| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 408 | 1,200 | 2.94 | 179 | 43.87% | 104 | 25.49% | 125 | 30.64% |
| Group E | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Philadelphia Union | 28 | 16 | 6 | 6 | 48 | 26 | +22 | 54 | WLXW | 15 | 10 | 4 | 1 | 34 | 15 | 13 | 6 | 2 | 5 | 14 | 11 | |
| 2 | 1 | FC Cincinnati | 28 | 16 | 4 | 8 | 42 | 35 | +7 | 52 | LWLO | 13 | 7 | 2 | 4 | 21 | 16 | 15 | 9 | 2 | 4 | 21 | 19 | |
| 3 | Nashville | 28 | 15 | 5 | 8 | 49 | 32 | +17 | 50 | WLLL | 14 | 10 | 3 | 1 | 31 | 10 | 14 | 5 | 2 | 7 | 18 | 22 | ||
| 4 | 3 | Charlotte FC | 28 | 15 | 2 | 11 | 46 | 39 | +7 | 47 | WWWW | 14 | 11 | 1 | 2 | 27 | 12 | 14 | 4 | 1 | 9 | 19 | 27 | |
| 5 | 1 | Orlando City | 28 | 13 | 8 | 7 | 54 | 40 | +14 | 47 | LWWW | 14 | 7 | 3 | 4 | 31 | 21 | 14 | 6 | 5 | 3 | 23 | 19 | |
| 6 | 1 | Inter Miami | 25 | 13 | 7 | 5 | 54 | 40 | +14 | 46 | XWLO | 12 | 7 | 3 | 2 | 27 | 17 | 13 | 6 | 4 | 3 | 27 | 23 | |
| 7 | 1 | Columbus Crew | 27 | 12 | 9 | 6 | 43 | 39 | +4 | 45 | LXLW | 15 | 8 | 4 | 3 | 25 | 18 | 12 | 4 | 5 | 3 | 18 | 21 | |
| 8 | New York City | 26 | 13 | 5 | 8 | 37 | 30 | +7 | 44 | WWWX | 12 | 9 | 0 | 3 | 21 | 11 | 14 | 4 | 5 | 5 | 16 | 19 | ||
| 9 | 1 | New York Red Bulls | 28 | 11 | 6 | 11 | 42 | 38 | +4 | 39 | LWWL | 14 | 10 | 2 | 2 | 34 | 19 | 14 | 1 | 4 | 9 | 8 | 19 | |
| 10 | 1 | Chicago Fire | 27 | 11 | 6 | 10 | 50 | 48 | +2 | 39 | LWXW | 13 | 4 | 5 | 4 | 17 | 18 | 14 | 7 | 1 | 6 | 33 | 30 | |
| 11 | New England Revolution | 27 | 8 | 7 | 12 | 35 | 38 | -3 | 31 | WLWL | 13 | 3 | 2 | 8 | 14 | 20 | 14 | 5 | 5 | 4 | 21 | 18 | ||
| 12 | Toronto FC | 27 | 5 | 9 | 13 | 27 | 34 | -7 | 24 | OXXL | 14 | 2 | 5 | 7 | 11 | 15 | 13 | 3 | 4 | 6 | 16 | 19 | ||
| 13 | 1 | CF Montréal | 28 | 5 | 8 | 15 | 28 | 50 | -22 | 23 | WXXW | 14 | 2 | 5 | 7 | 13 | 28 | 14 | 3 | 3 | 8 | 15 | 22 | |
| 14 | 1 | Atlanta United | 27 | 4 | 11 | 12 | 31 | 49 | -18 | 23 | OLXX | 14 | 4 | 6 | 4 | 23 | 22 | 13 | 0 | 5 | 8 | 8 | 27 | |
| 15 | D.C. United | 28 | 4 | 9 | 15 | 24 | 53 | -29 | 21 | XXLL | 14 | 2 | 6 | 6 | 12 | 23 | 14 | 2 | 3 | 9 | 12 | 30 | ||
| Group W | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | San Diego FC | 28 | 16 | 5 | 7 | 52 | 33 | +19 | 53 | OWWW | 15 | 7 | 5 | 3 | 24 | 13 | 13 | 9 | 0 | 4 | 28 | 20 | ||
| 2 | Minnesota United | 28 | 14 | 8 | 6 | 47 | 31 | +16 | 50 | WWLW | 14 | 7 | 3 | 4 | 25 | 16 | 14 | 7 | 5 | 2 | 22 | 15 | ||
| 3 | Vancouver Whitecaps | 27 | 14 | 7 | 6 | 47 | 31 | +16 | 49 | WXLW | 13 | 8 | 3 | 2 | 29 | 16 | 14 | 6 | 4 | 4 | 18 | 15 | ||
| 4 | Seattle Sounders | 27 | 12 | 8 | 7 | 48 | 38 | +10 | 44 | WLWX | 13 | 8 | 4 | 1 | 32 | 16 | 14 | 4 | 4 | 6 | 16 | 22 | ||
| 5 | Los Angeles | 25 | 11 | 8 | 6 | 44 | 31 | +13 | 41 | XWXL | 13 | 8 | 2 | 3 | 23 | 10 | 12 | 3 | 6 | 3 | 21 | 21 | ||
| 6 | Portland Timbers | 27 | 10 | 8 | 9 | 35 | 37 | -2 | 38 | OLLW | 14 | 6 | 5 | 3 | 21 | 19 | 13 | 4 | 3 | 6 | 14 | 18 | ||
| 7 | Colorado Rapids | 28 | 10 | 6 | 12 | 36 | 44 | -8 | 36 | LWWL | 14 | 7 | 2 | 5 | 20 | 17 | 14 | 3 | 4 | 7 | 16 | 27 | ||
| 8 | 1 | San Jose Earthquakes | 28 | 9 | 8 | 11 | 52 | 48 | +4 | 35 | WLWL | 14 | 4 | 6 | 4 | 32 | 24 | 14 | 5 | 2 | 7 | 20 | 24 | |
| 9 | 1 | Austin FC | 26 | 9 | 8 | 9 | 26 | 32 | -6 | 35 | LXXW | 13 | 4 | 7 | 2 | 11 | 11 | 13 | 5 | 1 | 7 | 15 | 21 | |
| 10 | Real Salt Lake | 27 | 9 | 4 | 14 | 28 | 36 | -8 | 31 | LLLW | 13 | 6 | 1 | 6 | 16 | 15 | 14 | 3 | 3 | 8 | 12 | 21 | ||
| 11 | FC Dallas | 27 | 7 | 9 | 11 | 39 | 47 | -8 | 30 | XXWL | 14 | 3 | 3 | 8 | 18 | 23 | 13 | 4 | 6 | 3 | 21 | 24 | ||
| 12 | Houston Dynamo | 27 | 7 | 8 | 12 | 34 | 44 | -10 | 29 | LXXX | 14 | 4 | 2 | 8 | 16 | 25 | 13 | 3 | 6 | 4 | 18 | 19 | ||
| 13 | Sporting Kansas City | 27 | 6 | 6 | 15 | 39 | 55 | -16 | 24 | LLLL | 13 | 3 | 4 | 6 | 20 | 26 | 14 | 3 | 2 | 9 | 19 | 29 | ||
| 14 | St. Louis CITY SC | 27 | 5 | 6 | 16 | 31 | 47 | -16 | 21 | LLWL | 13 | 4 | 4 | 5 | 18 | 19 | 14 | 1 | 2 | 11 | 13 | 28 | ||
| 15 | LA Galaxy | 27 | 4 | 7 | 16 | 32 | 55 | -23 | 19 | WLLX | 13 | 4 | 2 | 7 | 17 | 22 | 14 | 0 | 5 | 9 | 15 | 33 | ||
| 20 | +2 | Sam SURRIDGE (Nashville) |
| 19 | Lionel MESSI (Inter Miami) | |
| 16 | +1 | Tai BARIBO (Philadelphia Union) |
| EVANDER da Silva (FC Cincinnati) | ||
| 15 | Eric CHOUPO-MOTING (New York Red Bulls) | |
| Hugo CUYPERS (Chicago Fire) | ||
| 14 | Martín OJEDA (Orlando City) | |
| Denis BOUANGA (Los Angeles) | ||
| +1 | Alonso MARTÍNEZ (New York City) | |
| +2 | Hany MUKHTAR (Nashville) | |
| +1 | Brian WHITE (Vancouver Whitecaps) | |
| Dejan JOVELJIĆ (Sporting Kansas City) | ||
| 13 | Kévin DENKEY (FC Cincinnati) | |
| Anders DREYER (San Diego FC) | ||
| Diego ROSSI (Columbus Crew) | ||
| +3 | Danny MUSOVSKI (Seattle Sounders) | |
| Petar MUSA (FC Dallas) | ||
| 12 | Josef MARTÍNEZ (San Jose Earthquakes) | |
| +1 | Cristian ARANGO (San Jose Earthquakes) | |
| +1 | Prince-Osei OWUSU (CF Montréal) | |
| 11 | RAFAEL NAVARRO Leal (Colorado Rapids) | |
| Philip ZINCKERNAGEL (Chicago Fire) | ||
| Marco PAŠALIĆ (Orlando City) | ||
| +1 | Milan ILOSKI (Philadelphia Union) | |
| 10 | PEP BIEL Mas (Charlotte FC) | |
| Tani OLUWASEYI (Minnesota United) | ||
| Albert RUSNÁK (Seattle Sounders) |
| Saturday, 23 August 2025 | |||||
| D.C. United | 1-1 | Inter Miami | |||
| 13 | Hopkins | 64 | Rodríguez | ||
| FC Dallas | 1-1 | Los Angeles | |||
| 13 | Farrington | 6 | Son | ||
| Houston Dynamo | 1-2 | San Jose Earthquakes | |||
| 72 | Antônio Carlos | 28 | Arango | ||
| 64 | Judd | ||||
| Columbus Crew | 1-2 | New England Revolution | |||
| 71 | Gazdag | 25 | Campana | ||
| 39 | Ganago | ||||
| LA Galaxy | 3-0 | Colorado Rapids | |||
| 7 | Miller | ||||
| 55 | Wynder | ||||
| 75 | Gabriel Pec | ||||
| Vancouver Whitecaps | 3-2 | St. Louis CITY SC | |||
| 45+4(p) | White | 13 | Löwen | ||
| 79 | Rios | 73 | Klauss | ||
| 90+14(p) | Müller | ||||
| CF Montréal | 3-2 | Austin FC | |||
| 9 | Synchuk | 40 | Uzuni | ||
| 45+3 | Sealy | 77 | Wolff | ||
| 67(p) | Owusu | ||||
| Real Salt Lake | 1-3 | Minnesota United | |||
| 15 | Olatunji | 6(og) | Vera | ||
| 36 | Lod | ||||
| 51 | Pereyra | ||||
| Philadelphia Union | 4-0 | Chicago Fire | |||
| 34 | Baribo | ||||
| 64 | Wagner | ||||
| 73 | Jean-Jacques | ||||
| 80 | Iloski | ||||
| Nashville | 5-1 | Orlando City | |||
| 3 | Surridge | 76 | Muriel | ||
| 17 | Mukhtar | ||||
| 40 | Mukhtar | ||||
| 43 | Surridge | ||||
| 90+4 | Palacios | ||||
| FC Cincinnati | 0-1 | New York City | |||
| 55 | Martínez | ||||
| San Diego FC | 0-0 | Portland Timbers | |||
| Sunday, 24 August 2025 | |||||
| Seattle Sounders | 5-2 | Sporting Kansas City | |||
| 11 | Kossa-Rienzi | 36 | Toye | ||
| 45+1 | Musovski | 53(og) | Baker | ||
| 50 | Musovski | ||||
| 61 | Brunell | ||||
| 75(p) | Musovski | ||||
| Atlanta United | 0-0 | Toronto FC | |||
| Charlotte FC | 1-0 | New York Red Bulls | |||
| 30 | Vargas | ||||