| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 308 | 989 | 3.21 | 163 | 52.92% | 68 | 22.08% | 77 | 25.00% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New York Red Bulls | 28 | 17 | 4 | 7 | 50 | 29 | +21 | 55 | LWWX | 14 | 11 | 1 | 2 | 31 | 10 | 14 | 6 | 3 | 5 | 19 | 19 | ||
| 2 | Atlanta United | 27 | 16 | 6 | 5 | 56 | 33 | +23 | 54 | LWWX | 14 | 8 | 4 | 2 | 36 | 17 | 13 | 8 | 2 | 3 | 20 | 16 | ||
| 3 | New York City | 27 | 14 | 6 | 7 | 50 | 36 | +14 | 48 | LXLW | 13 | 10 | 3 | 0 | 30 | 7 | 14 | 4 | 3 | 7 | 20 | 29 | ||
| 4 | Columbus Crew | 27 | 12 | 7 | 8 | 35 | 34 | +1 | 43 | WXLW | 14 | 9 | 3 | 2 | 27 | 18 | 13 | 3 | 4 | 6 | 8 | 16 | ||
| 5 | Philadelphia Union | 27 | 12 | 4 | 11 | 39 | 41 | -2 | 40 | XWWW | 13 | 7 | 2 | 4 | 21 | 14 | 14 | 5 | 2 | 7 | 18 | 27 | ||
| 6 | Montréal Impact | 28 | 11 | 3 | 14 | 37 | 45 | -8 | 36 | WLWX | 14 | 9 | 1 | 4 | 25 | 15 | 14 | 2 | 2 | 10 | 12 | 30 | ||
| 7 | 1 | D.C. United | 25 | 8 | 6 | 11 | 42 | 43 | -1 | 30 | WLLW | 10 | 7 | 1 | 2 | 20 | 11 | 15 | 1 | 5 | 9 | 22 | 32 | |
| 8 | 1 | New England Revolution | 26 | 7 | 9 | 10 | 39 | 42 | -3 | 30 | XLLL | 14 | 6 | 4 | 4 | 23 | 18 | 12 | 1 | 5 | 6 | 16 | 24 | |
| 9 | Toronto FC | 27 | 7 | 6 | 14 | 45 | 52 | -7 | 27 | LLWX | 13 | 5 | 2 | 6 | 25 | 22 | 14 | 2 | 4 | 8 | 20 | 30 | ||
| 10 | 1 | Orlando City | 26 | 7 | 3 | 16 | 40 | 61 | -21 | 24 | XLLX | 14 | 5 | 3 | 6 | 25 | 27 | 12 | 2 | 0 | 10 | 15 | 34 | |
| 11 | 1 | Chicago Fire | 27 | 6 | 6 | 15 | 37 | 52 | -15 | 24 | XLLL | 14 | 4 | 3 | 7 | 21 | 24 | 13 | 2 | 3 | 8 | 16 | 28 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | FC Dallas | 27 | 14 | 7 | 6 | 47 | 37 | +10 | 49 | WLXW | 14 | 9 | 4 | 1 | 30 | 16 | 13 | 5 | 3 | 5 | 17 | 21 | ||
| 2 | 1 | Los Angeles | 27 | 13 | 7 | 7 | 54 | 42 | +12 | 46 | WXWW | 13 | 7 | 5 | 1 | 23 | 10 | 14 | 6 | 2 | 6 | 31 | 32 | |
| 3 | 1 | Sporting Kansas City | 26 | 13 | 6 | 7 | 48 | 33 | +15 | 45 | LWWW | 13 | 8 | 3 | 2 | 29 | 14 | 13 | 5 | 3 | 5 | 19 | 19 | |
| 4 | Real Salt Lake | 28 | 13 | 5 | 10 | 48 | 46 | +2 | 44 | WWWL | 14 | 10 | 3 | 1 | 32 | 18 | 14 | 3 | 2 | 9 | 16 | 28 | ||
| 5 | 1 | Seattle Sounders | 26 | 12 | 5 | 9 | 35 | 27 | +8 | 41 | WWWW | 13 | 7 | 2 | 4 | 23 | 12 | 13 | 5 | 3 | 5 | 12 | 15 | |
| 6 | 1 | Portland Timbers | 26 | 11 | 8 | 7 | 38 | 36 | +2 | 41 | XWLL | 13 | 8 | 3 | 2 | 22 | 11 | 13 | 3 | 5 | 5 | 16 | 25 | |
| 7 | 1 | Vancouver Whitecaps | 27 | 11 | 7 | 9 | 45 | 52 | -7 | 40 | WWXW | 13 | 6 | 5 | 2 | 27 | 20 | 14 | 5 | 2 | 7 | 18 | 32 | |
| 8 | 1 | LA Galaxy | 28 | 10 | 8 | 10 | 51 | 54 | -3 | 38 | LXLX | 14 | 6 | 4 | 4 | 29 | 24 | 14 | 4 | 4 | 6 | 22 | 30 | |
| 9 | Minnesota United | 26 | 9 | 2 | 15 | 38 | 52 | -14 | 29 | LLXL | 13 | 8 | 1 | 4 | 24 | 17 | 13 | 1 | 1 | 11 | 14 | 35 | ||
| 10 | Houston Dynamo | 27 | 7 | 7 | 13 | 43 | 42 | +1 | 28 | LLXL | 14 | 6 | 3 | 5 | 27 | 18 | 13 | 1 | 4 | 8 | 16 | 24 | ||
| 11 | Colorado Rapids | 26 | 6 | 6 | 14 | 31 | 48 | -17 | 24 | LLXW | 14 | 5 | 3 | 6 | 22 | 25 | 12 | 1 | 3 | 8 | 9 | 23 | ||
| 12 | San Jose Earthquakes | 27 | 4 | 8 | 15 | 41 | 52 | -11 | 20 | LWLX | 13 | 2 | 5 | 6 | 22 | 27 | 14 | 2 | 3 | 9 | 19 | 25 | ||
| 28 | Josef MARTÍNEZ (Atlanta United, 6p) | |
| 16 | Zlatan IBRAHIMOVIĆ (LA Galaxy, 1p) | |
| Bradley WRIGHT-PHILLIPS (New York Red Bulls) | ||
| 15 | Gyasi ZARDES (Columbus Crew, 3p) | |
| 13 | +1 | Ignacio PIATTI (Montréal Impact, 3p) |
| 12 | +1 | Dominic DWYER (Orlando City) |
| Nemanja NIKOLIĆ (Chicago Fire, 2p) | ||
| +1 | Mauro MANOTAS (Houston Dynamo, 1p) | |
| 11 | Kei KAMARA (Vancouver Whitecaps, 3p) | |
| +1 | Ismaël TAJOURI-SHRADI (New York City) | |
| Teal BUNBURY (New England Revolution, 1p) | ||
| +2 | Carlos VELA (Los Angeles, 2p) | |
| 10 | +2 | Albert RUSNÁK (Real Salt Lake, 3p) |
| Darwin QUINTERO (Minnesota United, 1p) | ||
| David VILLA (New York City, 2p) | ||
| Sebastian GIOVINCO (Toronto FC, 1p) | ||
| +1 | Alberth ELIS (Houston Dynamo, 2p) | |
| Daniel ROYER (New York Red Bulls, 1p) | ||
| +3 | Damir KREILACH (Real Salt Lake) | |
| Danny HOESEN (San Jose Earthquakes) |
| Saturday, 1 September 2018 | |||||
| FC Dallas | 4-2 | Houston Dynamo | |||
| 10 | Barrios | 53 | Manotas | ||
| 48 | Mosquera | 72(p) | Elis | ||
| 51 | Mosquera | ||||
| 58(p) | Ziegler | ||||
| Columbus Crew | 2-1 | New York City | |||
| 61 | Afful | 53 | Tajouri-Shradi | ||
| 63 | Meram | ||||
| New England Revolution | 1-1 | Portland Timbers | |||
| 58 | Caldwell | 70 | Olum | ||
| Vancouver Whitecaps | 2-1 | San Jose Earthquakes | |||
| 22 | Davies | 90 | Qazaishvili | ||
| 78 | Mezquida | ||||
| Montréal Impact | 3-0 | New York Red Bulls | |||
| 30 | Fanni | ||||
| 38 | Sagna | ||||
| 90 | Piatti | ||||
| Seattle Sounders | 3-1 | Sporting Kansas City | |||
| 12 | Ruidíaz | 2 | Rubio | ||
| 52(og) | Zusi | ||||
| 56(p) | Lodeiro | ||||
| Real Salt Lake | 6-2 | LA Galaxy | |||
| 14 | Rusnák | 1 | Dos Santos | ||
| 45 | Kreilach | 63 | Alessandrini | ||
| 48 | Savarino | ||||
| 61 | Kreilach | ||||
| 68 | Rusnák | ||||
| 71 | Kreilach | ||||
| Toronto FC | 2-4 | Los Angeles | |||
| 74 | Altidore | 22 | Vela | ||
| 90 | Altidore | 47 | Rossi | ||
| 49 | Nguyen | ||||
| 90 | Vela | ||||
| Orlando City | 2-2 | Philadelphia Union | |||
| 9 | Dwyer | 32 | Burke | ||
| 90 | Sutter | 88 | Picault | ||
| Sunday, 2 September 2018 | |||||
| D.C. United | 3-1 | Atlanta United | |||
| 29 | Acosta | 39 | Larentowicz | ||
| 52(p) | Rooney | ||||
| 77 | Acosta | ||||