| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 348 | 1,114 | 3.20 | 185 | 53.16% | 78 | 22.41% | 85 | 24.43% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Atlanta United | 30 | 19 | 6 | 5 | 65 | 36 | +29 | 63 | WWWL | 15 | 9 | 4 | 2 | 38 | 17 | 15 | 10 | 2 | 3 | 27 | 19 | ||
| 2 | New York Red Bulls | 30 | 18 | 5 | 7 | 55 | 32 | +23 | 59 | WXLW | 15 | 12 | 1 | 2 | 33 | 10 | 15 | 6 | 4 | 5 | 22 | 22 | ||
| 3 | New York City | 32 | 15 | 8 | 9 | 55 | 41 | +14 | 53 | LWXX | 16 | 11 | 4 | 1 | 33 | 9 | 16 | 4 | 4 | 8 | 22 | 32 | ||
| 4 | Columbus Crew | 31 | 13 | 9 | 9 | 39 | 38 | +1 | 48 | OWLO | 16 | 10 | 4 | 2 | 29 | 19 | 15 | 3 | 5 | 7 | 10 | 19 | ||
| 5 | Philadelphia Union | 31 | 14 | 5 | 12 | 43 | 45 | -2 | 47 | OWWL | 15 | 8 | 2 | 5 | 24 | 18 | 16 | 6 | 3 | 7 | 19 | 27 | ||
| 6 | Montréal Impact | 31 | 12 | 4 | 15 | 42 | 52 | -10 | 40 | LXWW | 15 | 9 | 2 | 4 | 26 | 16 | 16 | 3 | 2 | 11 | 16 | 36 | ||
| 7 | D.C. United | 29 | 10 | 8 | 11 | 53 | 48 | +5 | 38 | WXWX | 13 | 9 | 2 | 2 | 30 | 15 | 16 | 1 | 6 | 9 | 23 | 33 | ||
| 8 | New England Revolution | 30 | 8 | 11 | 11 | 44 | 49 | -5 | 35 | LXXW | 15 | 6 | 5 | 4 | 25 | 20 | 15 | 2 | 6 | 7 | 19 | 29 | ||
| 9 | Toronto FC | 30 | 9 | 6 | 15 | 54 | 58 | -4 | 33 | WLWL | 15 | 7 | 2 | 6 | 34 | 26 | 15 | 2 | 4 | 9 | 20 | 32 | ||
| 10 | Chicago Fire | 31 | 8 | 7 | 16 | 46 | 57 | -11 | 31 | WLXW | 16 | 6 | 3 | 7 | 28 | 25 | 15 | 2 | 4 | 9 | 18 | 32 | ||
| 11 | Orlando City | 29 | 7 | 4 | 18 | 40 | 66 | -26 | 25 | OLLX | 15 | 5 | 4 | 6 | 25 | 27 | 14 | 2 | 0 | 12 | 15 | 39 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 2 | FC Dallas | 30 | 15 | 9 | 6 | 49 | 38 | +11 | 54 | OWOW | 15 | 9 | 5 | 1 | 30 | 16 | 15 | 6 | 4 | 5 | 19 | 22 | |
| 2 | 1 | Sporting Kansas City | 29 | 15 | 6 | 8 | 54 | 36 | +18 | 51 | LWWL | 14 | 9 | 3 | 2 | 30 | 14 | 15 | 6 | 3 | 6 | 24 | 22 | |
| 3 | 1 | Los Angeles | 30 | 14 | 8 | 8 | 58 | 46 | +12 | 50 | LWXW | 15 | 8 | 6 | 1 | 26 | 11 | 15 | 6 | 2 | 7 | 32 | 35 | |
| 4 | Portland Timbers | 31 | 13 | 9 | 9 | 46 | 45 | +1 | 48 | OLWL | 16 | 10 | 4 | 2 | 27 | 13 | 15 | 3 | 5 | 7 | 19 | 32 | ||
| 5 | 1 | Seattle Sounders | 30 | 14 | 5 | 11 | 41 | 32 | +9 | 47 | WLLW | 15 | 8 | 2 | 5 | 27 | 13 | 15 | 6 | 3 | 6 | 14 | 19 | |
| 6 | 1 | Real Salt Lake | 30 | 13 | 6 | 11 | 49 | 49 | +0 | 45 | LXWW | 15 | 10 | 4 | 1 | 33 | 19 | 15 | 3 | 2 | 10 | 16 | 30 | |
| 7 | 1 | LA Galaxy | 31 | 12 | 8 | 11 | 60 | 59 | +1 | 44 | WWLL | 16 | 8 | 4 | 4 | 35 | 24 | 15 | 4 | 4 | 7 | 25 | 35 | |
| 8 | 1 | Vancouver Whitecaps | 30 | 11 | 7 | 12 | 47 | 59 | -12 | 40 | LLLW | 15 | 6 | 5 | 4 | 29 | 24 | 15 | 5 | 2 | 8 | 18 | 35 | |
| 9 | Minnesota United | 30 | 11 | 3 | 16 | 45 | 58 | -13 | 36 | WWXL | 15 | 10 | 1 | 4 | 29 | 20 | 15 | 1 | 2 | 12 | 16 | 38 | ||
| 10 | Houston Dynamo | 30 | 9 | 8 | 13 | 50 | 45 | +5 | 35 | WOWL | 16 | 8 | 3 | 5 | 34 | 21 | 14 | 1 | 5 | 8 | 16 | 24 | ||
| 11 | Colorado Rapids | 30 | 6 | 6 | 18 | 32 | 59 | -27 | 24 | LLLL | 15 | 5 | 3 | 7 | 22 | 28 | 15 | 1 | 3 | 11 | 10 | 31 | ||
| 12 | San Jose Earthquakes | 31 | 4 | 8 | 19 | 47 | 66 | -19 | 20 | LLLL | 15 | 2 | 5 | 8 | 26 | 36 | 16 | 2 | 3 | 11 | 21 | 30 | ||
| 30 | Josef MARTÍNEZ (Atlanta United, 7p) | |
| 20 | +3 | Zlatan IBRAHIMOVIĆ (LA Galaxy, 3p) |
| 19 | Bradley WRIGHT-PHILLIPS (New York Red Bulls) | |
| 16 | Gyasi ZARDES (Columbus Crew, 3p) | |
| 15 | +1 | Nemanja NIKOLIĆ (Chicago Fire, 3p) |
| +1 | Mauro MANOTAS (Houston Dynamo, 1p) | |
| 13 | +1 | Kei KAMARA (Vancouver Whitecaps, 3p) |
| Ignacio PIATTI (Montréal Impact, 3p) | ||
| 12 | Dominic DWYER (Orlando City) | |
| Miguel ALMIRON (Atlanta United, 4p) | ||
| +1 | David VILLA (New York City, 2p) | |
| +1 | Sebastian GIOVINCO (Toronto FC, 1p) | |
| +1 | Aleksandar KATAI (Chicago Fire) | |
| Danny HOESEN (San Jose Earthquakes) | ||
| 11 | Ismaël TAJOURI-SHRADI (New York City) | |
| Teal BUNBURY (New England Revolution, 1p) | ||
| +1 | Ola KAMARA (LA Galaxy) | |
| Carlos VELA (Los Angeles, 2p) | ||
| +1 | Cristian PENILLA (New England Revolution, 1p) | |
| Alberth ELIS (Houston Dynamo, 2p) | ||
| Damir KREILACH (Real Salt Lake) |
| Sunday, 23 September 2018 | |||||
| LA Galaxy | 3-0 | Seattle Sounders | |||
| 9(p) | Ibrahimović | ||||
| 40 | Kamara | ||||
| 52 | Boateng | ||||
| Vancouver Whitecaps | 1-2 | FC Dallas | |||
| 66 | Kamara | 42 | Mosquera | ||
| 87 | Hedges | ||||
| Philadelphia Union | 2-0 | Sporting Kansas City | |||
| 71 | Simpson | ||||
| 89 | Simpson | ||||
| Wednesday, 26 September 2018 | |||||
| New York City | 2-0 | Chicago Fire | |||
| 47 | Ring | ||||
| 51 | Villa | ||||
| Saturday, 29 September 2018 | |||||
| D.C. United | 5-0 | Montréal Impact | |||
| 17 | Acosta | ||||
| 48 | Rooney | ||||
| 61 | Arriola | ||||
| 78 | Arriola | ||||
| 82 | Rooney | ||||
| Houston Dynamo | 3-2 | San Jose Earthquakes | |||
| 56 | Manotas | 37(p) | Wondolowski | ||
| 68 | Martínez | 45(og) | Fuenmayor | ||
| 87 | Quioto | ||||
| Columbus Crew | 0-0 | Philadelphia Union | |||
| LA Galaxy | 3-0 | Vancouver Whitecaps | |||
| 4(p) | Ibrahimović | ||||
| 58 | Ibrahimović | ||||
| 77(p) | Alessandrini | ||||
| Chicago Fire | 3-1 | Los Angeles | |||
| 20 | Mihailovic | 73 | Rossi | ||
| 29(p) | Nikolić | ||||
| 66 | Katai | ||||
| Portland Timbers | 0-0 | FC Dallas | |||
| Seattle Sounders | 4-0 | Colorado Rapids | |||
| 22 | Ruidíaz | ||||
| 52(p) | Lodeiro | ||||
| 73 | Ruidíaz | ||||
| 80 | Víctor | ||||
| Toronto FC | 4-1 | New England Revolution | |||
| 36 | Giovinco | 10 | Penilla | ||
| 53 | Janson | ||||
| 58(p) | Víctor Vázquez | ||||
| 81 | Delgado | ||||
| Minnesota United | 2-1 | New York City | |||
| 20 | Rodríguez | 90 | Wallace | ||
| 36 | Rodríguez | ||||