| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 510 | 1,530 | 3.00 | 223 | 43.73% | 128 | 25.10% | 159 | 31.18% |
| Group E | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 34 | 20 | 6 | 8 | 57 | 35 | +22 | 66 | LWWW | 17 | 12 | 4 | 1 | 36 | 15 | 17 | 8 | 2 | 7 | 21 | 20 | ||
| 2 | FC Cincinnati | 34 | 20 | 5 | 9 | 52 | 40 | +12 | 65 | WWXW | 17 | 9 | 3 | 5 | 27 | 19 | 17 | 11 | 2 | 4 | 25 | 21 | ||
| 3 | 1 | Inter Miami | 34 | 19 | 8 | 7 | 81 | 55 | +26 | 65 | WWWL | 17 | 11 | 3 | 3 | 44 | 26 | 17 | 8 | 5 | 4 | 37 | 29 | |
| 4 | 1 | Charlotte FC | 34 | 19 | 2 | 13 | 55 | 46 | +9 | 59 | WWLL | 17 | 13 | 1 | 3 | 33 | 16 | 17 | 6 | 1 | 10 | 22 | 30 | |
| 5 | 2 | New York City | 34 | 17 | 5 | 12 | 50 | 44 | +6 | 56 | LLWL | 17 | 11 | 0 | 6 | 28 | 21 | 17 | 6 | 5 | 6 | 22 | 23 | |
| 6 | Nashville | 34 | 16 | 6 | 12 | 58 | 45 | +13 | 54 | LXWL | 17 | 11 | 3 | 3 | 36 | 17 | 17 | 5 | 3 | 9 | 22 | 28 | ||
| 7 | 1 | Columbus Crew | 34 | 14 | 12 | 8 | 55 | 51 | +4 | 54 | WXLX | 17 | 9 | 5 | 3 | 29 | 20 | 17 | 5 | 7 | 5 | 26 | 31 | |
| 8 | 1 | Chicago Fire | 34 | 15 | 8 | 11 | 68 | 60 | +8 | 53 | XXWW | 17 | 6 | 6 | 5 | 25 | 25 | 17 | 9 | 2 | 6 | 43 | 35 | |
| 9 | 2 | Orlando City | 34 | 14 | 11 | 9 | 63 | 51 | +12 | 53 | LLXX | 17 | 8 | 4 | 5 | 36 | 26 | 17 | 6 | 7 | 4 | 27 | 25 | |
| 10 | New York Red Bulls | 34 | 12 | 7 | 15 | 48 | 47 | +1 | 43 | LLLW | 17 | 10 | 3 | 4 | 36 | 23 | 17 | 2 | 4 | 11 | 12 | 24 | ||
| 11 | New England Revolution | 34 | 9 | 9 | 16 | 44 | 51 | -7 | 36 | XLWL | 17 | 4 | 4 | 9 | 20 | 25 | 17 | 5 | 5 | 7 | 24 | 26 | ||
| 12 | Toronto FC | 34 | 6 | 14 | 14 | 37 | 44 | -7 | 32 | WLXX | 17 | 3 | 7 | 7 | 17 | 19 | 17 | 3 | 7 | 7 | 20 | 25 | ||
| 13 | CF Montréal | 34 | 6 | 10 | 18 | 34 | 60 | -26 | 28 | LXWL | 17 | 2 | 6 | 9 | 14 | 33 | 17 | 4 | 4 | 9 | 20 | 27 | ||
| 14 | Atlanta United | 34 | 5 | 13 | 16 | 38 | 63 | -25 | 28 | XLLL | 17 | 4 | 8 | 5 | 29 | 29 | 17 | 1 | 5 | 11 | 9 | 34 | ||
| 15 | D.C. United | 34 | 5 | 11 | 18 | 30 | 66 | -36 | 26 | XLLL | 17 | 2 | 7 | 8 | 13 | 31 | 17 | 3 | 4 | 10 | 17 | 35 | ||
| Group W | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | San Diego FC | 34 | 19 | 6 | 9 | 64 | 41 | +23 | 63 | WWLX | 17 | 7 | 5 | 5 | 25 | 17 | 17 | 12 | 1 | 4 | 39 | 24 | ||
| 2 | Vancouver Whitecaps | 34 | 18 | 9 | 7 | 66 | 38 | +28 | 63 | LWWX | 17 | 10 | 4 | 3 | 42 | 20 | 17 | 8 | 5 | 4 | 24 | 18 | ||
| 3 | 1 | Los Angeles | 34 | 17 | 9 | 8 | 65 | 40 | +25 | 60 | XLWW | 17 | 11 | 2 | 4 | 31 | 13 | 17 | 6 | 7 | 4 | 34 | 27 | |
| 4 | 1 | Minnesota United | 34 | 16 | 10 | 8 | 56 | 39 | +17 | 58 | LWXL | 17 | 8 | 4 | 5 | 29 | 20 | 17 | 8 | 6 | 3 | 27 | 19 | |
| 5 | Seattle Sounders | 34 | 15 | 10 | 9 | 58 | 48 | +10 | 55 | WWWX | 17 | 10 | 6 | 1 | 38 | 20 | 17 | 5 | 4 | 8 | 20 | 28 | ||
| 6 | Austin FC | 34 | 13 | 8 | 13 | 37 | 45 | -8 | 47 | LWLL | 17 | 7 | 7 | 3 | 18 | 16 | 17 | 6 | 1 | 10 | 19 | 29 | ||
| 7 | 3 | FC Dallas | 34 | 11 | 11 | 12 | 52 | 55 | -3 | 44 | WLWX | 17 | 6 | 3 | 8 | 25 | 25 | 17 | 5 | 8 | 4 | 27 | 30 | |
| 8 | 1 | Portland Timbers | 34 | 11 | 11 | 12 | 41 | 48 | -7 | 44 | LLXX | 17 | 7 | 6 | 4 | 25 | 26 | 17 | 4 | 5 | 8 | 16 | 22 | |
| 9 | 2 | Real Salt Lake | 34 | 12 | 5 | 17 | 38 | 49 | -11 | 41 | XLWW | 17 | 9 | 1 | 7 | 23 | 21 | 17 | 3 | 4 | 10 | 15 | 28 | |
| 10 | 1 | San Jose Earthquakes | 34 | 11 | 8 | 15 | 60 | 63 | -3 | 41 | WLWL | 17 | 5 | 6 | 6 | 37 | 32 | 17 | 6 | 2 | 9 | 23 | 31 | |
| 11 | 3 | Colorado Rapids | 34 | 11 | 8 | 15 | 44 | 56 | -12 | 41 | XLXL | 17 | 8 | 4 | 5 | 25 | 21 | 17 | 3 | 4 | 10 | 19 | 35 | |
| 12 | Houston Dynamo | 34 | 9 | 10 | 15 | 43 | 56 | -13 | 37 | OLLW | 17 | 5 | 3 | 9 | 20 | 30 | 17 | 4 | 7 | 6 | 23 | 26 | ||
| 13 | St. Louis CITY SC | 34 | 8 | 8 | 18 | 44 | 58 | -14 | 32 | XWLW | 17 | 4 | 6 | 7 | 23 | 28 | 17 | 4 | 2 | 11 | 21 | 30 | ||
| 14 | 1 | LA Galaxy | 34 | 7 | 9 | 18 | 46 | 66 | -20 | 30 | WWLW | 17 | 7 | 2 | 8 | 27 | 28 | 17 | 0 | 7 | 10 | 19 | 38 | |
| 15 | 1 | Sporting Kansas City | 34 | 7 | 7 | 20 | 46 | 70 | -24 | 28 | OLLL | 17 | 4 | 5 | 8 | 25 | 32 | 17 | 3 | 2 | 12 | 21 | 38 | |
| Saturday, 18 October 2025 | |||||
| Colorado Rapids | 2-2 | Los Angeles | |||
| Columbus Crew | 3-1 | New York Red Bulls | |||
| New England Revolution | 2-2 | Chicago Fire | |||
| Sporting Kansas City | 0-0 | Houston Dynamo | |||
| LA Galaxy | 2-1 | Minnesota United | |||
| Vancouver Whitecaps | 1-2 | FC Dallas | |||
| Portland Timbers | 0-4 | San Diego FC | |||
| Toronto FC | 4-2 | Orlando City | |||
| San Jose Earthquakes | 2-1 | Austin FC | |||
| Nashville | 2-5 | Inter Miami | |||
| New York City | 1-2 | Seattle Sounders | |||
| Atlanta United | 1-1 | D.C. United | |||
| FC Cincinnati | 3-0 | CF Montréal | |||
| Charlotte FC | 2-0 | Philadelphia Union | |||
| St. Louis CITY SC | 2-2 | Real Salt Lake | |||
| 29 | +5 | Lionel MESSI (Inter Miami) |
| 24 | +1 | Denis BOUANGA (Los Angeles) |
| +1 | Sam SURRIDGE (Nashville) | |
| 19 | +2 | Anders DREYER (San Diego FC) |
| 18 | +1 | EVANDER da Silva (FC Cincinnati) |
| Petar MUSA (FC Dallas) | ||
| Dejan JOVELJIĆ (Sporting Kansas City) | ||
| 17 | +1 | Eric CHOUPO-MOTING (New York Red Bulls) |
| Hugo CUYPERS (Chicago Fire) | ||
| Alonso MARTÍNEZ (New York City) | ||
| 16 | Martín OJEDA (Orlando City) | |
| Tai BARIBO (Philadelphia Union) | ||
| Diego ROSSI (Columbus Crew) | ||
| Hany MUKHTAR (Nashville) | ||
| Brian WHITE (Vancouver Whitecaps) | ||
| 15 | Kévin DENKEY (FC Cincinnati) | |
| +1 | Philip ZINCKERNAGEL (Chicago Fire) | |
| 14 | +1 | Josef MARTÍNEZ (San Jose Earthquakes) |
| Danny MUSOVSKI (Seattle Sounders) | ||
| 13 | +2 | Djordje MIHAILOVIC (Toronto FC) |
| Cristian ARANGO (San Jose Earthquakes) | ||
| Prince-Osei OWUSU (CF Montréal) | ||
| 12 | RAFAEL NAVARRO Leal (Colorado Rapids) | |
| Marco PAŠALIĆ (Orlando City) | ||
| Milan ILOSKI (Philadelphia Union) | ||
| 11 | Tadeo ALLENDE (Inter Miami) | |
| Emil FORSBERG (New York Red Bulls) | ||
| Albert RUSNÁK (Seattle Sounders) | ||
| Hannes WOLF (New York City) | ||
| Idan TOKLOMATI (Charlotte FC) |