| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 244 | 779 | 3.19 | 129 | 52.87% | 53 | 21.72% | 62 | 25.41% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Atlanta United | 23 | 14 | 5 | 4 | 48 | 26 | +22 | 47 | WWXW | 12 | 7 | 3 | 2 | 31 | 14 | 11 | 7 | 2 | 2 | 17 | 12 | ||
| 2 | New York City | 21 | 13 | 4 | 4 | 42 | 24 | +18 | 43 | WWWW | 11 | 10 | 1 | 0 | 27 | 4 | 10 | 3 | 3 | 4 | 15 | 20 | ||
| 3 | New York Red Bulls | 21 | 13 | 2 | 6 | 42 | 22 | +20 | 41 | LWWW | 11 | 8 | 1 | 2 | 27 | 9 | 10 | 5 | 1 | 4 | 15 | 13 | ||
| 4 | Columbus Crew | 23 | 10 | 6 | 7 | 30 | 29 | +1 | 36 | WWLL | 12 | 7 | 3 | 2 | 24 | 17 | 11 | 3 | 3 | 5 | 6 | 12 | ||
| 5 | Montréal Impact | 23 | 9 | 1 | 13 | 29 | 39 | -10 | 28 | LXWL | 11 | 7 | 0 | 4 | 19 | 13 | 12 | 2 | 1 | 9 | 10 | 26 | ||
| 6 | New England Revolution | 21 | 7 | 7 | 7 | 33 | 32 | +1 | 28 | LLLO | 12 | 6 | 3 | 3 | 20 | 14 | 9 | 1 | 4 | 4 | 13 | 18 | ||
| 7 | Philadelphia Union | 21 | 8 | 3 | 10 | 29 | 34 | -5 | 27 | WLWL | 11 | 5 | 2 | 4 | 18 | 14 | 10 | 3 | 1 | 6 | 11 | 20 | ||
| 8 | Chicago Fire | 23 | 6 | 5 | 12 | 34 | 46 | -12 | 23 | LLLL | 12 | 4 | 2 | 6 | 20 | 22 | 11 | 2 | 3 | 6 | 14 | 24 | ||
| 9 | Orlando City | 21 | 7 | 1 | 13 | 29 | 47 | -18 | 22 | LLWL | 11 | 5 | 1 | 5 | 19 | 20 | 10 | 2 | 0 | 8 | 10 | 27 | ||
| 10 | Toronto FC | 21 | 6 | 4 | 11 | 35 | 39 | -4 | 22 | WWLX | 10 | 4 | 2 | 4 | 18 | 14 | 11 | 2 | 2 | 7 | 17 | 25 | ||
| 11 | D.C. United | 18 | 4 | 5 | 9 | 29 | 35 | -6 | 17 | WLLW | 5 | 3 | 1 | 1 | 8 | 5 | 13 | 1 | 4 | 8 | 21 | 30 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | FC Dallas | 21 | 12 | 6 | 3 | 35 | 25 | +10 | 42 | WXWL | 11 | 7 | 4 | 0 | 23 | 11 | 10 | 5 | 2 | 3 | 12 | 14 | ||
| 2 | Los Angeles | 21 | 10 | 6 | 5 | 44 | 35 | +9 | 36 | XLOW | 10 | 5 | 5 | 0 | 19 | 8 | 11 | 5 | 1 | 5 | 25 | 27 | ||
| 3 | 2 | Portland Timbers | 19 | 9 | 7 | 3 | 30 | 25 | +5 | 34 | WXOW | 9 | 6 | 3 | 0 | 16 | 8 | 10 | 3 | 4 | 3 | 14 | 17 | |
| 4 | 1 | Sporting Kansas City | 21 | 9 | 6 | 6 | 39 | 30 | +9 | 33 | LLXL | 11 | 6 | 3 | 2 | 24 | 14 | 10 | 3 | 3 | 4 | 15 | 16 | |
| 5 | 1 | LA Galaxy | 21 | 9 | 5 | 7 | 39 | 33 | +6 | 32 | XWWW | 10 | 5 | 1 | 4 | 20 | 16 | 11 | 4 | 4 | 3 | 19 | 17 | |
| 6 | Real Salt Lake | 22 | 9 | 4 | 9 | 31 | 39 | -8 | 31 | OXLW | 11 | 8 | 2 | 1 | 23 | 14 | 11 | 1 | 2 | 8 | 8 | 25 | ||
| 7 | 1 | Vancouver Whitecaps | 22 | 8 | 5 | 9 | 34 | 44 | -10 | 29 | WLLW | 11 | 5 | 4 | 2 | 23 | 17 | 11 | 3 | 1 | 7 | 11 | 27 | |
| 8 | 1 | Minnesota United | 22 | 9 | 1 | 12 | 35 | 44 | -9 | 28 | LWWW | 12 | 8 | 1 | 3 | 23 | 15 | 10 | 1 | 0 | 9 | 12 | 29 | |
| 9 | 2 | Houston Dynamo | 21 | 7 | 6 | 8 | 39 | 32 | +7 | 27 | LLXO | 11 | 6 | 2 | 3 | 25 | 14 | 10 | 1 | 4 | 5 | 14 | 18 | |
| 10 | Seattle Sounders | 20 | 6 | 5 | 9 | 19 | 23 | -4 | 23 | WWXO | 9 | 3 | 2 | 4 | 10 | 9 | 11 | 3 | 3 | 5 | 9 | 14 | ||
| 11 | Colorado Rapids | 21 | 4 | 5 | 12 | 25 | 36 | -11 | 17 | LXOL | 11 | 3 | 3 | 5 | 18 | 17 | 10 | 1 | 2 | 7 | 7 | 19 | ||
| 12 | San Jose Earthquakes | 21 | 2 | 7 | 12 | 29 | 40 | -11 | 13 | OLLL | 10 | 1 | 4 | 5 | 15 | 20 | 11 | 1 | 3 | 7 | 14 | 20 | ||
| 24 | +2 | Josef MARTÍNEZ (Atlanta United, 5p) |
| 14 | +1 | Bradley WRIGHT-PHILLIPS (New York Red Bulls) |
| 13 | Gyasi ZARDES (Columbus Crew, 3p) | |
| 12 | Zlatan IBRAHIMOVIĆ (LA Galaxy, 1p) | |
| 11 | +1 | Ignacio PIATTI (Montréal Impact, 2p) |
| +1 | Mauro MANOTAS (Houston Dynamo, 1p) | |
| 10 | Teal BUNBURY (New England Revolution, 1p) | |
| Nemanja NIKOLIĆ (Chicago Fire, 2p) | ||
| Danny HOESEN (San Jose Earthquakes) | ||
| 9 | +1 | Kei KAMARA (Vancouver Whitecaps, 3p) |
| Adama DIOMANDE (Los Angeles) | ||
| +1 | Ola KAMARA (LA Galaxy) | |
| +1 | Darwin QUINTERO (Minnesota United, 1p) | |
| Alberth ELIS (Houston Dynamo, 1p) | ||
| Aleksandar KATAI (Chicago Fire) | ||
| 8 | Yamil ASAD (D.C. United, 1p) | |
| Ismaël TAJOURI-SHRADI (New York City) | ||
| Dominic DWYER (Orlando City) | ||
| +1 | Carlos VELA (Los Angeles, 1p) | |
| +1 | Maximiliano MORALEZ (New York City, 1p) | |
| Cristian PENILLA (New England Revolution, 1p) | ||
| Darren MATTOCKS (D.C. United) | ||
| Miguel ALMIRON (Atlanta United, 4p) | ||
| David VILLA (New York City, 2p) | ||
| +1 | Jonathan OSORIO (Toronto FC) |
| Sunday, 22 July 2018 | |||||
| Minnesota United | 5-1 | Los Angeles | |||
| 25 | Schüller | 26 | Feilhaber | ||
| 45 | Ramirez | ||||
| 45 | Quintero | ||||
| 56 | Ibarra | ||||
| 58 | Ramirez | ||||
| Wednesday, 25 July 2018 | |||||
| D.C. United | 0-1 | New York Red Bulls | |||
| 2 | Wright-Phillips | ||||
| Houston Dynamo | 1-3 | Philadelphia Union | |||
| 10 | Manotas | 34 | Bedoya | ||
| 70 | Burke | ||||
| 90(p) | Picault | ||||
| San Jose Earthquakes | 0-1 | Seattle Sounders | |||
| 62 | Ruidíaz | ||||
| Thursday, 26 July 2018 | |||||
| Orlando City | 0-2 | New York City | |||
| 40 | Moralez | ||||
| 45 | Tinnerholm | ||||
| Los Angeles | 2-2 | LA Galaxy | |||
| 7 | Vela | 82 | Alessandrini | ||
| 20 | Nguyen | 86 | Kamara | ||
| Saturday, 28 July 2018 | |||||
| D.C. United | 2-1 | Colorado Rapids | |||
| 33 | Rooney | 82 | Acosta | ||
| 90(og) | Jackson | ||||
| New York Red Bulls | 2-3 | Columbus Crew | |||
| 50(og) | Mensah | 7 | Mensah | ||
| 69 | Royer | 24 | Mullins | ||
| 31(og) | Davis | ||||
| Sporting Kansas City | 2-3 | FC Dallas | |||
| 50 | Gerso | 23 | Barrios | ||
| 90 | Sallói | 62 | Barrios | ||
| 74 | Barrios | ||||
| Vancouver Whitecaps | 4-2 | Minnesota United | |||
| 35 | Reyna | 82 | Ibson | ||
| 56 | Davies | 87 | Danladi | ||
| 64 | Kamara | ||||
| 89 | Davies | ||||
| Montréal Impact | 1-2 | Atlanta United | |||
| 87 | Piatti | 31 | Martínez | ||
| 57 | Martínez | ||||
| Portland Timbers | 2-1 | Houston Dynamo | |||
| 7 | Blanco | 12 | Quioto | ||
| 80 | Adi | ||||
| Toronto FC | 3-0 | Chicago Fire | |||
| 52 | Altidore | ||||
| 72 | Osorio | ||||
| 89 | Giovinco | ||||
| San Jose Earthquakes | 0-0 | Real Salt Lake | |||