| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 335 | 1,075 | 3.20 | 175 | 52.24% | 76 | 22.69% | 84 | 25.07% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Atlanta United | 30 | 19 | 6 | 5 | 65 | 36 | +29 | 63 | WWWL | 15 | 9 | 4 | 2 | 38 | 17 | 15 | 10 | 2 | 3 | 27 | 19 | ||
| 2 | New York Red Bulls | 30 | 18 | 5 | 7 | 55 | 32 | +23 | 59 | WXLW | 15 | 12 | 1 | 2 | 33 | 10 | 15 | 6 | 4 | 5 | 22 | 22 | ||
| 3 | New York City | 30 | 14 | 8 | 8 | 52 | 39 | +13 | 50 | XXLL | 15 | 10 | 4 | 1 | 31 | 9 | 15 | 4 | 4 | 7 | 21 | 30 | ||
| 4 | Columbus Crew | 30 | 13 | 8 | 9 | 39 | 38 | +1 | 47 | WLOW | 15 | 10 | 3 | 2 | 29 | 19 | 15 | 3 | 5 | 7 | 10 | 19 | ||
| 5 | Philadelphia Union | 29 | 13 | 4 | 12 | 41 | 45 | -4 | 43 | WLXW | 14 | 7 | 2 | 5 | 22 | 18 | 15 | 6 | 2 | 7 | 19 | 27 | ||
| 6 | Montréal Impact | 30 | 12 | 4 | 14 | 42 | 47 | -5 | 40 | XWWL | 15 | 9 | 2 | 4 | 26 | 16 | 15 | 3 | 2 | 10 | 16 | 31 | ||
| 7 | D.C. United | 28 | 9 | 8 | 11 | 48 | 48 | +0 | 35 | XWXW | 12 | 8 | 2 | 2 | 25 | 15 | 16 | 1 | 6 | 9 | 23 | 33 | ||
| 8 | New England Revolution | 29 | 8 | 11 | 10 | 43 | 45 | -2 | 35 | XXWX | 15 | 6 | 5 | 4 | 25 | 20 | 14 | 2 | 6 | 6 | 18 | 25 | ||
| 9 | Toronto FC | 29 | 8 | 6 | 15 | 50 | 57 | -7 | 30 | LWLL | 14 | 6 | 2 | 6 | 30 | 25 | 15 | 2 | 4 | 9 | 20 | 32 | ||
| 10 | 1 | Chicago Fire | 29 | 7 | 7 | 15 | 43 | 54 | -11 | 28 | XWXL | 15 | 5 | 3 | 7 | 25 | 24 | 14 | 2 | 4 | 8 | 18 | 30 | |
| 11 | 1 | Orlando City | 29 | 7 | 4 | 18 | 40 | 66 | -26 | 25 | OLLX | 15 | 5 | 4 | 6 | 25 | 27 | 14 | 2 | 0 | 12 | 15 | 39 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Sporting Kansas City | 28 | 15 | 6 | 7 | 54 | 34 | +20 | 51 | WWLW | 14 | 9 | 3 | 2 | 30 | 14 | 14 | 6 | 3 | 5 | 24 | 20 | ||
| 2 | 1 | Los Angeles | 29 | 14 | 8 | 7 | 57 | 43 | +14 | 50 | WXWX | 15 | 8 | 6 | 1 | 26 | 11 | 14 | 6 | 2 | 6 | 31 | 32 | |
| 3 | 1 | FC Dallas | 28 | 14 | 8 | 6 | 47 | 37 | +10 | 50 | OWLX | 15 | 9 | 5 | 1 | 30 | 16 | 13 | 5 | 3 | 5 | 17 | 21 | |
| 4 | 2 | Portland Timbers | 30 | 13 | 8 | 9 | 46 | 45 | +1 | 47 | LWLW | 15 | 10 | 3 | 2 | 27 | 13 | 15 | 3 | 5 | 7 | 19 | 32 | |
| 5 | 1 | Real Salt Lake | 30 | 13 | 6 | 11 | 49 | 49 | +0 | 45 | LXWW | 15 | 10 | 4 | 1 | 33 | 19 | 15 | 3 | 2 | 10 | 16 | 30 | |
| 6 | 1 | Seattle Sounders | 28 | 13 | 5 | 10 | 37 | 29 | +8 | 44 | LWWW | 14 | 7 | 2 | 5 | 23 | 13 | 14 | 6 | 3 | 5 | 14 | 16 | |
| 7 | Vancouver Whitecaps | 28 | 11 | 7 | 10 | 46 | 54 | -8 | 40 | LWWX | 14 | 6 | 5 | 3 | 28 | 22 | 14 | 5 | 2 | 7 | 18 | 32 | ||
| 8 | LA Galaxy | 29 | 10 | 8 | 11 | 54 | 59 | -5 | 38 | LLXL | 14 | 6 | 4 | 4 | 29 | 24 | 15 | 4 | 4 | 7 | 25 | 35 | ||
| 9 | 1 | Minnesota United | 29 | 10 | 3 | 16 | 43 | 57 | -14 | 33 | WXLL | 14 | 9 | 1 | 4 | 27 | 19 | 15 | 1 | 2 | 12 | 16 | 38 | |
| 10 | 1 | Houston Dynamo | 29 | 8 | 8 | 13 | 47 | 43 | +4 | 32 | OWLL | 15 | 7 | 3 | 5 | 31 | 19 | 14 | 1 | 5 | 8 | 16 | 24 | |
| 11 | Colorado Rapids | 29 | 6 | 6 | 17 | 32 | 55 | -23 | 24 | LLLL | 15 | 5 | 3 | 7 | 22 | 28 | 14 | 1 | 3 | 10 | 10 | 27 | ||
| 12 | San Jose Earthquakes | 30 | 4 | 8 | 18 | 45 | 63 | -18 | 20 | LLLL | 15 | 2 | 5 | 8 | 26 | 36 | 15 | 2 | 3 | 10 | 19 | 27 | ||
| 30 | +2 | Josef MARTÍNEZ (Atlanta United, 7p) |
| 19 | +3 | Bradley WRIGHT-PHILLIPS (New York Red Bulls) |
| 17 | Zlatan IBRAHIMOVIĆ (LA Galaxy, 1p) | |
| 16 | +1 | Gyasi ZARDES (Columbus Crew, 3p) |
| 14 | +2 | Nemanja NIKOLIĆ (Chicago Fire, 2p) |
| Mauro MANOTAS (Houston Dynamo, 1p) | ||
| 13 | Ignacio PIATTI (Montréal Impact, 3p) | |
| 12 | Kei KAMARA (Vancouver Whitecaps, 3p) | |
| Dominic DWYER (Orlando City) | ||
| +1 | Miguel ALMIRON (Atlanta United, 4p) | |
| +1 | Danny HOESEN (San Jose Earthquakes) | |
| 11 | Ismaël TAJOURI-SHRADI (New York City) | |
| Teal BUNBURY (New England Revolution, 1p) | ||
| Carlos VELA (Los Angeles, 2p) | ||
| David VILLA (New York City, 2p) | ||
| Sebastian GIOVINCO (Toronto FC, 1p) | ||
| Alberth ELIS (Houston Dynamo, 2p) | ||
| Damir KREILACH (Real Salt Lake) | ||
| +2 | Aleksandar KATAI (Chicago Fire) | |
| 10 | +1 | Valeri QAZAISHVILI (San Jose Earthquakes) |
| Albert RUSNÁK (Real Salt Lake, 3p) | ||
| Ola KAMARA (LA Galaxy) | ||
| +1 | Cristian PENILLA (New England Revolution, 1p) | |
| Darren MATTOCKS (D.C. United) | ||
| Darwin QUINTERO (Minnesota United, 1p) | ||
| Diego VALERI (Portland Timbers, 4p) | ||
| Daniel ROYER (New York Red Bulls, 1p) | ||
| Jonathan OSORIO (Toronto FC) |
| Sunday, 16 September 2018 | |||||
| D.C. United | 3-3 | New York Red Bulls | |||
| 25 | Arriola | 41 | Wright-Phillips | ||
| 64 | Rooney | 76 | Wright-Phillips | ||
| 87 | Acosta | 90 | Wright-Phillips | ||
| Chicago Fire | 4-0 | Orlando City | |||
| 3 | Nikolić | ||||
| 28 | Katai | ||||
| 56 | De Leeuw | ||||
| 70 | Nikolić | ||||
| Wednesday, 19 September 2018 | |||||
| Portland Timbers | 3-2 | Columbus Crew | |||
| 18 | Guzmán | 7 | Hansen | ||
| 37 | Polo | 90 | Hansen | ||
| 48(og) | Abubakar | ||||
| Seattle Sounders | 0-1 | Philadelphia Union | |||
| 90 | Picault | ||||
| Toronto FC | 1-3 | Tigres | |||
| 87(p) | Janson | 36 | Dueñas | ||
| 64 | Dueñas | ||||
| 68(og) | Zavaleta | ||||
| San Jose Earthquakes | 3-4 | Atlanta United | |||
| 13 | Lima | 45 | Villalba | ||
| 43 | Hoesen | 70(p) | Martínez | ||
| 58 | Qazaishvili | 73 | Almiron | ||
| 90 | Martínez | ||||
| Saturday, 22 September 2018 | |||||
| New York Red Bulls | 2-0 | Toronto FC | |||
| 70 | Romero | ||||
| 90 | Etienne | ||||
| Columbus Crew | 2-1 | Colorado Rapids | |||
| 17 | Zardes | 26 | Gashi | ||
| 57 | Higuaín | ||||
| New England Revolution | 2-2 | Chicago Fire | |||
| 62 | Caldwell | 19 | Katai | ||
| 70 | Penilla | 67(og) | Mancienne | ||
| Montréal Impact | 1-1 | New York City | |||
| 27 | Azira | 17(og) | Camacho | ||
| Orlando City | 0-0 | Houston Dynamo | |||
| Minnesota United | 3-2 | Portland Timbers | |||
| 18 | Ibarra | 55 | Powell | ||
| 36 | Ibarra | 79 | Blanco | ||
| 43 | Boxall | ||||
| Los Angeles | 2-0 | San Jose Earthquakes | |||
| 41 | Zimmerman | ||||
| 68 | Zimmerman | ||||
| Atlanta United | 2-0 | Real Salt Lake | |||
| 37 | Gressel | ||||
| 61 | Villalba | ||||