| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 510 | 1,530 | 3.00 | 223 | 43.73% | 128 | 25.10% | 159 | 31.18% |
| Group E | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 34 | 20 | 6 | 8 | 57 | 35 | +22 | 66 | LWWW | 17 | 12 | 4 | 1 | 36 | 15 | 17 | 8 | 2 | 7 | 21 | 20 | ||
| 2 | FC Cincinnati | 34 | 20 | 5 | 9 | 52 | 40 | +12 | 65 | WWXW | 17 | 9 | 3 | 5 | 27 | 19 | 17 | 11 | 2 | 4 | 25 | 21 | ||
| 3 | Inter Miami | 34 | 19 | 8 | 7 | 81 | 55 | +26 | 65 | WWWL | 17 | 11 | 3 | 3 | 44 | 26 | 17 | 8 | 5 | 4 | 37 | 29 | ||
| 4 | Charlotte FC | 34 | 19 | 2 | 13 | 55 | 46 | +9 | 59 | WWLL | 17 | 13 | 1 | 3 | 33 | 16 | 17 | 6 | 1 | 10 | 22 | 30 | ||
| 5 | New York City | 34 | 17 | 5 | 12 | 50 | 44 | +6 | 56 | LLWL | 17 | 11 | 0 | 6 | 28 | 21 | 17 | 6 | 5 | 6 | 22 | 23 | ||
| 6 | Nashville | 34 | 16 | 6 | 12 | 58 | 45 | +13 | 54 | LXWL | 17 | 11 | 3 | 3 | 36 | 17 | 17 | 5 | 3 | 9 | 22 | 28 | ||
| 7 | 2 | Columbus Crew | 34 | 14 | 12 | 8 | 55 | 51 | +4 | 54 | WXLX | 17 | 9 | 5 | 3 | 29 | 20 | 17 | 5 | 7 | 5 | 26 | 31 | |
| 8 | Chicago Fire | 34 | 15 | 8 | 11 | 68 | 60 | +8 | 53 | XXWW | 17 | 6 | 6 | 5 | 25 | 25 | 17 | 9 | 2 | 6 | 43 | 35 | ||
| 9 | 2 | Orlando City | 34 | 14 | 11 | 9 | 63 | 51 | +12 | 53 | LLXX | 17 | 8 | 4 | 5 | 36 | 26 | 17 | 6 | 7 | 4 | 27 | 25 | |
| 10 | New York Red Bulls | 34 | 12 | 7 | 15 | 48 | 47 | +1 | 43 | LLLW | 17 | 10 | 3 | 4 | 36 | 23 | 17 | 2 | 4 | 11 | 12 | 24 | ||
| 11 | New England Revolution | 34 | 9 | 9 | 16 | 44 | 51 | -7 | 36 | XLWL | 17 | 4 | 4 | 9 | 20 | 25 | 17 | 5 | 5 | 7 | 24 | 26 | ||
| 12 | Toronto FC | 34 | 6 | 14 | 14 | 37 | 44 | -7 | 32 | WLXX | 17 | 3 | 7 | 7 | 17 | 19 | 17 | 3 | 7 | 7 | 20 | 25 | ||
| 13 | CF Montréal | 34 | 6 | 10 | 18 | 34 | 60 | -26 | 28 | LXWL | 17 | 2 | 6 | 9 | 14 | 33 | 17 | 4 | 4 | 9 | 20 | 27 | ||
| 14 | Atlanta United | 34 | 5 | 13 | 16 | 38 | 63 | -25 | 28 | XLLL | 17 | 4 | 8 | 5 | 29 | 29 | 17 | 1 | 5 | 11 | 9 | 34 | ||
| 15 | D.C. United | 34 | 5 | 11 | 18 | 30 | 66 | -36 | 26 | XLLL | 17 | 2 | 7 | 8 | 13 | 31 | 17 | 3 | 4 | 10 | 17 | 35 | ||
| Group W | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | San Diego FC | 34 | 19 | 6 | 9 | 64 | 41 | +23 | 63 | WWLX | 17 | 7 | 5 | 5 | 25 | 17 | 17 | 12 | 1 | 4 | 39 | 24 | ||
| 2 | 1 | Vancouver Whitecaps | 34 | 18 | 9 | 7 | 66 | 38 | +28 | 63 | LWWX | 17 | 10 | 4 | 3 | 42 | 20 | 17 | 8 | 5 | 4 | 24 | 18 | |
| 3 | 1 | Los Angeles | 34 | 17 | 9 | 8 | 65 | 40 | +25 | 60 | XLWW | 17 | 11 | 2 | 4 | 31 | 13 | 17 | 6 | 7 | 4 | 34 | 27 | |
| 4 | 2 | Minnesota United | 34 | 16 | 10 | 8 | 56 | 39 | +17 | 58 | LWXL | 17 | 8 | 4 | 5 | 29 | 20 | 17 | 8 | 6 | 3 | 27 | 19 | |
| 5 | Seattle Sounders | 34 | 15 | 10 | 9 | 58 | 48 | +10 | 55 | WWWX | 17 | 10 | 6 | 1 | 38 | 20 | 17 | 5 | 4 | 8 | 20 | 28 | ||
| 6 | Austin FC | 34 | 13 | 8 | 13 | 37 | 45 | -8 | 47 | LWLL | 17 | 7 | 7 | 3 | 18 | 16 | 17 | 6 | 1 | 10 | 19 | 29 | ||
| 7 | 1 | FC Dallas | 34 | 11 | 11 | 12 | 52 | 55 | -3 | 44 | WLWX | 17 | 6 | 3 | 8 | 25 | 25 | 17 | 5 | 8 | 4 | 27 | 30 | |
| 8 | 1 | Portland Timbers | 34 | 11 | 11 | 12 | 41 | 48 | -7 | 44 | LLXX | 17 | 7 | 6 | 4 | 25 | 26 | 17 | 4 | 5 | 8 | 16 | 22 | |
| 9 | Real Salt Lake | 34 | 12 | 5 | 17 | 38 | 49 | -11 | 41 | XLWW | 17 | 9 | 1 | 7 | 23 | 21 | 17 | 3 | 4 | 10 | 15 | 28 | ||
| 10 | 1 | San Jose Earthquakes | 34 | 11 | 8 | 15 | 60 | 63 | -3 | 41 | WLWL | 17 | 5 | 6 | 6 | 37 | 32 | 17 | 6 | 2 | 9 | 23 | 31 | |
| 11 | 1 | Colorado Rapids | 34 | 11 | 8 | 15 | 44 | 56 | -12 | 41 | XLXL | 17 | 8 | 4 | 5 | 25 | 21 | 17 | 3 | 4 | 10 | 19 | 35 | |
| 12 | Houston Dynamo | 34 | 9 | 10 | 15 | 43 | 56 | -13 | 37 | OLLW | 17 | 5 | 3 | 9 | 20 | 30 | 17 | 4 | 7 | 6 | 23 | 26 | ||
| 13 | St. Louis CITY SC | 34 | 8 | 8 | 18 | 44 | 58 | -14 | 32 | XWLW | 17 | 4 | 6 | 7 | 23 | 28 | 17 | 4 | 2 | 11 | 21 | 30 | ||
| 14 | 1 | LA Galaxy | 34 | 7 | 9 | 18 | 46 | 66 | -20 | 30 | WWLW | 17 | 7 | 2 | 8 | 27 | 28 | 17 | 0 | 7 | 10 | 19 | 38 | |
| 15 | 1 | Sporting Kansas City | 34 | 7 | 7 | 20 | 46 | 70 | -24 | 28 | OLLL | 17 | 4 | 5 | 8 | 25 | 32 | 17 | 3 | 2 | 12 | 21 | 38 | |
| 29 | +5 | Lionel MESSI (Inter Miami) |
| 24 | +1 | Denis BOUANGA (Los Angeles) |
| +1 | Sam SURRIDGE (Nashville) | |
| 19 | +2 | Anders DREYER (San Diego FC) |
| 18 | +1 | EVANDER da Silva (FC Cincinnati) |
| Petar MUSA (FC Dallas) | ||
| Dejan JOVELJIĆ (Sporting Kansas City) | ||
| 17 | +1 | Eric CHOUPO-MOTING (New York Red Bulls) |
| Hugo CUYPERS (Chicago Fire) | ||
| Alonso MARTÍNEZ (New York City) | ||
| 16 | Martín OJEDA (Orlando City) | |
| Tai BARIBO (Philadelphia Union) | ||
| Diego ROSSI (Columbus Crew) | ||
| Hany MUKHTAR (Nashville) | ||
| Brian WHITE (Vancouver Whitecaps) | ||
| 15 | Kévin DENKEY (FC Cincinnati) | |
| +1 | Philip ZINCKERNAGEL (Chicago Fire) | |
| 14 | +1 | Josef MARTÍNEZ (San Jose Earthquakes) |
| Danny MUSOVSKI (Seattle Sounders) | ||
| 13 | +2 | Djordje MIHAILOVIC (Toronto FC) |
| Cristian ARANGO (San Jose Earthquakes) | ||
| Prince-Osei OWUSU (CF Montréal) | ||
| 12 | RAFAEL NAVARRO Leal (Colorado Rapids) | |
| Marco PAŠALIĆ (Orlando City) | ||
| Milan ILOSKI (Philadelphia Union) | ||
| 11 | Tadeo ALLENDE (Inter Miami) | |
| Emil FORSBERG (New York Red Bulls) | ||
| Albert RUSNÁK (Seattle Sounders) | ||
| Hannes WOLF (New York City) | ||
| Idan TOKLOMATI (Charlotte FC) |
| Sunday, 5 October 2025 | |||||
| Vancouver Whitecaps | 4-1 | San Jose Earthquakes | |||
| 39 | Elloumi | 89 | Leroux | ||
| 57 | Müller | ||||
| 74 | Berhalter | ||||
| 90+2 | Berhalter | ||||
| Los Angeles | 1-0 | Atlanta United | |||
| 86 | Bouanga | ||||
| Wednesday, 8 October 2025 | |||||
| Los Angeles | 2-0 | Toronto FC | |||
| 13 | Ebobisse | ||||
| 69 | Amaya | ||||
| Saturday, 11 October 2025 | |||||
| LA Galaxy | 2-1 | FC Dallas | |||
| 42 | Wynder | 52 | Julio | ||
| 87 | Gabriel Pec | ||||
| Seattle Sounders | 1-0 | Real Salt Lake | |||
| 4 | Rothrock | ||||
| Orlando City | 1-2 | Vancouver Whitecaps | |||
| 24 | Þórhallsson | 81 | Pierre | ||
| 90+7 | Müller | ||||
| Inter Miami | 4-0 | Atlanta United | |||
| 39 | Messi | ||||
| 52 | Jordi Alba | ||||
| 61 | Suárez | ||||
| 87 | Messi | ||||
| Sunday, 12 October 2025 | |||||
| Austin FC | 1-0 | Los Angeles | |||
| 83 | Wolff | ||||
| Saturday, 18 October 2025 | |||||
| Colorado Rapids | 2-2 | Los Angeles | |||
| 62 | Aaronson | 42 | Son | ||
| 87 | Yapi | 90 | Moran | ||
| Columbus Crew | 3-1 | New York Red Bulls | |||
| 16 | Herrera | 11 | Choupo-Moting | ||
| 66 | Gazdag | ||||
| 84 | Aliyu | ||||
| New England Revolution | 2-2 | Chicago Fire | |||
| 1 | Yusuf | 82 | Zinckernagel | ||
| 90+6 | Turgeman | 90+9(og) | Turgeman | ||
| Sporting Kansas City | 0-0 | Houston Dynamo | |||
| LA Galaxy | 2-1 | Minnesota United | |||
| 12 | Matheus Nascimento | 90+6 | Pereyra | ||
| 52 | Paintsil | ||||
| Vancouver Whitecaps | 1-2 | FC Dallas | |||
| 28(p) | Müller | 18 | Urhoghide | ||
| 47 | Kaick | ||||
| Portland Timbers | 0-4 | San Diego FC | |||
| 26 | Pellegrino | ||||
| 47 | Dreyer | ||||
| 49 | Dreyer | ||||
| 63 | Pellegrino | ||||
| Toronto FC | 4-2 | Orlando City | |||
| 7 | Osorio | 54 | Brekalo | ||
| 34 | Mihailovic | 90+2 | McGuire | ||
| 48 | Mihailovic | ||||
| 61 | Kerr | ||||
| San Jose Earthquakes | 2-1 | Austin FC | |||
| 74 | Martínez | 22 | Wolff | ||
| 77 | Tsakiris | ||||
| Nashville | 2-5 | Inter Miami | |||
| 43 | Surridge | 35 | Messi | ||
| 45+6 | Shaffelburg | 63(p) | Messi | ||
| 67 | Rodríguez | ||||
| 81 | Messi | ||||
| 90+1 | Segovia | ||||
| New York City | 1-2 | Seattle Sounders | |||
| 82 | Fernandez Mercau | 61 | Morris | ||
| 87 | Ragen | ||||
| Atlanta United | 1-1 | D.C. United | |||
| 3 | Almiron | 67 | Gabriel Pirani | ||
| FC Cincinnati | 3-0 | CF Montréal | |||
| 33 | Hagglund | ||||
| 56 | Evander | ||||
| 88 | Brenner | ||||
| Charlotte FC | 2-0 | Philadelphia Union | |||
| 24 | Zaha | ||||
| 30 | Vargas | ||||
| St. Louis CITY SC | 2-2 | Real Salt Lake | |||
| 42(p) | Löwen | 17 | Olatunji | ||
| 88 | Klauss | 32 | Olatunji | ||