| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 340 | 937 | 2.75 | 183 | 53.82% | 72 | 21.18% | 85 | 25.00% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New York Red Bulls | 34 | 18 | 6 | 10 | 62 | 43 | +19 | 60 | WWLW | 17 | 12 | 2 | 3 | 35 | 18 | 17 | 6 | 4 | 7 | 27 | 25 | ||
| 2 | 3 | Columbus Crew | 34 | 15 | 8 | 11 | 58 | 53 | +5 | 53 | WWLL | 17 | 9 | 4 | 4 | 38 | 25 | 17 | 6 | 4 | 7 | 20 | 28 | |
| 3 | 3 | Montréal Impact | 34 | 15 | 6 | 13 | 48 | 44 | +4 | 51 | WWWL | 17 | 11 | 2 | 4 | 32 | 17 | 17 | 4 | 4 | 9 | 16 | 27 | |
| 4 | 1 | D.C. United | 34 | 15 | 6 | 13 | 43 | 45 | -2 | 51 | LWWL | 17 | 11 | 3 | 3 | 34 | 21 | 17 | 4 | 3 | 10 | 9 | 24 | |
| 5 | 1 | New England Revolution | 34 | 14 | 8 | 12 | 48 | 47 | +1 | 50 | WLLX | 17 | 9 | 6 | 2 | 27 | 12 | 17 | 5 | 2 | 10 | 21 | 35 | |
| 6 | 4 | Toronto FC | 34 | 15 | 4 | 15 | 58 | 58 | +0 | 49 | LLWW | 17 | 11 | 1 | 5 | 34 | 22 | 17 | 4 | 3 | 10 | 24 | 36 | |
| 7 | Orlando City | 34 | 12 | 8 | 14 | 46 | 56 | -10 | 44 | LWWW | 17 | 7 | 5 | 5 | 25 | 19 | 17 | 5 | 3 | 9 | 21 | 37 | ||
| 8 | Philadelphia Union | 34 | 10 | 7 | 17 | 42 | 55 | -13 | 37 | WLLX | 17 | 7 | 3 | 7 | 22 | 19 | 17 | 3 | 4 | 10 | 20 | 36 | ||
| 9 | Chicago Fire | 34 | 8 | 6 | 20 | 43 | 58 | -15 | 30 | LLWL | 17 | 8 | 1 | 8 | 23 | 19 | 17 | 0 | 5 | 12 | 20 | 39 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | FC Dallas | 34 | 18 | 6 | 10 | 52 | 39 | +13 | 60 | WWWO | 17 | 13 | 2 | 2 | 33 | 15 | 17 | 5 | 4 | 8 | 19 | 24 | ||
| 2 | 1 | Vancouver Whitecaps | 34 | 16 | 5 | 13 | 45 | 36 | +9 | 53 | WLOX | 17 | 9 | 2 | 6 | 27 | 18 | 17 | 7 | 3 | 7 | 18 | 18 | |
| 3 | 3 | Portland Timbers | 34 | 15 | 8 | 11 | 41 | 39 | +2 | 53 | WWWL | 17 | 8 | 6 | 3 | 23 | 13 | 17 | 7 | 2 | 8 | 18 | 26 | |
| 4 | 1 | Seattle Sounders | 34 | 15 | 6 | 13 | 44 | 36 | +8 | 51 | WXXX | 17 | 11 | 2 | 4 | 26 | 14 | 17 | 4 | 4 | 9 | 18 | 22 | |
| 5 | 3 | LA Galaxy | 34 | 14 | 9 | 11 | 56 | 46 | +10 | 51 | LLXW | 17 | 12 | 3 | 2 | 41 | 16 | 17 | 2 | 6 | 9 | 15 | 30 | |
| 6 | 2 | Sporting Kansas City | 34 | 14 | 9 | 11 | 48 | 45 | +3 | 51 | WLLW | 17 | 10 | 5 | 2 | 29 | 20 | 17 | 4 | 4 | 9 | 19 | 25 | |
| 7 | San Jose Earthquakes | 34 | 13 | 8 | 13 | 41 | 39 | +2 | 47 | LWXW | 17 | 8 | 6 | 3 | 17 | 11 | 17 | 5 | 2 | 10 | 24 | 28 | ||
| 8 | Houston Dynamo | 34 | 11 | 9 | 14 | 42 | 49 | -7 | 42 | LXLW | 17 | 9 | 4 | 4 | 30 | 21 | 17 | 2 | 5 | 10 | 12 | 28 | ||
| 9 | Real Salt Lake | 34 | 11 | 8 | 15 | 38 | 48 | -10 | 41 | LLLW | 17 | 7 | 6 | 4 | 22 | 14 | 17 | 4 | 2 | 11 | 16 | 34 | ||
| 10 | Colorado Rapids | 34 | 9 | 10 | 15 | 33 | 43 | -10 | 37 | LWLL | 17 | 5 | 5 | 7 | 19 | 23 | 17 | 4 | 5 | 8 | 14 | 20 | ||
| Sunday, 25 October 2015 | |||||
| FC Dallas | 2-1 | San Jose Earthquakes | |||
| Columbus Crew | 5-0 | D.C. United | |||
| Sporting Kansas City | 2-1 | LA Galaxy | |||
| Chicago Fire | 1-2 | New York Red Bulls | |||
| Vancouver Whitecaps | 3-0 | Houston Dynamo | |||
| Montréal Impact | 2-1 | Toronto FC | |||
| Portland Timbers | 4-1 | Colorado Rapids | |||
| Seattle Sounders | 3-1 | Real Salt Lake | |||
| Philadelphia Union | 1-0 | Orlando City | |||
| New York City | 1-3 | New England Revolution | |||
| 22 | Kei KAMARA (Columbus Crew) | |
| Sebastian GIOVINCO (Toronto FC, 3p) | ||
| 20 | +1 | Robbie KEANE (LA Galaxy, 4p) |
| 18 | +1 | David VILLA (New York City, 7p) |
| 17 | Cyle LARIN (Orlando City) | |
| +1 | Bradley WRIGHT-PHILLIPS (New York Red Bulls, 2p) | |
| 16 | +1 | Fanendo ADI (Portland Timbers, 3p) |
| Chris WONDOLOWSKI (San Jose Earthquakes, 6p) | ||
| 15 | Obafemi MARTINS (Seattle Sounders) | |
| 13 | +1 | Jozy ALTIDORE (Toronto FC, 3p) |
| 12 | +1 | Dominic DWYER (Sporting Kansas City) |
| +2 | Ethan FINLAY (Columbus Crew) | |
| 11 | Will BRUIN (Houston Dynamo) | |
| +2 | Didier DROGBA (Montréal Impact, 1p) | |
| 10 | Krisztián NÉMETH (Sporting Kansas City) | |
| Chris ROLFE (D.C. United, 4p) | ||
| Lloyd SAM (New York Red Bulls) | ||
| +2 | Clint DEMPSEY (Seattle Sounders, 1p) | |
| +1 | Charlie DAVIES (New England Revolution) | |
| Benny FEILHABER (Sporting Kansas City, 5p) | ||
| Octavio RIVERO (Vancouver Whitecaps, 3p) | ||
| David ACCAM (Chicago Fire) |