréal Impact, 1p) |
| Friday, 16 October 2015 | |||||
| San Jose Earthquakes | 1-0 | Sporting Kansas City | |||
| 47 | Godoy | ||||
| Orlando City | 2-1 | New York City | |||
| 62 | Larin | 45 | Watson-Siriboe | ||
| 70 | Larin | ||||
| Saturday, 17 October 2015 | |||||
| New England Revolution | 0-1 | Montréal Impact | |||
| 55 | Piatti | ||||
| Real Salt Lake | 0-1 | FC Dallas | |||
| 57 | Texeira | ||||
| Toronto FC | 0-2 | Columbus Crew | |||
| 40 | Finlay | ||||
| 90 | Higuaín | ||||
| Sunday, 18 October 2015 | |||||
| D.C. United | 4-0 | Chicago Fire | |||
| 39 | Pontius | ||||
| 67 | Boswell | ||||
| 71 | Espíndola | ||||
| 80 | Saborio | ||||
| Houston Dynamo | 1-1 | Seattle Sounders | |||
| 65 | Clark | 82 | Martins | ||
| New York Red Bulls | 4-1 | Philadelphia Union | |||
| 1 | Grella | 55 | Le Toux | ||
| 4 | Wright-Phillips | ||||
| 17 | Grella | ||||
| 44 | Lawrence | ||||
| LA Galaxy | 2-5 | Portland Timbers | |||
| 36 | Keane | 65 | Adi | ||
| 84 | Keane | 68(p) | Adi | ||
| 74 | Chará | ||||
| 85 | Nagbe | ||||
| 90 | Urruti | ||||
| Wednesday, 21 October 2015 | |||||
| Sporting Kansas City | 0-2 | Colorado Rapids | |||
| 78 | Powers | ||||
| 86 | Marcelo | ||||