| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 454 | 1,351 | 2.97 | 197 | 43.39% | 114 | 25.11% | 143 | 31.50% |
| Group E | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 31 | 18 | 6 | 7 | 50 | 33 | +17 | 60 | WLWW | 16 | 11 | 4 | 1 | 35 | 15 | 15 | 7 | 2 | 6 | 15 | 18 | ||
| 2 | FC Cincinnati | 31 | 18 | 4 | 9 | 47 | 39 | +8 | 58 | WWLL | 15 | 8 | 2 | 5 | 23 | 18 | 16 | 10 | 2 | 4 | 24 | 21 | ||
| 3 | Charlotte FC | 31 | 17 | 2 | 12 | 51 | 42 | +9 | 53 | LWWW | 15 | 12 | 1 | 2 | 30 | 12 | 16 | 5 | 1 | 10 | 21 | 30 | ||
| 4 | 3 | New York City | 30 | 16 | 5 | 9 | 46 | 35 | +11 | 53 | WWWL | 15 | 11 | 0 | 4 | 27 | 15 | 15 | 5 | 5 | 5 | 19 | 20 | |
| 5 | 3 | Inter Miami | 28 | 15 | 7 | 6 | 60 | 46 | +14 | 52 | WWLX | 14 | 9 | 3 | 2 | 33 | 20 | 14 | 6 | 4 | 4 | 27 | 26 | |
| 6 | Orlando City | 30 | 14 | 9 | 7 | 58 | 43 | +15 | 51 | WXLW | 15 | 8 | 3 | 4 | 34 | 23 | 15 | 6 | 6 | 3 | 24 | 20 | ||
| 7 | 3 | Nashville | 31 | 15 | 5 | 11 | 52 | 38 | +14 | 50 | LLLW | 15 | 10 | 3 | 2 | 31 | 11 | 16 | 5 | 2 | 9 | 21 | 27 | |
| 8 | 3 | Columbus Crew | 31 | 13 | 11 | 7 | 51 | 47 | +4 | 50 | XLWO | 16 | 8 | 5 | 3 | 26 | 19 | 15 | 5 | 6 | 4 | 25 | 28 | |
| 9 | Chicago Fire | 30 | 13 | 6 | 11 | 57 | 53 | +4 | 45 | WLWL | 15 | 5 | 5 | 5 | 21 | 23 | 15 | 8 | 1 | 6 | 36 | 30 | ||
| 10 | New York Red Bulls | 31 | 12 | 7 | 12 | 45 | 40 | +5 | 43 | WLOL | 15 | 10 | 3 | 2 | 34 | 19 | 16 | 2 | 4 | 10 | 11 | 21 | ||
| 11 | New England Revolution | 31 | 8 | 8 | 15 | 39 | 45 | -6 | 32 | LXLL | 15 | 3 | 3 | 9 | 16 | 23 | 16 | 5 | 5 | 6 | 23 | 22 | ||
| 12 | Toronto FC | 30 | 5 | 12 | 13 | 30 | 37 | -7 | 27 | XXXO | 15 | 2 | 6 | 7 | 12 | 16 | 15 | 3 | 6 | 6 | 18 | 21 | ||
| 13 | Atlanta United | 30 | 5 | 12 | 13 | 37 | 55 | -18 | 27 | XLWO | 16 | 4 | 7 | 5 | 28 | 28 | 14 | 1 | 5 | 8 | 9 | 27 | ||
| 14 | D.C. United | 31 | 5 | 10 | 16 | 29 | 58 | -29 | 25 | LXWX | 15 | 2 | 7 | 6 | 13 | 24 | 16 | 3 | 3 | 10 | 16 | 34 | ||
| 15 | CF Montréal | 31 | 5 | 9 | 17 | 29 | 55 | -26 | 24 | LLXW | 16 | 2 | 5 | 9 | 13 | 32 | 15 | 3 | 4 | 8 | 16 | 23 | ||
| Group W | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | San Diego FC | 31 | 17 | 6 | 8 | 56 | 38 | +18 | 57 | XLWO | 16 | 7 | 5 | 4 | 25 | 16 | 15 | 10 | 1 | 4 | 31 | 22 | ||
| 2 | 1 | Vancouver Whitecaps | 29 | 16 | 7 | 6 | 56 | 31 | +25 | 55 | WWWX | 14 | 9 | 3 | 2 | 36 | 16 | 15 | 7 | 4 | 4 | 20 | 15 | |
| 3 | 1 | Minnesota United | 31 | 15 | 9 | 7 | 51 | 36 | +15 | 54 | LWXW | 16 | 7 | 4 | 5 | 26 | 20 | 15 | 8 | 5 | 2 | 25 | 16 | |
| 4 | 1 | Los Angeles | 28 | 13 | 8 | 7 | 53 | 36 | +17 | 47 | WWLX | 14 | 8 | 2 | 4 | 24 | 12 | 14 | 5 | 6 | 3 | 29 | 24 | |
| 5 | 1 | Seattle Sounders | 29 | 12 | 9 | 8 | 51 | 43 | +8 | 45 | LXWL | 14 | 8 | 5 | 1 | 34 | 18 | 15 | 4 | 4 | 7 | 17 | 25 | |
| 6 | Portland Timbers | 30 | 11 | 9 | 10 | 38 | 40 | -2 | 42 | LWXO | 15 | 7 | 5 | 3 | 23 | 20 | 15 | 4 | 4 | 7 | 15 | 20 | ||
| 7 | Austin FC | 29 | 11 | 8 | 10 | 31 | 36 | -5 | 41 | LWWL | 14 | 5 | 7 | 2 | 14 | 12 | 15 | 6 | 1 | 8 | 17 | 24 | ||
| 8 | Colorado Rapids | 31 | 11 | 6 | 14 | 41 | 52 | -11 | 39 | LWLL | 15 | 8 | 2 | 5 | 22 | 18 | 16 | 3 | 4 | 9 | 19 | 34 | ||
| 9 | 2 | FC Dallas | 30 | 9 | 10 | 11 | 45 | 49 | -4 | 37 | WWXX | 16 | 5 | 3 | 8 | 23 | 24 | 14 | 4 | 7 | 3 | 22 | 25 | |
| 10 | 2 | Houston Dynamo | 31 | 9 | 9 | 13 | 40 | 49 | -9 | 36 | WLXW | 16 | 5 | 3 | 8 | 18 | 26 | 15 | 4 | 6 | 5 | 22 | 23 | |
| 11 | 2 | San Jose Earthquakes | 31 | 9 | 8 | 14 | 56 | 58 | -2 | 35 | LLLW | 16 | 4 | 6 | 6 | 35 | 31 | 15 | 5 | 2 | 8 | 21 | 27 | |
| 12 | 2 | Real Salt Lake | 29 | 10 | 4 | 15 | 31 | 41 | -10 | 34 | LWLL | 15 | 7 | 1 | 7 | 19 | 20 | 14 | 3 | 3 | 8 | 12 | 21 | |
| 13 | 1 | St. Louis CITY SC | 31 | 7 | 7 | 17 | 39 | 52 | -13 | 28 | WWXL | 15 | 4 | 5 | 6 | 21 | 23 | 16 | 3 | 2 | 11 | 18 | 29 | |
| 14 | 1 | Sporting Kansas City | 31 | 7 | 6 | 18 | 45 | 63 | -18 | 27 | LLLW | 16 | 4 | 4 | 8 | 25 | 32 | 15 | 3 | 2 | 10 | 20 | 31 | |
| 15 | LA Galaxy | 30 | 4 | 9 | 17 | 37 | 61 | -24 | 21 | LXXW | 14 | 4 | 2 | 8 | 19 | 25 | 16 | 0 | 7 | 9 | 18 | 36 | ||
| 22 | +3 | Lionel MESSI (Inter Miami) |
| 21 | Sam SURRIDGE (Nashville) | |
| 19 | +1 | Denis BOUANGA (Los Angeles) |
| 17 | +2 | Alonso MARTÍNEZ (New York City) |
| EVANDER da Silva (FC Cincinnati) | ||
| Dejan JOVELJIĆ (Sporting Kansas City) | ||
| 16 | +1 | Eric CHOUPO-MOTING (New York Red Bulls) |
| Hugo CUYPERS (Chicago Fire) | ||
| +2 | Martín OJEDA (Orlando City) | |
| Tai BARIBO (Philadelphia Union) | ||
| Diego ROSSI (Columbus Crew) | ||
| +1 | Petar MUSA (FC Dallas) | |
| 15 | +1 | Anders DREYER (San Diego FC) |
| +1 | Hany MUKHTAR (Nashville) | |
| 14 | +1 | Philip ZINCKERNAGEL (Chicago Fire) |
| Brian WHITE (Vancouver Whitecaps) | ||
| Danny MUSOVSKI (Seattle Sounders) | ||
| 13 | Kévin DENKEY (FC Cincinnati) | |
| +1 | Cristian ARANGO (San Jose Earthquakes) | |
| 12 | Josef MARTÍNEZ (San Jose Earthquakes) | |
| RAFAEL NAVARRO Leal (Colorado Rapids) | ||
| Prince-Osei OWUSU (CF Montréal) | ||
| 11 | +2 | Hannes WOLF (New York City) |
| Marco PAŠALIĆ (Orlando City) | ||
| Milan ILOSKI (Philadelphia Union) | ||
| Idan TOKLOMATI (Charlotte FC) |
| Tuesday, 16 September 2025 | |||||
| Inter Miami | 3-1 | Seattle Sounders | |||
| 12 | Jordi Alba | 69 | Vargas | ||
| 41 | Messi | ||||
| 52 | Fray | ||||
| Wednesday, 17 September 2025 | |||||
| Real Salt Lake | 1-4 | Los Angeles | |||
| 76 | Gozo | 3 | Son | ||
| 16 | Son | ||||
| 82 | Son | ||||
| 88 | Bouanga | ||||
| New York City | 3-2 | Columbus Crew | |||
| 45+3 | Wolf | 40(p) | Gazdag | ||
| 73 | Wolf | 60 | Abou Ali | ||
| 90+4 | Fernández | ||||
| Saturday, 20 September 2025 | |||||
| FC Dallas | 3-1 | Colorado Rapids | |||
| 14 | Musa | 21 | Harris | ||
| 36 | Cappis | ||||
| 80(og) | Maxsø | ||||
| Houston Dynamo | 1-0 | Portland Timbers | |||
| 44 | Ponce | ||||
| Columbus Crew | 1-1 | Toronto FC | |||
| 16 | Abou Ali | 51 | Laryea | ||
| Sporting Kansas City | 0-2 | Vancouver Whitecaps | |||
| 2 | Ocampo | ||||
| 43 | Cabrera | ||||
| LA Galaxy | 2-3 | FC Cincinnati | |||
| 39 | Paintsil | 10 | Echenique | ||
| 90+1 | Cuevas | 22 | Brenner | ||
| 88 | Brenner | ||||
| CF Montréal | 0-2 | New York Red Bulls | |||
| 23 | Parker | ||||
| 29 | Choupo-Moting | ||||
| San Jose Earthquakes | 1-3 | St. Louis CITY SC | |||
| 31(p) | Arango | 10 | McSorley | ||
| 19 | Hartel | ||||
| 45 | McSorley | ||||
| Orlando City | 3-2 | Nashville | |||
| 30 | Ojeda | 45+1 | Mukhtar | ||
| 32 | Ojeda | 51 | Shaffelburg | ||
| 90+5 | McGuire | ||||
| Philadelphia Union | 1-0 | New England Revolution | |||
| 71 | Damiani | ||||
| Minnesota United | 0-3 | Chicago Fire | |||
| 26 | Waterman | ||||
| 41 | D'Avilla | ||||
| 70 | Zinckernagel | ||||
| New York City | 2-0 | Charlotte FC | |||
| 11(p) | Martínez | ||||
| 58(p) | Martínez | ||||
| Atlanta United | 1-1 | San Diego FC | |||
| 61(p) | Almiron | 32 | Dreyer | ||
| Inter Miami | 3-2 | D.C. United | |||
| 35 | Allende | 53 | Benteke | ||
| 66 | Messi | 90+7 | Murrell | ||
| 85 | Messi | ||||