| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 235 | 662 | 2.81 | 104 | 44.26% | 66 | 28.09% | 65 | 27.66% |
| Group E | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 16 | 10 | 3 | 3 | 32 | 18 | +14 | 33 | WXWW | 9 | 5 | 3 | 1 | 20 | 11 | 7 | 5 | 0 | 2 | 12 | 7 | ||
| 2 | FC Cincinnati | 16 | 9 | 3 | 4 | 24 | 22 | +2 | 30 | XLXW | 7 | 5 | 2 | 0 | 13 | 7 | 9 | 4 | 1 | 4 | 11 | 15 | ||
| 3 | Nashville | 16 | 8 | 4 | 4 | 28 | 19 | +9 | 28 | XWOW | 9 | 6 | 2 | 1 | 19 | 7 | 7 | 2 | 2 | 3 | 9 | 12 | ||
| 4 | 1 | Columbus Crew | 16 | 7 | 7 | 2 | 26 | 19 | +7 | 28 | XLXX | 9 | 4 | 4 | 1 | 15 | 10 | 7 | 3 | 3 | 1 | 11 | 9 | |
| 5 | 1 | Orlando City | 16 | 7 | 6 | 3 | 30 | 19 | +11 | 27 | LWWW | 8 | 5 | 2 | 1 | 20 | 11 | 8 | 2 | 4 | 2 | 10 | 8 | |
| 6 | 1 | Inter Miami | 15 | 7 | 5 | 3 | 31 | 26 | +5 | 26 | WXLX | 8 | 4 | 2 | 2 | 17 | 14 | 7 | 3 | 3 | 1 | 14 | 12 | |
| 7 | 2 | New York Red Bulls | 16 | 7 | 3 | 6 | 26 | 19 | +7 | 24 | WWLL | 8 | 6 | 1 | 1 | 21 | 8 | 8 | 1 | 2 | 5 | 5 | 11 | |
| 8 | 2 | New York City | 16 | 7 | 3 | 6 | 18 | 18 | +0 | 24 | LWWO | 9 | 6 | 0 | 3 | 12 | 9 | 7 | 1 | 3 | 3 | 6 | 9 | |
| 9 | 1 | Charlotte FC | 16 | 7 | 1 | 8 | 26 | 27 | -1 | 22 | LWLL | 8 | 6 | 0 | 2 | 17 | 9 | 8 | 1 | 1 | 6 | 9 | 18 | |
| 10 | New England Revolution | 14 | 5 | 5 | 4 | 16 | 14 | +2 | 20 | XXOX | 5 | 2 | 1 | 2 | 4 | 4 | 9 | 3 | 4 | 2 | 12 | 10 | ||
| 11 | Chicago Fire | 14 | 5 | 4 | 5 | 25 | 27 | -2 | 19 | LWWO | 6 | 1 | 4 | 1 | 7 | 7 | 8 | 4 | 0 | 4 | 18 | 20 | ||
| 12 | Atlanta United | 16 | 4 | 5 | 7 | 21 | 28 | -7 | 17 | WWLX | 10 | 4 | 3 | 3 | 17 | 15 | 6 | 0 | 2 | 4 | 4 | 13 | ||
| 13 | D.C. United | 16 | 3 | 6 | 7 | 14 | 28 | -14 | 15 | XLOO | 9 | 2 | 4 | 3 | 8 | 10 | 7 | 1 | 2 | 4 | 6 | 18 | ||
| 14 | Toronto FC | 16 | 3 | 4 | 9 | 18 | 22 | -4 | 13 | LLWL | 9 | 1 | 2 | 6 | 5 | 10 | 7 | 2 | 2 | 3 | 13 | 12 | ||
| 15 | CF Montréal | 16 | 1 | 5 | 10 | 12 | 29 | -17 | 8 | LXLX | 6 | 0 | 3 | 3 | 5 | 12 | 10 | 1 | 2 | 7 | 7 | 17 | ||
| Group W | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Vancouver Whitecaps | 15 | 9 | 5 | 1 | 27 | 12 | +15 | 32 | OWOX | 8 | 5 | 2 | 1 | 16 | 8 | 7 | 4 | 3 | 0 | 11 | 4 | ||
| 2 | San Diego FC | 16 | 8 | 3 | 5 | 27 | 18 | +9 | 27 | LWOW | 9 | 5 | 3 | 1 | 17 | 7 | 7 | 3 | 0 | 4 | 10 | 11 | ||
| 3 | Minnesota United | 16 | 7 | 6 | 3 | 23 | 14 | +9 | 27 | OXWL | 8 | 4 | 3 | 1 | 14 | 7 | 8 | 3 | 3 | 2 | 9 | 7 | ||
| 4 | 1 | Seattle Sounders | 16 | 7 | 5 | 4 | 23 | 19 | +4 | 26 | WWXL | 7 | 5 | 2 | 0 | 16 | 5 | 9 | 2 | 3 | 4 | 7 | 14 | |
| 5 | 1 | Portland Timbers | 16 | 7 | 5 | 4 | 25 | 22 | +3 | 26 | WLXO | 8 | 4 | 3 | 1 | 13 | 11 | 8 | 3 | 2 | 3 | 12 | 11 | |
| 6 | 2 | Los Angeles | 15 | 6 | 5 | 4 | 27 | 22 | +5 | 23 | XXWX | 7 | 5 | 1 | 1 | 12 | 4 | 8 | 1 | 4 | 3 | 15 | 18 | |
| 7 | 1 | San Jose Earthquakes | 16 | 6 | 4 | 6 | 33 | 26 | +7 | 22 | WXOX | 9 | 3 | 3 | 3 | 25 | 17 | 7 | 3 | 1 | 3 | 8 | 9 | |
| 8 | 1 | Colorado Rapids | 16 | 6 | 4 | 6 | 18 | 22 | -4 | 22 | LWWL | 8 | 4 | 2 | 2 | 11 | 11 | 8 | 2 | 2 | 4 | 7 | 11 | |
| 9 | 1 | Houston Dynamo | 16 | 5 | 5 | 6 | 21 | 22 | -1 | 20 | WXWW | 8 | 3 | 1 | 4 | 11 | 13 | 8 | 2 | 4 | 2 | 10 | 9 | |
| 10 | 1 | Austin FC | 16 | 5 | 5 | 6 | 11 | 18 | -7 | 20 | XXOX | 9 | 3 | 4 | 2 | 6 | 7 | 7 | 2 | 1 | 4 | 5 | 11 | |
| 11 | FC Dallas | 15 | 4 | 5 | 6 | 18 | 26 | -8 | 17 | XLLX | 6 | 1 | 1 | 4 | 4 | 9 | 9 | 3 | 4 | 2 | 14 | 17 | ||
| 12 | Real Salt Lake | 16 | 4 | 3 | 9 | 16 | 23 | -7 | 15 | XLLO | 7 | 2 | 1 | 4 | 7 | 8 | 9 | 2 | 2 | 5 | 9 | 15 | ||
| 13 | Sporting Kansas City | 15 | 3 | 4 | 8 | 22 | 27 | -5 | 13 | XOXL | 7 | 2 | 2 | 3 | 12 | 14 | 8 | 1 | 2 | 5 | 10 | 13 | ||
| 14 | St. Louis CITY SC | 15 | 2 | 5 | 8 | 11 | 20 | -9 | 11 | LLXL | 7 | 1 | 3 | 3 | 5 | 7 | 8 | 1 | 2 | 5 | 6 | 13 | ||
| 15 | LA Galaxy | 16 | 0 | 4 | 12 | 13 | 36 | -23 | 4 | LLXL | 7 | 0 | 2 | 5 | 6 | 15 | 9 | 0 | 2 | 7 | 7 | 21 | ||
| 13 | Tai BARIBO (Philadelphia Union) | |
| 10 | Brian WHITE (Vancouver Whitecaps) | |
| 9 | +1 | Kévin DENKEY (FC Cincinnati) |
| +2 | Eric CHOUPO-MOTING (New York Red Bulls) | |
| +1 | Sam SURRIDGE (Nashville) | |
| Cristian ARANGO (San Jose Earthquakes) | ||
| 8 | +2 | Lionel MESSI (Inter Miami) |
| Hugo CUYPERS (Chicago Fire) | ||
| Martín OJEDA (Orlando City) | ||
| Diego LUNA (Real Salt Lake) | ||
| +1 | Diego ROSSI (Columbus Crew) | |
| Alonso MARTÍNEZ (New York City) | ||
| 7 | Denis BOUANGA (Los Angeles) | |
| Albert RUSNÁK (Seattle Sounders) | ||
| +1 | Hany MUKHTAR (Nashville) | |
| +1 | Djordje MIHAILOVIC (Colorado Rapids) | |
| EVANDER da Silva (FC Cincinnati) | ||
| Dejan JOVELJIĆ (Sporting Kansas City) | ||
| 6 | Josef MARTÍNEZ (San Jose Earthquakes) | |
| CARLES GIL de Pareja (New England Revolution) | ||
| Luis MURIEL (Orlando City) | ||
| Christian BENTEKE (D.C. United) | ||
| Tani OLUWASEYI (Minnesota United) | ||
| Anders DREYER (San Diego FC) | ||
| Marco PAŠALIĆ (Orlando City) |
| Wednesday, 28 May 2025 | |||||
| D.C. United | 1-1 | New England Revolution | |||
| 90+1 | Gabriel Pirani | 45+3 | Feingold | ||
| New York Red Bulls | 4-2 | Charlotte FC | |||
| 14 | Bogacz | 26 | Vargas | ||
| 29 | Sofo | 76 | Abada | ||
| 70(p) | Choupo-Moting | ||||
| 90+7(p) | Choupo-Moting | ||||
| Columbus Crew | 2-2 | Nashville | |||
| 69 | Rossi | 2 | Surridge | ||
| 81(og) | Palacios | 78 | Mukhtar | ||
| LA Galaxy | 0-1 | San Jose Earthquakes | |||
| 74 | Bouda | ||||
| Vancouver Whitecaps | 0-0 | Minnesota United | |||
| Portland Timbers | 2-1 | Colorado Rapids | |||
| 59 | Antony | 33 | Mihailovic | ||
| 76 | Kelsy | ||||
| Seattle Sounders | 1-0 | San Diego FC | |||
| 58 | Ferreira | ||||
| Toronto FC | 1-2 | Philadelphia Union | |||
| 75 | Brynhildsen | 86 | Harriel | ||
| 90+2 | Wagner | ||||
| Austin FC | 1-1 | Real Salt Lake | |||
| 90+3 | Rubio | 67 | Agada | ||
| New York City | 0-3 | Houston Dynamo | |||
| 26(og) | Haak | ||||
| 50 | Segal | ||||
| 90+4(p) | Segal | ||||
| Atlanta United | 3-2 | Orlando City | |||
| 19 | Miranchuk | 4 | Araújo | ||
| 83 | Slisz | 32 | Enrique | ||
| 90+5 | Thiaré | ||||
| FC Cincinnati | 3-3 | FC Dallas | |||
| 30 | Bucha | 50 | Musa | ||
| 42(p) | Denkey | 68 | Julio | ||
| 86 | Valenzuela | 90+2 | Ibeagha | ||
| Inter Miami | 4-2 | CF Montréal | |||
| 27 | Messi | 74 | Sealy | ||
| 68 | Suárez | 90+2 | Loturi | ||
| 71 | Suárez | ||||
| 87 | Messi | ||||