| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | Apertura 2020 | 
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | Clausura 2021 | 
| Season archive | 
| Games | Goals | H | D | A | ||||
| 153 | 362 | 2.36 | 73 | 47.71% | 38 | 24.84% | 42 | 27.45% | 
| Clausura 2021 | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Cruz Azul | 17 | 13 | 2 | 2 | 26 | 11 | +15 | 41 | XWXW | 9 | 7 | 1 | 1 | 17 | 9 | 8 | 6 | 1 | 1 | 9 | 2 | ||
| 2 | América | 17 | 12 | 2 | 3 | 26 | 14 | +12 | 38 | WLXW | 8 | 7 | 1 | 0 | 14 | 5 | 9 | 5 | 1 | 3 | 12 | 9 | ||
| 3 | Puebla | 17 | 7 | 7 | 3 | 25 | 14 | +11 | 28 | OOWW | 9 | 3 | 4 | 2 | 10 | 5 | 8 | 4 | 3 | 1 | 15 | 9 | ||
| 4 | Monterrey | 17 | 8 | 4 | 5 | 22 | 13 | +9 | 28 | WLLL | 9 | 5 | 2 | 2 | 10 | 6 | 8 | 3 | 2 | 3 | 12 | 7 | ||
| 5 | Santos Laguna | 17 | 7 | 5 | 5 | 18 | 13 | +5 | 26 | OLWL | 9 | 6 | 2 | 1 | 15 | 7 | 8 | 1 | 3 | 4 | 3 | 6 | ||
| 6 | León | 17 | 8 | 2 | 7 | 25 | 23 | +2 | 26 | WLWW | 9 | 5 | 1 | 3 | 14 | 10 | 8 | 3 | 1 | 4 | 11 | 13 | ||
| 7 | Atlas | 17 | 7 | 4 | 6 | 20 | 15 | +5 | 25 | WLOL | 9 | 4 | 1 | 4 | 11 | 10 | 8 | 3 | 3 | 2 | 9 | 5 | ||
| 8 | 6 | Pachuca | 17 | 6 | 5 | 6 | 20 | 19 | +1 | 23 | WWWL | 8 | 3 | 2 | 3 | 7 | 8 | 9 | 3 | 3 | 3 | 13 | 11 | |
| 9 | Guadalajara | 17 | 5 | 8 | 4 | 21 | 21 | +0 | 23 | OWWW | 8 | 2 | 4 | 2 | 9 | 10 | 9 | 3 | 4 | 2 | 12 | 11 | ||
| 10 | Tigres | 17 | 6 | 5 | 6 | 19 | 20 | -1 | 23 | OWOW | 8 | 3 | 1 | 4 | 10 | 12 | 9 | 3 | 4 | 2 | 9 | 8 | ||
| 11 | 3 | Toluca | 17 | 6 | 4 | 7 | 26 | 24 | +2 | 22 | LWLL | 9 | 5 | 2 | 2 | 18 | 11 | 8 | 1 | 2 | 5 | 8 | 13 | |
| 12 | 1 | Querétaro | 17 | 6 | 3 | 8 | 19 | 25 | -6 | 21 | LWOW | 9 | 6 | 2 | 1 | 13 | 6 | 8 | 0 | 1 | 7 | 6 | 19 | |
| 13 | 1 | Mazatlán | 17 | 6 | 3 | 8 | 19 | 26 | -7 | 21 | LWOW | 9 | 4 | 3 | 2 | 12 | 10 | 8 | 2 | 0 | 6 | 7 | 16 | |
| 14 | 1 | Tijuana | 17 | 5 | 5 | 7 | 19 | 21 | -2 | 20 | XWLL | 8 | 4 | 1 | 3 | 11 | 9 | 9 | 1 | 4 | 4 | 8 | 12 | |
| 15 | 2 | UNAM | 17 | 4 | 6 | 7 | 10 | 12 | -2 | 18 | LOOW | 8 | 2 | 3 | 3 | 6 | 5 | 9 | 2 | 3 | 4 | 4 | 7 | |
| 16 | 1 | F.C. Juárez | 17 | 4 | 3 | 10 | 13 | 29 | -16 | 15 | WLLL | 8 | 3 | 2 | 3 | 8 | 12 | 9 | 1 | 1 | 7 | 5 | 17 | |
| 17 | 1 | Atlético San Luis | 17 | 3 | 3 | 11 | 20 | 33 | -13 | 12 | LLLL | 8 | 2 | 3 | 3 | 10 | 15 | 9 | 1 | 0 | 8 | 10 | 18 | |
| 18 | Necaxa | 17 | 2 | 5 | 10 | 14 | 29 | -15 | 11 | LLOL | 8 | 2 | 3 | 3 | 6 | 11 | 9 | 0 | 2 | 7 | 8 | 18 | ||
| Liguilla | ||||||
| Saturday, 15 May 2021 | ||||||
| qfl2 | Cruz Azul | 3-1 | Toluca | 4-3 | ||
| qfl2 | Puebla | 1-0 | Atlas | 1-1 | ||
| Sunday, 16 May 2021 | ||||||
| qfl2 | América | 4-2 | Pachuca | 5-5 | ||
| qfl2 | Monterrey | 1-1 | Santos Laguna | 2-3 | ||
| Wednesday, 19 May 2021 | ||||||
| sfl1 | Pachuca | 0-0 | Cruz Azul | |||
| Thursday, 20 May 2021 | ||||||
| sfl1 | Santos Laguna | 3-0 | Puebla | |||
| Saturday, 22 May 2021 | ||||||
| sfl2 | Cruz Azul | 1-0 | Pachuca | 1-0 | ||
| Sunday, 23 May 2021 | ||||||
| sfl2 | Puebla | 1-0 | Santos Laguna | 1-3 | ||
| Thursday, 27 May 2021 | ||||||
| fl1 | Santos Laguna | 0-1 | Cruz Azul | |||
| Sunday, 30 May 2021 | ||||||
| fl2 | Cruz Azul | 1-1 | Santos Laguna | 2-1 | ||
| 21 | Jonathan RODRÍGUEZ (Cruz Azul, 7p) | |
| 17 | Alexis CANELO (Toluca, 4p) | |
| 15 | +1 | Henry MARTIN (América, 1p) | 
| +2 | Ángel MENA (León, 8p) | |
| Santiago ORMEÑO (Puebla, 6p) | ||
| Dario LEZCANO (F.C. Juárez, 4p) | ||
| Rogelio FUNES (Monterrey, 4p) | ||
| 14 | Juan DINENNO (UNAM, 4p) | |
| André-Pierre GIGNAC (Tigres, 5p) | ||
| 13 | CAMILO da Silva (Mazatlán, 3p) | |
| Nicolás IBAÑEZ (Atlético San Luis, 6p) | ||
| 12 | Nicolás LÓPEZ (Tigres) | |
| 11 | José MACÍAS (Guadalajara, 2p) | |
| Victor DÁVILA (León, 1p) | ||
| 10 | Michael ESTRADA (Toluca, 1p) | |
| 9 | Carlos GONZÁLEZ (Tigres, 2p) | |
| Hugo SILVEIRA (Querétaro, 2p) | ||
| Ángel SEPÚLVEDA (Querétaro, 2p) | ||
| 8 | Germán BERTERAME (Atlético San Luis) | |
| Fidel MARTÍNEZ (Tijuana, 3p) | ||
| 7 | Francisco CÓRDOVA (América, 1p) | |
| Federico VIÑAS (América, 1p) | ||
| Jean MENESES (León) | ||
| Emanuel GIGLIOTTI (León) | ||
| Victor AGUILERA (América, 5p) | ||
| Fernando ARISTEGUIETA (Mazatlán) |