| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 266 | 765 | 2.87 | 117 | 43.98% | 70 | 26.32% | 79 | 29.70% |
| Group E | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 18 | 11 | 4 | 3 | 34 | 19 | +15 | 37 | WOWX | 10 | 6 | 3 | 1 | 22 | 12 | 8 | 5 | 1 | 2 | 12 | 7 | ||
| 2 | FC Cincinnati | 18 | 10 | 3 | 5 | 26 | 24 | +2 | 33 | WLXL | 8 | 5 | 2 | 1 | 14 | 9 | 10 | 5 | 1 | 4 | 12 | 15 | ||
| 3 | 1 | Nashville | 18 | 9 | 5 | 4 | 32 | 21 | +11 | 32 | WXXW | 10 | 6 | 3 | 1 | 21 | 9 | 8 | 3 | 2 | 3 | 11 | 12 | |
| 4 | 1 | Columbus Crew | 18 | 8 | 7 | 3 | 29 | 25 | +4 | 31 | WLXL | 10 | 5 | 4 | 1 | 17 | 11 | 8 | 3 | 3 | 2 | 12 | 14 | |
| 5 | 2 | Orlando City | 18 | 8 | 6 | 4 | 32 | 22 | +10 | 30 | WLLW | 9 | 5 | 2 | 2 | 21 | 14 | 9 | 3 | 4 | 2 | 11 | 8 | |
| 6 | 3 | Inter Miami | 16 | 8 | 5 | 3 | 36 | 27 | +9 | 29 | WWXL | 9 | 5 | 2 | 2 | 22 | 15 | 7 | 3 | 3 | 1 | 14 | 12 | |
| 7 | 2 | New York City | 18 | 8 | 4 | 6 | 24 | 20 | +4 | 28 | WXLW | 10 | 7 | 0 | 3 | 16 | 9 | 8 | 1 | 4 | 3 | 8 | 11 | |
| 8 | 2 | New York Red Bulls | 18 | 8 | 3 | 7 | 29 | 21 | +8 | 27 | LWWW | 9 | 7 | 1 | 1 | 23 | 8 | 9 | 1 | 2 | 6 | 6 | 13 | |
| 9 | 1 | Charlotte FC | 18 | 8 | 1 | 9 | 29 | 29 | +0 | 25 | LWLW | 8 | 6 | 0 | 2 | 17 | 9 | 10 | 2 | 1 | 7 | 12 | 20 | |
| 10 | 1 | Chicago Fire | 17 | 7 | 4 | 6 | 35 | 31 | +4 | 25 | LWWL | 7 | 1 | 4 | 2 | 7 | 9 | 10 | 6 | 0 | 4 | 28 | 22 | |
| 11 | 1 | New England Revolution | 16 | 6 | 5 | 5 | 19 | 15 | +4 | 23 | LWXX | 6 | 2 | 1 | 3 | 4 | 5 | 10 | 4 | 4 | 2 | 15 | 10 | |
| 12 | D.C. United | 19 | 4 | 6 | 9 | 17 | 38 | -21 | 18 | LLWX | 10 | 2 | 4 | 4 | 9 | 17 | 9 | 2 | 2 | 5 | 8 | 21 | ||
| 13 | Atlanta United | 18 | 4 | 5 | 9 | 21 | 34 | -13 | 17 | LLWW | 10 | 4 | 3 | 3 | 17 | 15 | 8 | 0 | 2 | 6 | 4 | 19 | ||
| 14 | Toronto FC | 17 | 3 | 4 | 10 | 18 | 24 | -6 | 13 | LLLW | 10 | 1 | 2 | 7 | 5 | 12 | 7 | 2 | 2 | 3 | 13 | 12 | ||
| 15 | CF Montréal | 18 | 2 | 5 | 11 | 15 | 33 | -18 | 11 | WLLX | 7 | 0 | 3 | 4 | 5 | 15 | 11 | 2 | 2 | 7 | 10 | 18 | ||
| Group W | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Vancouver Whitecaps | 17 | 10 | 5 | 2 | 31 | 14 | +17 | 35 | LWOW | 9 | 6 | 2 | 1 | 19 | 8 | 8 | 4 | 3 | 1 | 12 | 6 | ||
| 2 | San Diego FC | 18 | 10 | 3 | 5 | 33 | 20 | +13 | 33 | WWLW | 10 | 6 | 3 | 1 | 19 | 7 | 8 | 4 | 0 | 4 | 14 | 13 | ||
| 3 | Minnesota United | 18 | 8 | 6 | 4 | 28 | 20 | +8 | 30 | LWOX | 9 | 4 | 3 | 2 | 16 | 11 | 9 | 4 | 3 | 2 | 12 | 9 | ||
| 4 | Portland Timbers | 18 | 8 | 6 | 4 | 28 | 24 | +4 | 30 | XWWL | 10 | 5 | 4 | 1 | 16 | 13 | 8 | 3 | 2 | 3 | 12 | 11 | ||
| 5 | 1 | Los Angeles | 16 | 7 | 5 | 4 | 30 | 23 | +7 | 26 | WXXW | 8 | 6 | 1 | 1 | 15 | 5 | 8 | 1 | 4 | 3 | 15 | 18 | |
| 6 | 1 | Seattle Sounders | 18 | 7 | 5 | 6 | 25 | 25 | +0 | 26 | LLWW | 8 | 5 | 2 | 1 | 18 | 8 | 10 | 2 | 3 | 5 | 7 | 17 | |
| 7 | 3 | Austin FC | 19 | 7 | 5 | 7 | 15 | 21 | -6 | 26 | WWLX | 10 | 4 | 4 | 2 | 8 | 8 | 9 | 3 | 1 | 5 | 7 | 13 | |
| 8 | 1 | San Jose Earthquakes | 18 | 6 | 5 | 7 | 35 | 29 | +6 | 23 | XLWX | 9 | 3 | 3 | 3 | 25 | 17 | 9 | 3 | 2 | 4 | 10 | 12 | |
| 9 | 1 | Colorado Rapids | 18 | 6 | 4 | 8 | 18 | 25 | -7 | 22 | LLLW | 10 | 4 | 2 | 4 | 11 | 14 | 8 | 2 | 2 | 4 | 7 | 11 | |
| 10 | 1 | FC Dallas | 17 | 5 | 6 | 6 | 22 | 28 | -6 | 21 | WOXL | 7 | 1 | 2 | 4 | 4 | 9 | 10 | 4 | 4 | 2 | 18 | 19 | |
| 11 | 2 | Houston Dynamo | 18 | 5 | 5 | 8 | 23 | 28 | -5 | 20 | LLWX | 10 | 3 | 1 | 6 | 13 | 19 | 8 | 2 | 4 | 2 | 10 | 9 | |
| 12 | 1 | Real Salt Lake | 18 | 5 | 3 | 10 | 18 | 25 | -7 | 18 | WLXL | 8 | 3 | 1 | 4 | 9 | 8 | 10 | 2 | 2 | 6 | 9 | 17 | |
| 13 | 1 | Sporting Kansas City | 18 | 4 | 4 | 10 | 28 | 35 | -7 | 16 | LLWX | 8 | 2 | 2 | 4 | 14 | 18 | 10 | 2 | 2 | 6 | 14 | 17 | |
| 14 | St. Louis CITY SC | 18 | 3 | 6 | 9 | 17 | 26 | -9 | 15 | XLWL | 9 | 2 | 4 | 3 | 10 | 11 | 9 | 1 | 2 | 6 | 7 | 15 | ||
| 15 | LA Galaxy | 18 | 1 | 5 | 12 | 18 | 39 | -21 | 8 | XWLL | 8 | 1 | 2 | 5 | 8 | 15 | 10 | 0 | 3 | 7 | 10 | 24 | ||
| 13 | Tai BARIBO (Philadelphia Union) | |
| 12 | +1 | Sam SURRIDGE (Nashville) |
| 11 | +1 | Kévin DENKEY (FC Cincinnati) |
| 10 | Lionel MESSI (Inter Miami) | |
| Eric CHOUPO-MOTING (New York Red Bulls) | ||
| Hugo CUYPERS (Chicago Fire) | ||
| Brian WHITE (Vancouver Whitecaps) | ||
| +1 | Dejan JOVELJIĆ (Sporting Kansas City) | |
| 9 | +1 | Martín OJEDA (Orlando City) |
| +1 | Diego ROSSI (Columbus Crew) | |
| Cristian ARANGO (San Jose Earthquakes) | ||
| 8 | +1 | Denis BOUANGA (Los Angeles) |
| Tani OLUWASEYI (Minnesota United) | ||
| Diego LUNA (Real Salt Lake) | ||
| +2 | Anders DREYER (San Diego FC) | |
| Alonso MARTÍNEZ (New York City) | ||
| +1 | Hany MUKHTAR (Nashville) | |
| +2 | Hannes WOLF (New York City) | |
| 7 | Josef MARTÍNEZ (San Jose Earthquakes) | |
| +1 | Philip ZINCKERNAGEL (Chicago Fire) | |
| Albert RUSNÁK (Seattle Sounders) | ||
| Djordje MIHAILOVIC (Colorado Rapids) | ||
| EVANDER da Silva (FC Cincinnati) |
| Saturday, 7 June 2025 | |||||
| D.C. United | 1-7 | Chicago Fire | |||
| 60 | Badji | 8 | Haile-Selassie | ||
| 24 | Bamba | ||||
| 30 | Barlow | ||||
| 44 | Barlow | ||||
| 56 | Zinckernagel | ||||
| 65 | Barlow | ||||
| 90+1 | Gutiérrez | ||||
| Colorado Rapids | 0-2 | Austin FC | |||
| 6 | Desler | ||||
| 66(og) | Rafael Navarro | ||||
| Sunday, 8 June 2025 | |||||
| Vancouver Whitecaps | 3-0 | Seattle Sounders | |||
| 40 | Badwal | ||||
| 70 | Rios | ||||
| 88(p) | Kreilach | ||||
| Portland Timbers | 2-1 | St. Louis CITY SC | |||
| 55 | Antony | 50 | Watts | ||
| 90+2 | Ayala | ||||
| Los Angeles | 3-1 | Sporting Kansas City | |||
| 45+1 | Segura | 39 | Joveljić | ||
| 59(p) | Bouanga | ||||
| 90+3 | Giroud | ||||
| Thursday, 12 June 2025 | |||||
| New York City | 4-0 | Atlanta United | |||
| 44 | Moralez | ||||
| 55 | Bakrar | ||||
| 57 | Wolf | ||||
| 59 | Wolf | ||||
| Friday, 13 June 2025 | |||||
| Portland Timbers | 1-1 | San Jose Earthquakes | |||
| 71 | Mosquera | 90+3 | Judd | ||
| Saturday, 14 June 2025 | |||||
| Houston Dynamo | 1-3 | CF Montréal | |||
| 64 | Lingr | 30 | Owusu | ||
| 32 | Owusu | ||||
| 54 | Neal | ||||
| Colorado Rapids | 0-1 | Orlando City | |||
| 24 | Ojeda | ||||
| Columbus Crew | 2-1 | Vancouver Whitecaps | |||
| 2 | Aliyu | 6 | Ngando | ||
| 23 | Rossi | ||||
| New England Revolution | 0-1 | FC Cincinnati | |||
| 26 | Denkey | ||||
| Sporting Kansas City | 2-4 | FC Dallas | |||
| 8 | Suleimanov | 11 | Musa | ||
| 90+1 | Muñóz | 59(p) | Acosta | ||
| 69 | Kamungo | ||||
| 82 | Acosta | ||||
| Chicago Fire | 0-2 | Nashville | |||
| 56 | Mukhtar | ||||
| 75 | Surridge | ||||
| Real Salt Lake | 2-0 | D.C. United | |||
| 23 | Russell | ||||
| 77 | Gozo | ||||
| Philadelphia Union | 2-1 | Charlotte FC | |||
| 45+2 | Bueno | 78 | Zaha | ||
| 90+8 | Anderson | ||||
| Minnesota United | 2-4 | San Diego FC | |||
| 8(og) | McVey | 11 | Dreyer | ||
| 38 | Yeboah | 66(p) | Dreyer | ||
| 75 | Iloski | ||||
| 90+2 | Iloski | ||||
| Austin FC | 2-1 | New York Red Bulls | |||
| 6 | Guilherme Biro | 23(og) | Vázquez | ||
| 51 | Vázquez | ||||
| St. Louis CITY SC | 3-3 | LA Galaxy | |||
| 35 | Klauss | 41 | Gabriel Pec | ||
| 47 | Klauss | 51 | Matheus Nascimento | ||
| 90+5 | Klauss | 87 | Gabriel Pec | ||