| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 298 | 946 | 3.17 | 156 | 52.35% | 66 | 22.15% | 76 | 25.50% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | New York Red Bulls | 27 | 17 | 4 | 6 | 50 | 26 | +24 | 55 | WWXX | 14 | 11 | 1 | 2 | 31 | 10 | 13 | 6 | 3 | 4 | 19 | 16 | |
| 2 | 1 | Atlanta United | 26 | 16 | 6 | 4 | 55 | 30 | +25 | 54 | WWXW | 14 | 8 | 4 | 2 | 36 | 17 | 12 | 8 | 2 | 2 | 19 | 13 | |
| 3 | New York City | 26 | 14 | 6 | 6 | 49 | 34 | +15 | 48 | XLWX | 13 | 10 | 3 | 0 | 30 | 7 | 13 | 4 | 3 | 6 | 19 | 27 | ||
| 4 | Columbus Crew | 26 | 11 | 7 | 8 | 33 | 33 | +0 | 40 | XLWW | 13 | 8 | 3 | 2 | 25 | 17 | 13 | 3 | 4 | 6 | 8 | 16 | ||
| 5 | Philadelphia Union | 26 | 12 | 3 | 11 | 37 | 39 | -2 | 39 | WWWW | 13 | 7 | 2 | 4 | 21 | 14 | 13 | 5 | 1 | 7 | 16 | 25 | ||
| 6 | Montréal Impact | 27 | 10 | 3 | 14 | 34 | 45 | -11 | 33 | LWXX | 13 | 8 | 1 | 4 | 22 | 15 | 14 | 2 | 2 | 10 | 12 | 30 | ||
| 7 | New England Revolution | 25 | 7 | 8 | 10 | 38 | 41 | -3 | 29 | LLLX | 13 | 6 | 3 | 4 | 22 | 17 | 12 | 1 | 5 | 6 | 16 | 24 | ||
| 8 | D.C. United | 24 | 7 | 6 | 11 | 39 | 42 | -3 | 27 | LLWW | 9 | 6 | 1 | 2 | 17 | 10 | 15 | 1 | 5 | 9 | 22 | 32 | ||
| 9 | Toronto FC | 26 | 7 | 6 | 13 | 43 | 48 | -5 | 27 | LWXL | 12 | 5 | 2 | 5 | 23 | 18 | 14 | 2 | 4 | 8 | 20 | 30 | ||
| 10 | Chicago Fire | 27 | 6 | 6 | 15 | 37 | 52 | -15 | 24 | XLLL | 14 | 4 | 3 | 7 | 21 | 24 | 13 | 2 | 3 | 8 | 16 | 28 | ||
| 11 | Orlando City | 25 | 7 | 2 | 16 | 38 | 59 | -21 | 23 | LLXL | 13 | 5 | 2 | 6 | 23 | 25 | 12 | 2 | 0 | 10 | 15 | 34 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | FC Dallas | 26 | 13 | 7 | 6 | 43 | 35 | +8 | 46 | LXWL | 13 | 8 | 4 | 1 | 26 | 14 | 13 | 5 | 3 | 5 | 17 | 21 | ||
| 2 | 1 | Sporting Kansas City | 25 | 13 | 6 | 6 | 47 | 30 | +17 | 45 | WWWW | 13 | 8 | 3 | 2 | 29 | 14 | 12 | 5 | 3 | 4 | 18 | 16 | |
| 3 | 1 | Los Angeles | 26 | 12 | 7 | 7 | 50 | 40 | +10 | 43 | XWWL | 13 | 7 | 5 | 1 | 23 | 10 | 13 | 5 | 2 | 6 | 27 | 30 | |
| 4 | Real Salt Lake | 27 | 12 | 5 | 10 | 42 | 44 | -2 | 41 | WWLX | 13 | 9 | 3 | 1 | 26 | 16 | 14 | 3 | 2 | 9 | 16 | 28 | ||
| 5 | 1 | Portland Timbers | 25 | 11 | 7 | 7 | 37 | 35 | +2 | 40 | WLLL | 13 | 8 | 3 | 2 | 22 | 11 | 12 | 3 | 4 | 5 | 15 | 24 | |
| 6 | 1 | Seattle Sounders | 25 | 11 | 5 | 9 | 32 | 26 | +6 | 38 | WWWW | 12 | 6 | 2 | 4 | 20 | 11 | 13 | 5 | 3 | 5 | 12 | 15 | |
| 7 | 2 | LA Galaxy | 27 | 10 | 8 | 9 | 49 | 48 | +1 | 38 | XLXX | 14 | 6 | 4 | 4 | 29 | 24 | 13 | 4 | 4 | 5 | 20 | 24 | |
| 8 | Vancouver Whitecaps | 26 | 10 | 7 | 9 | 43 | 51 | -8 | 37 | WXWX | 12 | 5 | 5 | 2 | 25 | 19 | 14 | 5 | 2 | 7 | 18 | 32 | ||
| 9 | Minnesota United | 26 | 9 | 2 | 15 | 38 | 52 | -14 | 29 | LLXL | 13 | 8 | 1 | 4 | 24 | 17 | 13 | 1 | 1 | 11 | 14 | 35 | ||
| 10 | Houston Dynamo | 26 | 7 | 7 | 12 | 41 | 38 | +3 | 28 | LXLL | 14 | 6 | 3 | 5 | 27 | 18 | 12 | 1 | 4 | 7 | 14 | 20 | ||
| 11 | Colorado Rapids | 26 | 6 | 6 | 14 | 31 | 48 | -17 | 24 | LLXW | 14 | 5 | 3 | 6 | 22 | 25 | 12 | 1 | 3 | 8 | 9 | 23 | ||
| 12 | San Jose Earthquakes | 26 | 4 | 8 | 14 | 40 | 50 | -10 | 20 | WLXL | 13 | 2 | 5 | 6 | 22 | 27 | 13 | 2 | 3 | 8 | 18 | 23 | ||
| 28 | Josef MARTÍNEZ (Atlanta United, 6p) | |
| 16 | Zlatan IBRAHIMOVIĆ (LA Galaxy, 1p) | |
| Bradley WRIGHT-PHILLIPS (New York Red Bulls) | ||
| 15 | Gyasi ZARDES (Columbus Crew, 3p) | |
| 12 | Ignacio PIATTI (Montréal Impact, 3p) | |
| Nemanja NIKOLIĆ (Chicago Fire, 2p) | ||
| 11 | +1 | Kei KAMARA (Vancouver Whitecaps, 3p) |
| Dominic DWYER (Orlando City) | ||
| Teal BUNBURY (New England Revolution, 1p) | ||
| Mauro MANOTAS (Houston Dynamo, 1p) | ||
| 10 | Ismaël TAJOURI-SHRADI (New York City) | |
| Darwin QUINTERO (Minnesota United, 1p) | ||
| David VILLA (New York City, 2p) | ||
| +2 | Sebastian GIOVINCO (Toronto FC, 1p) | |
| Daniel ROYER (New York Red Bulls, 1p) | ||
| Danny HOESEN (San Jose Earthquakes) | ||
| 9 | Yamil ASAD (D.C. United, 1p) | |
| Adama DIOMANDE (Los Angeles) | ||
| Ola KAMARA (LA Galaxy) | ||
| Carlos VELA (Los Angeles, 2p) | ||
| Cristian PENILLA (New England Revolution, 1p) | ||
| Darren MATTOCKS (D.C. United) | ||
| Miguel ALMIRON (Atlanta United, 4p) | ||
| Alberth ELIS (Houston Dynamo, 1p) | ||
| Diego VALERI (Portland Timbers, 4p) | ||
| Aleksandar KATAI (Chicago Fire) | ||
| +1 | Jonathan OSORIO (Toronto FC) | |
| +1 | Dominique BADJI (FC Dallas) | |
| Christian RAMIREZ (Los Angeles) |
| Saturday, 25 August 2018 | |||||
| Colorado Rapids | 0-6 | Real Salt Lake | |||
| 6 | Kreilach | ||||
| 33 | Savarino | ||||
| 58 | Savarino | ||||
| 69 | Plata | ||||
| 74 | Baird | ||||
| 86 | Rusnák | ||||
| Sporting Kansas City | 2-0 | Minnesota United | |||
| 47 | Croizet | ||||
| 62 | Rubio | ||||
| Toronto FC | 3-1 | Montréal Impact | |||
| 7 | Giovinco | 30 | Silva | ||
| 22 | Giovinco | ||||
| 29 | Osorio | ||||
| San Jose Earthquakes | 2-3 | Vancouver Whitecaps | |||
| 7 | Hyka | 59 | Reyna | ||
| 18(p) | Eriksson | 61 | Techera | ||
| 68 | Kamara | ||||
| Philadelphia Union | 1-0 | New England Revolution | |||
| 53 | Burke | ||||
| Sunday, 26 August 2018 | |||||
| New York Red Bulls | 1-0 | D.C. United | |||
| 56 | Romero | ||||
| Portland Timbers | 0-1 | Seattle Sounders | |||
| 76(og) | Cascante | ||||
| Wednesday, 29 August 2018 | |||||
| D.C. United | 0-2 | Philadelphia Union | |||
| 29 | Sapong | ||||
| 61 | Picault | ||||
| New York Red Bulls | 1-0 | Houston Dynamo | |||
| 55 | White | ||||
| Portland Timbers | 2-0 | Toronto FC | |||
| 64 | Chará | ||||
| 83 | Guzmán | ||||
| San Jose Earthquakes | 4-3 | FC Dallas | |||
| 15 | Qazaishvili | 8 | Urruti | ||
| 42 | Qazaishvili | 51 | Mosquera | ||
| 54 | Eriksson | 58 | Badji | ||
| 62 | Wondolowski | ||||