| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 287 | 914 | 3.18 | 149 | 51.92% | 66 | 23.00% | 72 | 25.09% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Atlanta United | 26 | 16 | 6 | 4 | 55 | 30 | +25 | 54 | WWXW | 14 | 8 | 4 | 2 | 36 | 17 | 12 | 8 | 2 | 2 | 19 | 13 | |
| 2 | 1 | New York Red Bulls | 25 | 15 | 4 | 6 | 48 | 26 | +22 | 49 | XXWW | 12 | 9 | 1 | 2 | 29 | 10 | 13 | 6 | 3 | 4 | 19 | 16 | |
| 3 | New York City | 26 | 14 | 6 | 6 | 49 | 34 | +15 | 48 | XLWX | 13 | 10 | 3 | 0 | 30 | 7 | 13 | 4 | 3 | 6 | 19 | 27 | ||
| 4 | Columbus Crew | 26 | 11 | 7 | 8 | 33 | 33 | +0 | 40 | XLWW | 13 | 8 | 3 | 2 | 25 | 17 | 13 | 3 | 4 | 6 | 8 | 16 | ||
| 5 | Philadelphia Union | 24 | 10 | 3 | 11 | 34 | 39 | -5 | 33 | WWLW | 12 | 6 | 2 | 4 | 20 | 14 | 12 | 4 | 1 | 7 | 14 | 25 | ||
| 6 | Montréal Impact | 26 | 10 | 3 | 13 | 33 | 42 | -9 | 33 | WXXL | 13 | 8 | 1 | 4 | 22 | 15 | 13 | 2 | 2 | 9 | 11 | 27 | ||
| 7 | New England Revolution | 24 | 7 | 8 | 9 | 38 | 40 | -2 | 29 | LLXL | 13 | 6 | 3 | 4 | 22 | 17 | 11 | 1 | 5 | 5 | 16 | 23 | ||
| 8 | D.C. United | 22 | 7 | 6 | 9 | 39 | 39 | +0 | 27 | WWWX | 8 | 6 | 1 | 1 | 17 | 8 | 14 | 1 | 5 | 8 | 22 | 31 | ||
| 9 | Toronto FC | 24 | 6 | 6 | 12 | 40 | 45 | -5 | 24 | XLXW | 11 | 4 | 2 | 5 | 20 | 17 | 13 | 2 | 4 | 7 | 20 | 28 | ||
| 10 | 1 | Chicago Fire | 27 | 6 | 6 | 15 | 37 | 52 | -15 | 24 | XLLL | 14 | 4 | 3 | 7 | 21 | 24 | 13 | 2 | 3 | 8 | 16 | 28 | |
| 11 | 1 | Orlando City | 25 | 7 | 2 | 16 | 38 | 59 | -21 | 23 | LLXL | 13 | 5 | 2 | 6 | 23 | 25 | 12 | 2 | 0 | 10 | 15 | 34 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | FC Dallas | 25 | 13 | 7 | 5 | 40 | 31 | +9 | 46 | XWLL | 13 | 8 | 4 | 1 | 26 | 14 | 12 | 5 | 3 | 4 | 14 | 17 | ||
| 2 | 1 | Los Angeles | 26 | 12 | 7 | 7 | 50 | 40 | +10 | 43 | XWWL | 13 | 7 | 5 | 1 | 23 | 10 | 13 | 5 | 2 | 6 | 27 | 30 | |
| 3 | 1 | Sporting Kansas City | 24 | 12 | 6 | 6 | 45 | 30 | +15 | 42 | WWWL | 12 | 7 | 3 | 2 | 27 | 14 | 12 | 5 | 3 | 4 | 18 | 16 | |
| 4 | Real Salt Lake | 26 | 11 | 5 | 10 | 36 | 44 | -8 | 38 | WLXW | 13 | 9 | 3 | 1 | 26 | 16 | 13 | 2 | 2 | 9 | 10 | 28 | ||
| 5 | LA Galaxy | 27 | 10 | 8 | 9 | 49 | 48 | +1 | 38 | XLXX | 14 | 6 | 4 | 4 | 29 | 24 | 13 | 4 | 4 | 5 | 20 | 24 | ||
| 6 | Portland Timbers | 23 | 10 | 7 | 6 | 35 | 34 | +1 | 37 | LLLW | 11 | 7 | 3 | 1 | 20 | 10 | 12 | 3 | 4 | 5 | 15 | 24 | ||
| 7 | Seattle Sounders | 24 | 10 | 5 | 9 | 31 | 26 | +5 | 35 | WWWW | 12 | 6 | 2 | 4 | 20 | 11 | 12 | 4 | 3 | 5 | 11 | 15 | ||
| 8 | Vancouver Whitecaps | 25 | 9 | 7 | 9 | 40 | 49 | -9 | 34 | XWXW | 12 | 5 | 5 | 2 | 25 | 19 | 13 | 4 | 2 | 7 | 15 | 30 | ||
| 9 | Minnesota United | 25 | 9 | 2 | 14 | 38 | 50 | -12 | 29 | LXLL | 13 | 8 | 1 | 4 | 24 | 17 | 12 | 1 | 1 | 10 | 14 | 33 | ||
| 10 | Houston Dynamo | 25 | 7 | 7 | 11 | 41 | 37 | +4 | 28 | XLLL | 14 | 6 | 3 | 5 | 27 | 18 | 11 | 1 | 4 | 6 | 14 | 19 | ||
| 11 | Colorado Rapids | 25 | 6 | 6 | 13 | 31 | 42 | -11 | 24 | LXWW | 13 | 5 | 3 | 5 | 22 | 19 | 12 | 1 | 3 | 8 | 9 | 23 | ||
| 12 | San Jose Earthquakes | 24 | 3 | 8 | 13 | 34 | 44 | -10 | 17 | XLWO | 11 | 1 | 5 | 5 | 16 | 21 | 13 | 2 | 3 | 8 | 18 | 23 | ||
| 28 | +2 | Josef MARTÍNEZ (Atlanta United, 6p) |
| 16 | +1 | Zlatan IBRAHIMOVIĆ (LA Galaxy, 1p) |
| +1 | Bradley WRIGHT-PHILLIPS (New York Red Bulls) | |
| 15 | +1 | Gyasi ZARDES (Columbus Crew, 3p) |
| 12 | Ignacio PIATTI (Montréal Impact, 3p) | |
| +1 | Nemanja NIKOLIĆ (Chicago Fire, 2p) | |
| 11 | Dominic DWYER (Orlando City) | |
| Teal BUNBURY (New England Revolution, 1p) | ||
| Mauro MANOTAS (Houston Dynamo, 1p) | ||
| 10 | Kei KAMARA (Vancouver Whitecaps, 3p) | |
| Ismaël TAJOURI-SHRADI (New York City) | ||
| Darwin QUINTERO (Minnesota United, 1p) | ||
| +1 | David VILLA (New York City, 2p) | |
| Daniel ROYER (New York Red Bulls, 1p) | ||
| Danny HOESEN (San Jose Earthquakes) | ||
| 9 | Yamil ASAD (D.C. United, 1p) | |
| Adama DIOMANDE (Los Angeles) | ||
| Ola KAMARA (LA Galaxy) | ||
| +1 | Carlos VELA (Los Angeles, 2p) | |
| Cristian PENILLA (New England Revolution, 1p) | ||
| Darren MATTOCKS (D.C. United) | ||
| +1 | Miguel ALMIRON (Atlanta United, 4p) | |
| Alberth ELIS (Houston Dynamo, 1p) | ||
| Diego VALERI (Portland Timbers, 4p) | ||
| Aleksandar KATAI (Chicago Fire) | ||
| Christian RAMIREZ (Los Angeles) |
| Sunday, 19 August 2018 | |||||
| D.C. United | 2-0 | New England Revolution | |||
| 13 | Acosta | ||||
| 89 | Stieber | ||||
| Los Angeles | 2-0 | Colorado Rapids | |||
| 49 | Nguyen | ||||
| 80 | Rossi | ||||
| Atlanta United | 3-1 | Columbus Crew | |||
| 31 | Martínez | 50 | Zardes | ||
| 76 | Villalba | ||||
| 82 | Almiron | ||||
| Wednesday, 22 August 2018 | |||||
| New York City | 1-1 | New York Red Bulls | |||
| 52 | Villa | 37 | Wright-Phillips | ||
| Thursday, 23 August 2018 | |||||
| Houston Dynamo | 1-1 | FC Dallas | |||
| 88 | Peña | 83 | Barrios | ||
| Chicago Fire | 1-1 | Columbus Crew | |||
| 67 | Nikolić | 87 | Hansen | ||
| Friday, 24 August 2018 | |||||
| LA Galaxy | 1-1 | Los Angeles | |||
| 15 | Ibrahimović | 51(p) | Vela | ||
| Orlando City | 1-2 | Atlanta United | |||
| 39 | Sutter | 21 | González Pirez | ||
| 74 | Martínez | ||||